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Items: 1 to 20 of 48

1.

A highly conserved δ-opioid receptor region determines RGS4 interaction.

Karoussiotis C, Marti-Solano M, Stepniewski TM, Symeonof A, Selent J, Georgoussi Z.

FEBS J. 2019 Aug 6. doi: 10.1111/febs.15033. [Epub ahead of print]

PMID:
31386272
2.

The antioxidant resveratrol acts as a non-selective adenosine receptor agonist.

Sánchez-Melgar A, Albasanz JL, Guixà-González R, Saleh N, Selent J, Martín M.

Free Radic Biol Med. 2019 May 1;135:261-273. doi: 10.1016/j.freeradbiomed.2019.03.019. Epub 2019 Mar 18.

PMID:
30898665
3.

Synthesis, molecular modelling studies and biological evaluation of new oxoeicosanoid receptor 1 agonists.

Stepniewski TM, Torrens-Fontanals M, Rodríguez-Espigares I, Giorgino T, Primdahl KG, Vik A, Stenstrøm Y, Selent J, Hansen TV.

Bioorg Med Chem. 2018 Jul 23;26(12):3580-3587. doi: 10.1016/j.bmc.2018.05.036. Epub 2018 May 23.

PMID:
29866479
4.

Protein-Protein Docking in Drug Design and Discovery.

Kaczor AA, Bartuzi D, Stępniewski TM, Matosiuk D, Selent J.

Methods Mol Biol. 2018;1762:285-305. doi: 10.1007/978-1-4939-7756-7_15.

PMID:
29594778
5.

Challenges and Opportunities in Drug Discovery of Biased Ligands.

Rodríguez-Espigares I, Kaczor AA, Stepniewski TM, Selent J.

Methods Mol Biol. 2018;1705:321-334. doi: 10.1007/978-1-4939-7465-8_14. Review.

PMID:
29188569
6.

Serotonin 2A receptor disulfide bridge integrity is crucial for ligand binding to different signalling states but not for its homodimerization.

Iglesias A, Cimadevila M, la Fuente RA, Martí-Solano M, Cadavid MI, Castro M, Selent J, Loza MI, Brea J.

Eur J Pharmacol. 2017 Nov 15;815:138-146. doi: 10.1016/j.ejphar.2017.09.011. Epub 2017 Sep 9.

PMID:
28899696
7.

Development of Fluorescent Probes that Target Serotonin 5-HT2B Receptors.

Azuaje J, López P, Iglesias A, de la Fuente RA, Pérez-Rubio JM, García D, Stępniewski TM, García-Mera X, Brea JM, Selent J, Pérez D, Castro M, Loza MI, Sotelo E.

Sci Rep. 2017 Sep 7;7(1):10765. doi: 10.1038/s41598-017-11370-2.

8.

Membrane cholesterol effect on the 5-HT2A receptor: Insights into the lipid-induced modulation of an antipsychotic drug target.

Ramírez-Anguita JM, Rodríguez-Espigares I, Guixà-González R, Bruno A, Torrens-Fontanals M, Varela-Rial A, Selent J.

Biotechnol Appl Biochem. 2018 Jan;65(1):29-37. doi: 10.1002/bab.1608. Epub 2017 Oct 2.

PMID:
28877377
9.

Role of palmitoylation of cysteine 415 in functional coupling CB1 receptor to Gαi2 protein.

Oddi S, Totaro A, Scipioni L, Dufrusine B, Stepniewski TM, Selent J, Maccarrone M, Dainese E.

Biotechnol Appl Biochem. 2018 Jan;65(1):16-20. doi: 10.1002/bab.1575. Epub 2017 Aug 15.

PMID:
28722168
10.

Membrane cholesterol access into a G-protein-coupled receptor.

Guixà-González R, Albasanz JL, Rodriguez-Espigares I, Pastor M, Sanz F, Martí-Solano M, Manna M, Martinez-Seara H, Hildebrand PW, Martín M, Selent J.

Nat Commun. 2017 Feb 21;8:14505. doi: 10.1038/ncomms14505.

11.

C-edge loops of arrestin function as a membrane anchor.

Lally CC, Bauer B, Selent J, Sommer ME.

Nat Commun. 2017 Feb 21;8:14258. doi: 10.1038/ncomms14258.

12.

Palmitoylation of cysteine 415 of CB1 receptor affects ligand-stimulated internalization and selective interaction with membrane cholesterol and caveolin 1.

Oddi S, Stepniewski TM, Totaro A, Selent J, Scipioni L, Dufrusine B, Fezza F, Dainese E, Maccarrone M.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 May;1862(5):523-532. doi: 10.1016/j.bbalip.2017.02.004. Epub 2017 Feb 12.

PMID:
28215712
13.

In silico Exploration of the Conformational Universe of GPCRs.

Rodríguez-Espigares I, Kaczor AA, Selent J.

Mol Inform. 2016 Jul;35(6-7):227-37. doi: 10.1002/minf.201600012. Epub 2016 May 27. Review.

PMID:
27492237
14.

Computational methods for studying G protein-coupled receptors (GPCRs).

Kaczor AA, Rutkowska E, Bartuzi D, Targowska-Duda KM, Matosiuk D, Selent J.

Methods Cell Biol. 2016;132:359-99. doi: 10.1016/bs.mcb.2015.11.002. Epub 2015 Dec 24.

PMID:
26928552
15.

Drugging specific conformational states of GPCRs: challenges and opportunities for computational chemistry.

Martí-Solano M, Schmidt D, Kolb P, Selent J.

Drug Discov Today. 2016 Apr;21(4):625-31. doi: 10.1016/j.drudis.2016.01.009. Epub 2016 Jan 25. Review.

PMID:
26821135
16.

Membrane omega-3 fatty acids modulate the oligomerisation kinetics of adenosine A2A and dopamine D2 receptors.

Guixà-González R, Javanainen M, Gómez-Soler M, Cordobilla B, Domingo JC, Sanz F, Pastor M, Ciruela F, Martinez-Seara H, Selent J.

Sci Rep. 2016 Jan 22;6:19839. doi: 10.1038/srep19839.

17.

Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory.

Cournia Z, Allen TW, Andricioaei I, Antonny B, Baum D, Brannigan G, Buchete NV, Deckman JT, Delemotte L, Del Val C, Friedman R, Gkeka P, Hege HC, Hénin J, Kasimova MA, Kolocouris A, Klein ML, Khalid S, Lemieux MJ, Lindow N, Roy M, Selent J, Tarek M, Tofoleanu F, Vanni S, Urban S, Wales DJ, Smith JC, Bondar AN.

J Membr Biol. 2015 Aug;248(4):611-40. doi: 10.1007/s00232-015-9802-0. Epub 2015 Jun 11. Review.

18.

Multi-Component Protein - Protein Docking Based Protocol with External Scoring for Modeling Dimers of G Protein-Coupled Receptors.

Kaczor AA, Guixà-González R, Carrió P, Poso A, Dove S, Pastor M, Selent J.

Mol Inform. 2015 Apr;34(4):246-55. doi: 10.1002/minf.201400088. Epub 2015 Mar 27.

PMID:
27490170
19.

Detection of new biased agonists for the serotonin 5-HT2A receptor: modeling and experimental validation.

Martí-Solano M, Iglesias A, de Fabritiis G, Sanz F, Brea J, Loza MI, Pastor M, Selent J.

Mol Pharmacol. 2015 Apr;87(4):740-6. doi: 10.1124/mol.114.097022. Epub 2015 Feb 6.

PMID:
25661038
20.

A dynamic view of molecular switch behavior at serotonin receptors: implications for functional selectivity.

Martí-Solano M, Sanz F, Pastor M, Selent J.

PLoS One. 2014 Oct 14;9(10):e109312. doi: 10.1371/journal.pone.0109312. eCollection 2014.

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