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Costunolide and dehydrocostuslactone from Saussurea lappa root inhibit autophagy in hepatocellular carcinoma cells.
Okubo S, Ohta T, Fujita H, Shoyama Y, Uto T. Okubo S, et al. J Nat Med. 2021 Jan;75(1):240-245. doi: 10.1007/s11418-020-01462-1. Epub 2020 Nov 6. J Nat Med. 2021. PMID: 33159250
Our preliminary screening confirmed that an extract from the root of Saussurea lappa remarkably suppressed the proliferation of HepG2 hepatocellular carcinoma cells and inhibited autophagy. ...
Our preliminary screening confirmed that an extract from the root of Saussurea lappa remarkably suppressed the prolifer …
Investigation of the Antiviral Effects of Saussurea lappa Root Extract against SARS-CoV-2 Virus.
Ulbegi Polat H, Serhatli M, Taş Ekiz A, Abaci İ, Aksoy Ö, Çakirca G, Tekin Ş, Al-Zendani AAH, Al-Zendani MAA, Korkmaz Ö, Peru C. Ulbegi Polat H, et al. Mol Nutr Food Res. 2023 Jul;67(14):e2200804. doi: 10.1002/mnfr.202200804. Epub 2023 May 25. Mol Nutr Food Res. 2023. PMID: 37170075
SCOPE: The purpose of this study was to look into the antiviral activity of a plant extract derived from the roots of the Saussurea lappa as a food supplement against SARS-CoV-2 infection. METHODS AND RESULTS: Vero E6 cells are employed in the study to …
SCOPE: The purpose of this study was to look into the antiviral activity of a plant extract derived from the roots of the S …
Ameliorative effects of Saussurea lappa root aqueous extract against Ethephon-induced reproductive toxicity in male rats.
Abd Eldaim MA, Tousson E, El Sayed IET, Awd WM. Abd Eldaim MA, et al. Environ Toxicol. 2019 Feb;34(2):150-159. doi: 10.1002/tox.22669. Epub 2018 Oct 13. Environ Toxicol. 2019. PMID: 30315693
This study was designed to evaluate protective effect of Saussurea lappa root aqueous extract against Ethephon (2-chloroethylphosphonic acid)-induced reproductive toxicity in rats. ...Fourth, fifth, and sixth groups were given S. lappa extract before, …
This study was designed to evaluate protective effect of Saussurea lappa root aqueous extract against Ethephon (2-chlor …
Impact of Saussurea lappa root extract against copper oxide nanoparticles induced oxidative stress and toxicity in rat cardiac tissues.
Tousson E, El-Gharbawy DM. Tousson E, et al. Environ Toxicol. 2023 Feb;38(2):415-421. doi: 10.1002/tox.23688. Epub 2022 Oct 26. Environ Toxicol. 2023. PMID: 36286243
Conversely, statistical significant decreases were detected in cardiac reduced glutathione, catalase, and superoxide dismutase in CuO NPs group as compared with control group. Interestingly, treatment of CuO NPs with costus root extract was associated with significant impr …
Conversely, statistical significant decreases were detected in cardiac reduced glutathione, catalase, and superoxide dismutase in CuO NPs gr …
Modulatory effects of Saussurea lappa root aqueous extract against ethephon-induced kidney toxicity in male rats.
Tousson E, El-Atrsh A, Mansour M, Abdallah A. Tousson E, et al. Environ Toxicol. 2019 Dec;34(12):1277-1284. doi: 10.1002/tox.22828. Epub 2019 Aug 8. Environ Toxicol. 2019. PMID: 31392797
Medicinal plants are sources of novel drug discovery targets. Costus (Saussurea lappa) has been used as traditional Chinese medicine. The current study was conducted to examine the possible modifying effects of costus (S. lappa) root aqueous extract ag …
Medicinal plants are sources of novel drug discovery targets. Costus (Saussurea lappa) has been used as traditional Chinese me …
Saussurea lappa root extract ameliorates the hazards effect of thorium induced oxidative stress and neuroendocrine alterations in adult male rats.
Abdel-Rahman M, Rezk MM, Ahmed-Farid OA, Essam S, Abdel Moneim AE. Abdel-Rahman M, et al. Environ Sci Pollut Res Int. 2020 Apr;27(12):13237-13246. doi: 10.1007/s11356-020-07917-y. Epub 2020 Feb 3. Environ Sci Pollut Res Int. 2020. PMID: 32016872
The present study was aimed to estimating the effect of Saussurea lappa (costus) root extract on thorium accumulation in different brain regions (cerebral cortex, cerebellum, and hypothalamus) of adult male albino rats and also to evaluate the antioxidant eff …
The present study was aimed to estimating the effect of Saussurea lappa (costus) root extract on thorium accumulation i …
Aqueous extract of Saussurea lappa root ameliorate oxidative myocardial injury induced by isoproterenol in rats.
Saleem TS, Lokanath N, Prasanthi A, Madhavi M, Mallika G, Vishnu MN. Saleem TS, et al. J Adv Pharm Technol Res. 2013 Apr;4(2):94-100. doi: 10.4103/2231-4040.111525. J Adv Pharm Technol Res. 2013. PMID: 23833749 Free PMC article.
Saussurea lappa Clarke (Compositae), is commonly known as Kushta. In Ayurvedha, it is mentioned that the aqueous extract of the root S. lappa was used for treatment of angina pectoris. The present study was designed to investigate the cardioprotective …
Saussurea lappa Clarke (Compositae), is commonly known as Kushta. In Ayurvedha, it is mentioned that the aqueous extract of th …
Cytotoxic sesquiterpene lactones from the root of Saussurea lappa.
Sun CM, Syu WJ, Don MJ, Lu JJ, Lee GH. Sun CM, et al. J Nat Prod. 2003 Sep;66(9):1175-80. doi: 10.1021/np030147e. J Nat Prod. 2003. PMID: 14510592
Bioassay-directed fractionation of Saussurea lappa led to the isolation of a novel lappadilactone (1) and seven sesquiterpene lactones (2-8) as cytotoxic principles against selected human cancer cell lines. ...
Bioassay-directed fractionation of Saussurea lappa led to the isolation of a novel lappadilactone (1) and seven sesquiterpene …
Evaluation of anti-resistant activity of Auklandia (Saussurea lappa) root against some human pathogens.
Hasson SS, Al-Balushi MS, Alharthy K, Al-Busaidi JZ, Aldaihani MS, Othman MS, Said EA, Habal O, Sallam TA, Aljabri AA, Ahmedidris M. Hasson SS, et al. Asian Pac J Trop Biomed. 2013 Jul;3(7):557-62. doi: 10.1016/S2221-1691(13)60113-6. Asian Pac J Trop Biomed. 2013. PMID: 23836413 Free PMC article.
OBJECTIVE: The antimicrobial activity of the ethanol extract of the Auklandia (Saussurea lappa)root plant was investigated to verify its medicinal use in the treatment of microbial infections. ...CONCLUSION: The results demonstrated that the crude etha …
OBJECTIVE: The antimicrobial activity of the ethanol extract of the Auklandia (Saussurea lappa)root plant was in …
A new sesquiterpenoid from Saussurea lappa roots.
Cao K, Qian W, Xu Y, Zhou Z, Zhang Q, Zhang X. Cao K, et al. Nat Prod Res. 2016 Oct;30(19):2160-3. doi: 10.1080/14786419.2016.1149708. Epub 2016 Mar 8. Nat Prod Res. 2016. PMID: 26956664
A new sesquiterpenoid, 10alpha-methoxyartemisinic acid (1) was isolated from Saussurea lappa roots along with two known compounds, costunolide (2) and dehydrocostus lactone (3) by high-speed countercurrent chromatography with purities of 85, 95 and 98%, respe …
A new sesquiterpenoid, 10alpha-methoxyartemisinic acid (1) was isolated from Saussurea lappa roots along with two known …
149 results