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Items: 1 to 20 of 192

1.

Structural Analysis of the Ash2L/Dpy-30 Complex Reveals a Heterogeneity in H3K4 Methylation.

Haddad JF, Yang Y, Takahashi YH, Joshi M, Chaudhary N, Woodfin AR, Benyoucef A, Yeung S, Brunzelle JS, Skiniotis G, Brand M, Shilatifard A, Couture JF.

Structure. 2018 Sep 27. pii: S0969-2126(18)30292-2. doi: 10.1016/j.str.2018.08.004. [Epub ahead of print]

PMID:
30270175
2.

Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis.

Hong SH, Fang S, Lu BC, Nofsinger R, Kawakami Y, Castro GL, Yin Y, Lin C, Yu RT, Downes M, Izpisúa Belmonte JC, Shilatifard A, Evans RM.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10381-10386. doi: 10.1073/pnas.1809480115. Epub 2018 Sep 25.

3.

Promoter bivalency favors an open chromatin architecture in embryonic stem cells.

Mas G, Blanco E, Ballaré C, Sansó M, Spill YG, Hu D, Aoi Y, Le Dily F, Shilatifard A, Marti-Renom MA, Di Croce L.

Nat Genet. 2018 Oct;50(10):1452-1462. doi: 10.1038/s41588-018-0218-5. Epub 2018 Sep 17.

PMID:
30224650
4.

USP7 cooperates with NOTCH1 to drive the oncogenic transcriptional program in T cell leukemia.

Jin Q, Martinez CA, Arcipowski KM, Zhu Y, Gutiérrez-Díaz BT, Wang KK, Johnson MR, Volk A, Wang F, Wu J, Grove C, Wang H, Sokirniy I, Thomas PM, Goo YA, Abshiru NA, Hijiya N, Peirs S, Vandamme N, Berx G, Goossens S, Marshall SA, Rendleman EJ, Takahashi YH, Wang L, Rawat R, Bartom ET, Collings CK, Van Vlierberghe P, Bourquin JP, Bornhauser B, Serafin V, Bresolin S, Paganin M, Accordi B, Basso G, Kelleher NL, Weinstock J, Suresh K, Crispino JD, Shilatifard A, Strikoudis A, Mantis C, Kandela I, Kelly S, Ueberheide B, Ntziachristos P.

Clin Cancer Res. 2018 Sep 17. pii: clincanres.1740.2018. doi: 10.1158/1078-0432.CCR-18-1740. [Epub ahead of print]

PMID:
30224337
5.

Structure and Conformational Dynamics of a COMPASS Histone H3K4 Methyltransferase Complex.

Qu Q, Takahashi YH, Yang Y, Hu H, Zhang Y, Brunzelle JS, Couture JF, Shilatifard A, Skiniotis G.

Cell. 2018 Aug 23;174(5):1117-1126.e12. doi: 10.1016/j.cell.2018.07.020. Epub 2018 Aug 9.

PMID:
30100186
6.

Impactful science as the guiding principle.

Shilatifard A.

Sci Adv. 2018 Jul 4;4(7):eaau1696. doi: 10.1126/sciadv.aau1696. eCollection 2018 Jul. No abstract available.

7.

Epigenetic ConFUSION: SS18-SSX Fusion Rewires BAF Complex to Activate Bivalent Genes in Synovial Sarcoma.

Morgan MA, Shilatifard A.

Cancer Cell. 2018 Jun 11;33(6):951-953. doi: 10.1016/j.ccell.2018.05.011.

PMID:
29894696
8.

MLL4 Is Required to Maintain Broad H3K4me3 Peaks and Super-Enhancers at Tumor Suppressor Genes.

Dhar SS, Zhao D, Lin T, Gu B, Pal K, Wu SJ, Alam H, Lv J, Yun K, Gopalakrishnan V, Flores ER, Northcott PA, Rajaram V, Li W, Shilatifard A, Sillitoe RV, Chen K, Lee MG.

Mol Cell. 2018 Jun 7;70(5):825-841.e6. doi: 10.1016/j.molcel.2018.04.028. Epub 2018 May 31.

PMID:
29861161
9.

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy.

Wang L, Zhao Z, Ozark PA, Fantini D, Marshall SA, Rendleman EJ, Cozzolino KA, Louis N, He X, Morgan MA, Takahashi YH, Collings CK, Smith ER, Ntziachristos P, Savas JN, Zou L, Hashizume R, Meeks JJ, Shilatifard A.

Nat Med. 2018 Jun;24(6):758-769. doi: 10.1038/s41591-018-0034-6. Epub 2018 May 21.

PMID:
29785026
10.

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis.

Frankowski KJ, Wang C, Patnaik S, Schoenen FJ, Southall N, Li D, Teper Y, Sun W, Kandela I, Hu D, Dextras C, Knotts Z, Bian Y, Norton J, Titus S, Lewandowska MA, Wen Y, Farley KI, Griner LM, Sultan J, Meng Z, Zhou M, Vilimas T, Powers AS, Kozlov S, Nagashima K, Quadri HS, Fang M, Long C, Khanolkar O, Chen W, Kang J, Huang H, Chow E, Goldberg E, Feldman C, Xi R, Kim HR, Sahagian G, Baserga SJ, Mazar A, Ferrer M, Zheng W, Shilatifard A, Aubé J, Rudloff U, Marugan JJ, Huang S.

Sci Transl Med. 2018 May 16;10(441). pii: eaap8307. doi: 10.1126/scitranslmed.aap8307.

11.

Enhancer Logic and Mechanics in Development and Disease.

Rickels R, Shilatifard A.

Trends Cell Biol. 2018 Aug;28(8):608-630. doi: 10.1016/j.tcb.2018.04.003. Epub 2018 May 11. Review.

PMID:
29759817
12.

Born to run: control of transcription elongation by RNA polymerase II.

Chen FX, Smith ER, Shilatifard A.

Nat Rev Mol Cell Biol. 2018 Jul;19(7):464-478. doi: 10.1038/s41580-018-0010-5. Review.

PMID:
29740129
13.

An Mll4/COMPASS-Lsd1 epigenetic axis governs enhancer function and pluripotency transition in embryonic stem cells.

Cao K, Collings CK, Morgan MA, Marshall SA, Rendleman EJ, Ozark PA, Smith ER, Shilatifard A.

Sci Adv. 2018 Jan 31;4(1):eaap8747. doi: 10.1126/sciadv.aap8747. eCollection 2018 Jan.

14.

A Carcinogen-induced mouse model recapitulates the molecular alterations of human muscle invasive bladder cancer.

Fantini D, Glaser AP, Rimar KJ, Wang Y, Schipma M, Varghese N, Rademaker A, Behdad A, Yellapa A, Yu Y, Sze CC, Wang L, Zhao Z, Crawford SE, Hu D, Licht JD, Collings CK, Bartom E, Theodorescu D, Shilatifard A, Meeks JJ.

Oncogene. 2018 Apr;37(14):1911-1925. doi: 10.1038/s41388-017-0099-6. Epub 2018 Jan 25.

15.

A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism.

Wang L, Collings CK, Zhao Z, Cozzolino KA, Ma Q, Liang K, Marshall SA, Sze CC, Hashizume R, Savas JN, Shilatifard A.

Genes Dev. 2017 Oct 15;31(20):2056-2066. doi: 10.1101/gad.306092.117. Epub 2017 Nov 14.

16.

A cryptic Tudor domain links BRWD2/PHIP to COMPASS-mediated histone H3K4 methylation.

Morgan MAJ, Rickels RA, Collings CK, He X, Cao K, Herz HM, Cozzolino KA, Abshiru NA, Marshall SA, Rendleman EJ, Sze CC, Piunti A, Kelleher NL, Savas JN, Shilatifard A.

Genes Dev. 2017 Oct 1;31(19):2003-2014. doi: 10.1101/gad.305201.117.

17.

Histone H3K4 monomethylation catalyzed by Trr and mammalian COMPASS-like proteins at enhancers is dispensable for development and viability.

Rickels R, Herz HM, Sze CC, Cao K, Morgan MA, Collings CK, Gause M, Takahashi YH, Wang L, Rendleman EJ, Marshall SA, Krueger A, Bartom ET, Piunti A, Smith ER, Abshiru NA, Kelleher NL, Dorsett D, Shilatifard A.

Nat Genet. 2017 Nov;49(11):1647-1653. doi: 10.1038/ng.3965. Epub 2017 Oct 2.

18.

Histone H3K4 methylation-dependent and -independent functions of Set1A/COMPASS in embryonic stem cell self-renewal and differentiation.

Sze CC, Cao K, Collings CK, Marshall SA, Rendleman EJ, Ozark PA, Chen FX, Morgan MA, Wang L, Shilatifard A.

Genes Dev. 2017 Sep 1;31(17):1732-1737. doi: 10.1101/gad.303768.117. Epub 2017 Sep 22.

19.

PAF1 regulation of promoter-proximal pause release via enhancer activation.

Chen FX, Xie P, Collings CK, Cao K, Aoi Y, Marshall SA, Rendleman EJ, Ugarenko M, Ozark PA, Zhang A, Shiekhattar R, Smith ER, Zhang MQ, Shilatifard A.

Science. 2017 Sep 22;357(6357):1294-1298. doi: 10.1126/science.aan3269. Epub 2017 Aug 31.

20.

Human TFIIH Kinase CDK7 Regulates Transcription-Associated Chromatin Modifications.

Ebmeier CC, Erickson B, Allen BL, Allen MA, Kim H, Fong N, Jacobsen JR, Liang K, Shilatifard A, Dowell RD, Old WM, Bentley DL, Taatjes DJ.

Cell Rep. 2017 Aug 1;20(5):1173-1186. doi: 10.1016/j.celrep.2017.07.021.

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