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Items: 17


Effect of LysM+ macrophage depletion on lung pathology in mice with chronic bronchitis.

Saini Y, Lewis BW, Yu D, Dang H, Livraghi-Butrico A, Del Piero F, O'Neal WK, Boucher RC.

Physiol Rep. 2018 Apr;6(8):e13677. doi: 10.14814/phy2.13677.


Loss of β Epithelial Sodium Channel Function in Meibomian Glands Produces Pseudohypoaldosteronism 1-Like Ocular Disease in Mice.

Yu D, Saini Y, Chen G, Ghio AJ, Dang H, Burns KA, Wang Y, Davis RM, Randell SH, Esther CR Jr, Paulsen F, Boucher RC.

Am J Pathol. 2018 Jan;188(1):95-110. doi: 10.1016/j.ajpath.2017.09.016. Epub 2017 Oct 26.


Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease.

Lewis BW, Sultana R, Sharma R, Noël A, Langohr I, Patial S, Penn AL, Saini Y.

J Immunol. 2017 Aug 1;199(3):1170-1183. doi: 10.4049/jimmunol.1700144. Epub 2017 Jun 30.


Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.

Saini Y, Proper SP, Dornbos P, Greenwood KK, Kopec AK, Lynn SG, Grier E, Burgoon LD, Zacharewski TR, Thomas RS, Harkema JR, LaPres JJ.

PLoS One. 2015 Sep 30;10(9):e0139270. doi: 10.1371/journal.pone.0139270. eCollection 2015.


Neonatal Pulmonary Macrophage Depletion Coupled to Defective Mucus Clearance Increases Susceptibility to Pneumonia and Alters Pulmonary Immune Responses.

Saini Y, Wilkinson KJ, Terrell KA, Burns KA, Livraghi-Butrico A, Doerschuk CM, O'Neal WK, Boucher RC.

Am J Respir Cell Mol Biol. 2016 Feb;54(2):210-21. doi: 10.1165/rcmb.2014-0111OC.


Angiotensin II-induced hypertensive renal inflammation is mediated through HMGB1-TLR4 signaling in rat tubulo-epithelial cells.

Nair AR, Ebenezer PJ, Saini Y, Francis J.

Exp Cell Res. 2015 Jul 15;335(2):238-47. doi: 10.1016/j.yexcr.2015.05.011. Epub 2015 May 29.


Hypoxia Inducible Factors Modulate Mitochondrial Oxygen Consumption and Transcriptional Regulation of Nuclear-Encoded Electron Transport Chain Genes.

Hwang HJ, Lynn SG, Vengellur A, Saini Y, Grier EA, Ferguson-Miller SM, LaPres JJ.

Biochemistry. 2015 Jun 23;54(24):3739-48. doi: 10.1021/bi5012892. Epub 2015 Jun 12.


Gene expression in whole lung and pulmonary macrophages reflects the dynamic pathology associated with airway surface dehydration.

Saini Y, Dang H, Livraghi-Butrico A, Kelly EJ, Jones LC, O'Neal WK, Boucher RC.

BMC Genomics. 2014 Sep 10;15:726. doi: 10.1186/1471-2164-15-726.


Loss of hypoxia-inducible factor 2 alpha in the lung alveolar epithelium of mice leads to enhanced eosinophilic inflammation in cobalt-induced lung injury.

Proper SP, Saini Y, Greenwood KK, Bramble LA, Downing NJ, Harkema JR, Lapres JJ.

Toxicol Sci. 2014 Feb;137(2):447-57. doi: 10.1093/toxsci/kft253. Epub 2013 Nov 11.


Neonatal epithelial hypoxia inducible factor-1α expression regulates the response of the lung to experimental asthma.

Greenwood KK, Proper SP, Saini Y, Bramble LA, Jackson-Humbles DN, Wagner JG, Harkema JR, LaPres JJ.

Am J Physiol Lung Cell Mol Physiol. 2012 Mar 1;302(5):L455-62. doi: 10.1152/ajplung.00193.2011. Epub 2011 Dec 16.


The role of hypoxia-inducible factor-1α in acetaminophen hepatotoxicity.

Sparkenbaugh EM, Saini Y, Greenwood KK, LaPres JJ, Luyendyk JP, Copple BL, Maddox JF, Ganey PE, Roth RA.

J Pharmacol Exp Ther. 2011 Aug;338(2):492-502. doi: 10.1124/jpet.111.180521. Epub 2011 May 16.


G-protein coupled receptor kinase 5 mediates lipopolysaccharide-induced NFκB activation in primary macrophages and modulates inflammation in vivo in mice.

Patial S, Shahi S, Saini Y, Lee T, Packiriswamy N, Appledorn DM, Lapres JJ, Amalfitano A, Parameswaran N.

J Cell Physiol. 2011 May;226(5):1323-33. doi: 10.1002/jcp.22460.


Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice.

Patial S, Saini Y, Parvataneni S, Appledorn DM, Dorn GW 2nd, Lapres JJ, Amalfitano A, Senagore P, Parameswaran N.

J Cell Physiol. 2011 Mar;226(3):627-37. doi: 10.1002/jcp.22384.


Acute cobalt-induced lung injury and the role of hypoxia-inducible factor 1alpha in modulating inflammation.

Saini Y, Greenwood KK, Merrill C, Kim KY, Patial S, Parameswaran N, Harkema JR, LaPres JJ.

Toxicol Sci. 2010 Aug;116(2):673-81. doi: 10.1093/toxsci/kfq155. Epub 2010 May 28.


Role of hypoxia-inducible factor 1{alpha} in modulating cobalt-induced lung inflammation.

Saini Y, Kim KY, Lewandowski R, Bramble LA, Harkema JR, Lapres JJ.

Am J Physiol Lung Cell Mol Physiol. 2010 Feb;298(2):L139-47. doi: 10.1152/ajplung.00252.2009. Epub 2009 Nov 13.


HIF1alpha is essential for normal intrauterine differentiation of alveolar epithelium and surfactant production in the newborn lung of mice.

Saini Y, Harkema JR, LaPres JJ.

J Biol Chem. 2008 Nov 28;283(48):33650-7. doi: 10.1074/jbc.M805927200. Epub 2008 Sep 18.


Virus neutralizing antibody response in mice and dogs with a bicistronic DNA vaccine encoding rabies virus glycoprotein and canine parvovirus VP2.

Patial S, Chaturvedi VK, Rai A, Saini M, Chandra R, Saini Y, Gupta PK.

Vaccine. 2007 May 16;25(20):4020-8. Epub 2007 Mar 15.


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