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Design, Synthesis, and Biological Evaluation of Substituted 4,6-Dihydrospiro[[1,2,3]triazolo[4,5-b]pyridine-7,3'-indoline]-2',5(3H)-dione Analogues as Potent NS4B Inhibitors for the Treatment of Dengue Virus Infection.

Xu J, Xie X, Ye N, Zou J, Chen H, White MA, Shi PY, Zhou J.

J Med Chem. 2019 Aug 12. doi: 10.1021/acs.jmedchem.9b00698. [Epub ahead of print]


Inter- and intra-lineage genetic diversity of wild-type Zika viruses reveals both common and distinctive nucleotide variants and clusters of genomic diversity.

Collins ND, Widen SG, Li L, Swetnam DM, Shi PY, Tesh RB, Sarathy VV.

Emerg Microbes Infect. 2019;8(1):1126-1138. doi: 10.1080/22221751.2019.1645572.


Axl Promotes Zika Virus Entry and Modulates the Antiviral State of Human Sertoli Cells.

Strange DP, Jiyarom B, Pourhabibi Zarandi N, Xie X, Baker C, Sadri-Ardekani H, Shi PY, Verma S.

MBio. 2019 Jul 16;10(4). pii: e01372-19. doi: 10.1128/mBio.01372-19.


Replication-Defective West Nile Virus with NS1 Deletion as a New Vaccine Platform for Flavivirus.

Li N, Zhang YN, Deng CL, Shi PY, Yuan ZM, Zhang B.

J Virol. 2019 Aug 13;93(17). pii: e00720-19. doi: 10.1128/JVI.00720-19. Print 2019 Sep 1.


Genetic and biochemical characterizations of Zika virus NS2A protein.

Zhang X, Xie X, Zou J, Xia H, Shan C, Chen X, Shi PY.

Emerg Microbes Infect. 2019;8(1):585-602. doi: 10.1080/22221751.2019.1598291.


Erratum for Chen et al., "Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate".

Chen Q, Wu J, Ye Q, Ma F, Zhu Q, Wu Y, Shan C, Xie X, Li D, Zhan X, Li C, Li XF, Qin X, Zhao T, Wu H, Shi PY, Man J, Qin CF.

MBio. 2019 Apr 2;10(2). pii: e00433-19. doi: 10.1128/mBio.00433-19. No abstract available.


A survey of core replacements in indole-based HIV-1 attachment inhibitors.

Wang T, Wallace OB, Zhang Z, Fang H, Yang Z, Robinson BA, Spicer TP, Gong YF, Blair WS, Shi PY, Lin PF, Deshpande M, Meanwell NA, Kadow JF.

Bioorg Med Chem Lett. 2019 Jun 1;29(11):1423-1429. doi: 10.1016/j.bmcl.2019.03.018. Epub 2019 Mar 28.


Aedes mosquitoes acquire and transmit Zika virus by breeding in contaminated aquatic environments.

Du S, Liu Y, Liu J, Zhao J, Champagne C, Tong L, Zhang R, Zhang F, Qin CF, Ma P, Chen CH, Liang G, Liu Q, Shi PY, Cazelles B, Wang P, Tian H, Cheng G.

Nat Commun. 2019 Mar 22;10(1):1324. doi: 10.1038/s41467-019-09256-0.


Use of the immunoglobulin G avidity assay to differentiate between recent Zika and past dengue virus infections.

Furuya AKM, Hunt D, George KS, Dupuis AP 2nd, Kramer LD, Shi PY, Wong S.

Clin Sci (Lond). 2019 Apr 4;133(7):859-867. doi: 10.1042/CS20180874. Print 2019 Apr 15.


Anti-Zika virus RNAi in neural progenitor cells.

Xie X, Shi PY.

Cell Res. 2019 Apr;29(4):261-262. doi: 10.1038/s41422-019-0158-3. No abstract available.


Strategies for Zika drug discovery.

Zou J, Shi PY.

Curr Opin Virol. 2019 Apr;35:19-26. doi: 10.1016/j.coviro.2019.01.005. Epub 2019 Mar 7. Review.


Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA.

Soto-Acosta R, Xie X, Shan C, Baker CK, Shi PY, Rossi SL, Garcia-Blanco MA, Bradrick S.

Elife. 2018 Dec 4;7. pii: e39023. doi: 10.7554/eLife.39023.


Zika Virus Epidemic in Brazil. II. Post-Mortem Analyses of Neonates with Microcephaly, Stillbirths, and Miscarriage.

Azevedo RSS, Araujo MT, Oliveira CS, Filho AJM, Nunes BTD, Henriques DF, Silva EVP, Carvalho VL, Chiang JO, Martins LC, Vasconcelos BCB, Sousa JR, Araujo FMC, Ribeiro EM, Castro ARP, de Queiroz MGL, Verotti MP, Nunes MRT, Cruz ACR, Rodrigues SG, Shi PY, Quaresma JAS, Tesh RB, Vasconcelos PFC.

J Clin Med. 2018 Nov 28;7(12). pii: E496. doi: 10.3390/jcm7120496.


Author Correction: Antiviral agents: Targeting vesicle size.

Fei Z, Shi PY.

Nat Mater. 2018 Dec;17(12):1164. doi: 10.1038/s41563-018-0237-8.


Targeting the Achilles Heel of Mosquito-Borne Viruses for Antiviral Therapy.

Jackman JA, Shi PY, Cho NJ.

ACS Infect Dis. 2019 Jan 11;5(1):4-8. doi: 10.1021/acsinfecdis.8b00286. Epub 2018 Nov 2.


Targeting vesicle size.

Zou J, Shi PY.

Nat Mater. 2018 Nov;17(11):955-956. doi: 10.1038/s41563-018-0200-8. No abstract available. Erratum in: Nat Mater. 2018 Dec;17(12):1164.


A Single-Dose Live-Attenuated Zika Virus Vaccine with Controlled Infection Rounds that Protects against Vertical Transmission.

Xie X, Kum DB, Xia H, Luo H, Shan C, Zou J, Muruato AE, Medeiros DBA, Nunes BTD, Dallmeier K, Rossi SL, Weaver SC, Neyts J, Wang T, Vasconcelos PFC, Shi PY.

Cell Host Microbe. 2018 Oct 10;24(4):487-499.e5. doi: 10.1016/j.chom.2018.09.008.


Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection.

Luo H, Winkelmann ER, Zhu S, Ru W, Mays E, Silvas JA, Vollmer LL, Gao J, Peng BH, Bopp NE, Cromer C, Shan C, Xie G, Li G, Tesh R, Popov VL, Shi PY, Sun SC, Wu P, Klein RS, Tang SJ, Zhang W, Aguilar PV, Wang T.

J Clin Invest. 2018 Nov 1;128(11):4980-4991. doi: 10.1172/JCI99902. Epub 2018 Sep 24.


Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate.

Chen Q, Wu J, Ye Q, Ma F, Zhu Q, Wu Y, Shan C, Xie X, Li D, Zhan X, Li C, Li XF, Qin X, Zhao T, Wu H, Shi PY, Man J, Qin CF.

MBio. 2018 Sep 18;9(5). pii: e01683-18. doi: 10.1128/mBio.01683-18. Erratum in: MBio. 2019 Apr 2;10(2):. Zhao, Tongyang [corrected to Zhao, Tongyan].


High-Throughput Fitness Profiling of Zika Virus E Protein Reveals Different Roles for Glycosylation during Infection of Mammalian and Mosquito Cells.

Gong D, Zhang TH, Zhao D, Du Y, Chapa TJ, Shi Y, Wang L, Contreras D, Zeng G, Shi PY, Wu TT, Arumugaswami V, Sun R.

iScience. 2018 Mar 23;1:97-111. doi: 10.1016/j.isci.2018.02.005. Epub 2018 Mar 23.

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