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Items: 1 to 20 of 111


Linoleic Acid Metabolite DiHOME Decreases Post-ischemic Cardiac Recovery in Murine Hearts.

Bannehr M, Löhr L, Gelep J, Haverkamp W, Schunck WH, Gollasch M, Wutzler A.

Cardiovasc Toxicol. 2019 Feb 6. doi: 10.1007/s12012-019-09508-x. [Epub ahead of print]


Chiral lipidomics of monoepoxy and monohydroxy metabolites derived from long-chain polyunsaturated fatty acids.

Blum M, Dogan I, Karber M, Rothe M, Schunck WH.

J Lipid Res. 2019 Jan;60(1):135-148. doi: 10.1194/jlr.M089755. Epub 2018 Nov 8.


Possible Role of CYP450 Generated Omega-3/Omega-6 PUFA Metabolites in the Modulation of Blood Pressure and Vascular Function in Obese Children.

Bonafini S, Giontella A, Tagetti A, Marcon D, Montagnana M, Benati M, Gaudino R, Cavarzere P, Karber M, Rothe M, Minuz P, Antonazzi F, Maffeis C, Schunck WH, Fava C.

Nutrients. 2018 Nov 5;10(11). pii: E1689. doi: 10.3390/nu10111689.


Therapeutic potential of omega-3 fatty acid-derived epoxyeicosanoids in cardiovascular and inflammatory diseases.

Schunck WH, Konkel A, Fischer R, Weylandt KH.

Pharmacol Ther. 2018 Mar;183:177-204. doi: 10.1016/j.pharmthera.2017.10.016. Epub 2017 Nov 7. Review.


Hypoxia-reoxygenation enhances murine afferent arteriolar vasoconstriction by angiotensin II.

Pahlitzsch T, Liu ZZ, Al-Masri A, Braun D, Dietze S, Persson PB, Schunck WH, Blum M, Kupsch E, Ludwig M, Patzak A.

Am J Physiol Renal Physiol. 2018 Mar 1;314(3):F430-F438. doi: 10.1152/ajprenal.00252.2017. Epub 2017 Oct 25.


Cytochrome P450 monooxygenase lipid metabolites are significant second messengers in the resolution of choroidal neovascularization.

Hasegawa E, Inafuku S, Mulki L, Okunuki Y, Yanai R, Smith KE, Kim CB, Klokman G, Bielenberg DR, Puli N, Falck JR, Husain D, Miller JW, Edin ML, Zeldin DC, Lee KSS, Hammock BD, Schunck WH, Connor KM.

Proc Natl Acad Sci U S A. 2017 Sep 5;114(36):E7545-E7553. doi: 10.1073/pnas.1620898114. Epub 2017 Aug 21.


Role of Müller cell cytochrome P450 2c44 in murine retinal angiogenesis.

Hu J, Geyer A, Dziumbla S, Awwad K, Zeldin DC, Schunck WH, Popp R, Frömel T, Fleming I.

Prostaglandins Other Lipid Mediat. 2017 Nov;133:93-102. doi: 10.1016/j.prostaglandins.2017.04.002. Epub 2017 Apr 23.


Dietary Omega-3 Polyunsaturated Fatty Acids Prevent Vascular Dysfunction and Attenuate Cytochrome P4501A1 Expression by 2,3,7,8-Tetrachlorodibenzo-P-Dioxin.

Wiest EF, Walsh-Wilcox MT, Rothe M, Schunck WH, Walker MK.

Toxicol Sci. 2016 Nov;154(1):43-54. Epub 2016 Aug 4.


Vasopressin lowers renal epoxyeicosatrienoic acid levels by activating soluble epoxide hydrolase.

Boldt C, Röschel T, Himmerkus N, Plain A, Bleich M, Labes R, Blum M, Krause H, Magheli A, Giesecke T, Mutig K, Rothe M, Weldon SM, Dragun D, Schunck WH, Bachmann S, Paliege A.

Am J Physiol Renal Physiol. 2016 Dec 1;311(6):F1198-F1210. doi: 10.1152/ajprenal.00062.2016. Epub 2016 Sep 28.


EPA and/or DHA? A test question on the principles and opportunities in utilizing the therapeutic potential of omega-3 fatty acids.

Schunck WH.

J Lipid Res. 2016 Sep;57(9):1608-11. doi: 10.1194/jlr.C071084. Epub 2016 Jul 19. No abstract available.


Activation of Peroxisome Proliferator-Activated Receptor-δ as Novel Therapeutic Strategy to Prevent In-Stent Restenosis and Stent Thrombosis.

Hytönen J, Leppänen O, Braesen JH, Schunck WH, Mueller D, Jung F, Mrowietz C, Jastroch M, von Bergwelt-Baildon M, Kappert K, Heuser A, Drenckhahn JD, Pieske B, Thierfelder L, Ylä-Herttuala S, Blaschke F.

Arterioscler Thromb Vasc Biol. 2016 Aug;36(8):1534-48. doi: 10.1161/ATVBAHA.115.306962. Epub 2016 Jun 9.


Renal Ischemia/Reperfusion Injury in Soluble Epoxide Hydrolase-Deficient Mice.

Zhu Y, Blum M, Hoff U, Wesser T, Fechner M, Westphal C, Gürgen D, Catar RA, Philippe A, Wu K, Bubalo G, Rothe M, Weldon SM, Dragun D, Schunck WH.

PLoS One. 2016 Jan 4;11(1):e0145645. doi: 10.1371/journal.pone.0145645. eCollection 2016.


Epoxides Derived from Dietary Dihomo-Gamma-Linolenic Acid Induce Germ Cell Death in C. elegans.

Deline M, Keller J, Rothe M, Schunck WH, Menzel R, Watts JL.

Sci Rep. 2015 Oct 21;5:15417. doi: 10.1038/srep15417.


Role of CYP eicosanoids in the regulation of pharyngeal pumping and food uptake in Caenorhabditis elegans.

Zhou Y, Falck JR, Rothe M, Schunck WH, Menzel R.

J Lipid Res. 2015 Nov;56(11):2110-23. doi: 10.1194/jlr.M061887. Epub 2015 Sep 23.


Cytochrome p450 enzymes in the bioactivation of polyunsaturated Fatty acids and their role in cardiovascular disease.

Westphal C, Konkel A, Schunck WH.

Adv Exp Med Biol. 2015;851:151-87. doi: 10.1007/978-3-319-16009-2_6. Review.


Interaction of epoxyeicosatrienoic acids and adipocyte fatty acid-binding protein in the modulation of cardiomyocyte contractility.

Lamounier-Zepter V, Look C, Schunck WH, Schlottmann I, Woischwill C, Bornstein SR, Xu A, Morano I.

Int J Obes (Lond). 2015 May;39(5):755-61. doi: 10.1038/ijo.2014.193. Epub 2014 Nov 5.


Role of CYP1A1 in modulating the vascular and blood pressure benefits of omega-3 polyunsaturated fatty acids.

Agbor LN, Wiest EF, Rothe M, Schunck WH, Walker MK.

J Pharmacol Exp Ther. 2014 Dec;351(3):688-98. doi: 10.1124/jpet.114.219535. Epub 2014 Oct 14.


CYP-13A12 of the nematode Caenorhabditis elegans is a PUFA-epoxygenase involved in behavioural response to reoxygenation.

Keller J, Ellieva A, Ma DK, Ju J, Nehk E, Konkel A, Falck JR, Schunck WH, Menzel R.

Biochem J. 2014 Nov 15;464(1):61-71. doi: 10.1042/BJ20140848.


Cytochrome P450-generated metabolites derived from ω-3 fatty acids attenuate neovascularization.

Yanai R, Mulki L, Hasegawa E, Takeuchi K, Sweigard H, Suzuki J, Gaissert P, Vavvas DG, Sonoda KH, Rothe M, Schunck WH, Miller JW, Connor KM.

Proc Natl Acad Sci U S A. 2014 Jul 1;111(26):9603-8. doi: 10.1073/pnas.1401191111. Epub 2014 Jun 16.


The biological actions of 11,12-epoxyeicosatrienoic acid in endothelial cells are specific to the R/S-enantiomer and require the G(s) protein.

Ding Y, Frömel T, Popp R, Falck JR, Schunck WH, Fleming I.

J Pharmacol Exp Ther. 2014 Jul;350(1):14-21. doi: 10.1124/jpet.114.214254. Epub 2014 Apr 24.

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