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Neuroprotection: Pro-survival and Anti-neurotoxic Mechanisms as Therapeutic Strategies in Neurodegeneration.

Saragovi HU, Galan A, Levin LA.

Front Cell Neurosci. 2019 Jun 6;13:231. doi: 10.3389/fncel.2019.00231. eCollection 2019. Review.


Pharmacological interrogation of TrkA-mediated mechanisms in hippocampal-dependent memory consolidation.

Josephy-Hernandez S, Pirvulescu I, Maira M, Aboulkassim T, Wong TP, McKinney RA, Saragovi HU.

PLoS One. 2019 Jun 24;14(6):e0218036. doi: 10.1371/journal.pone.0218036. eCollection 2019.


Vaccination with Tumor-Ganglioside Glycomimetics Activates a Selective Immunity that Affords Cancer Therapy.

Tong W, Maira M, Roychoudhury R, Galan A, Brahimi F, Gilbert M, Cunningham AM, Josephy S, Pirvulescu I, Moffett S, Saragovi HU.

Cell Chem Biol. 2019 Apr 10. pii: S2451-9456(19)30114-X. doi: 10.1016/j.chembiol.2019.03.018. [Epub ahead of print]


The route of administration influences the therapeutic index of an anti-proNGF neutralizing mAb for experimental treatment of Diabetic Retinopathy.

Barcelona PF, Galan A, Nedev H, Jian Y, Sarunic MV, Saragovi HU.

PLoS One. 2018 Jun 21;13(6):e0199079. doi: 10.1371/journal.pone.0199079. eCollection 2018.


UNG-1 and APN-1 are the major enzymes to efficiently repair 5-hydroxymethyluracil DNA lesions in C. elegans.

Papaluca A, Wagner JR, Saragovi HU, Ramotar D.

Sci Rep. 2018 May 1;8(1):6860. doi: 10.1038/s41598-018-25124-1.


Inhibition of CD45 Phosphatase Activity Induces Cell Cycle Arrest and Apoptosis of CD45+ Lymphoid Tumors Ex Vivo and In Vivo.

Perron M, Saragovi HU.

Mol Pharmacol. 2018 Jun;93(6):575-580. doi: 10.1124/mol.117.110908. Epub 2018 Mar 19.


In retinitis pigmentosa TrkC.T1-dependent vectorial Erk activity upregulates glial TNF-α, causing selective neuronal death.

Galán A, Jmaeff S, Barcelona PF, Brahimi F, Sarunic MV, Saragovi HU.

Cell Death Dis. 2017 Dec 14;8(12):3222. doi: 10.1038/s41419-017-0074-8.


p75NTR antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa.

Platón-Corchado M, Barcelona PF, Jmaeff S, Marchena M, Hernández-Pinto AM, Hernández-Sánchez C, Saragovi HU, de la Rosa EJ.

Cell Death Dis. 2017 Jul 13;8(7):e2922. doi: 10.1038/cddis.2017.306.


Subconjunctival Delivery of p75NTR Antagonists Reduces the Inflammatory, Vascular, and Neurodegenerative Pathologies of Diabetic Retinopathy.

Galan A, Barcelona PF, Nedev H, Sarunic MV, Jian Y, Saragovi HU.

Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):2852-2862. doi: 10.1167/iovs.16-20988.


Identification of function-regulating antibodies targeting the receptor protein tyrosine phosphatase sigma ectodomain.

Wu CL, Hardy S, Aubry I, Landry M, Haggarty A, Saragovi HU, Tremblay ML.

PLoS One. 2017 May 30;12(5):e0178489. doi: 10.1371/journal.pone.0178489. eCollection 2017.


The Paradoxical Signals of Two TrkC Receptor Isoforms Supports a Rationale for Novel Therapeutic Strategies in ALS.

Brahimi F, Maira M, Barcelona PF, Galan A, Aboulkassim T, Teske K, Rogers ML, Bertram L, Wang J, Yousefi M, Rush R, Fabian M, Cashman N, Saragovi HU.

PLoS One. 2016 Oct 3;11(10):e0162307. doi: 10.1371/journal.pone.0162307. eCollection 2016.


p75NTR and Its Ligand ProNGF Activate Paracrine Mechanisms Etiological to the Vascular, Inflammatory, and Neurodegenerative Pathologies of Diabetic Retinopathy.

Barcelona PF, Sitaras N, Galan A, Esquiva G, Jmaeff S, Jian Y, Sarunic MV, Cuenca N, Sapieha P, Saragovi HU.

J Neurosci. 2016 Aug 24;36(34):8826-41. doi: 10.1523/JNEUROSCI.4278-15.2016.


Neurotrophin receptor agonists and antagonists as therapeutic agents: An evolving paradigm.

Josephy-Hernandez S, Jmaeff S, Pirvulescu I, Aboulkassim T, Saragovi HU.

Neurobiol Dis. 2017 Jan;97(Pt B):139-155. doi: 10.1016/j.nbd.2016.08.004. Epub 2016 Aug 18. Review.


Ligands Binding to Cell Surface Ganglioside GD2 Cause Src-Dependent Activation of N-Methyl-D-Aspartate Receptor Signaling and Changes in Cellular Morphology.

Tong W, Maira M, Gagnon M, Saragovi HU.

PLoS One. 2015 Aug 7;10(8):e0134255. doi: 10.1371/journal.pone.0134255. eCollection 2015.


Erratum to: Modulation of p75(NTR) prevents diabetes- and proNGF-induced retinal inflammation and blood-retina barrier breakdown in mice and rats.

Mysona BA, Al-Gayyar MM, Matragoon S, Abdelsaid MA, El-Azab MF, Saragovi HU, El-Remessy AB.

Diabetologia. 2015 Mar;58(3):644. doi: 10.1007/s00125-014-3476-5. No abstract available.


Angiotensin II type I and prostaglandin F2α receptors cooperatively modulate signaling in vascular smooth muscle cells.

Goupil E, Fillion D, Clément S, Luo X, Devost D, Sleno R, Pétrin D, Saragovi HU, Thorin É, Laporte SA, Hébert TE.

J Biol Chem. 2015 Jan 30;290(5):3137-48. doi: 10.1074/jbc.M114.631119. Epub 2014 Dec 15.


Neuronal injury external to the retina rapidly activates retinal glia, followed by elevation of markers for cell cycle re-entry and death in retinal ganglion cells.

Galan A, Dergham P, Escoll P, de-la-Hera A, D'Onofrio PM, Magharious MM, Koeberle PD, Frade JM, Saragovi HU.

PLoS One. 2014 Jul 1;9(7):e101349. doi: 10.1371/journal.pone.0101349. eCollection 2014.


Combinatorial assembly of small molecules into bivalent antagonists of TrkC or TrkA receptors.

Brahimi F, Ko E, Malakhov A, Burgess K, Saragovi HU.

PLoS One. 2014 Mar 6;9(3):e89617. doi: 10.1371/journal.pone.0089617. eCollection 2014.


Allosteric noncompetitive small molecule selective inhibitors of CD45 tyrosine phosphatase suppress T-cell receptor signals and inflammation in vivo.

Perron MD, Chowdhury S, Aubry I, Purisima E, Tremblay ML, Saragovi HU.

Mol Pharmacol. 2014 Apr;85(4):553-63. doi: 10.1124/mol.113.089847. Epub 2014 Jan 28.


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