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Items: 1 to 20 of 32

1.

The three-dimensional structure of an H-superfamily conotoxin reveals a granulin fold arising from a common ICK cysteine framework.

Nielsen LD, Foged MM, Albert A, Bertelsen AB, Søltoft CL, Robinson SD, Petersen SV, Purcell AW, Olivera BM, Norton RS, Vasskog T, Safavi-Hemami H, Teilum K, Ellgaard L.

J Biol Chem. 2019 May 31;294(22):8745-8759. doi: 10.1074/jbc.RA119.007491. Epub 2019 Apr 11.

PMID:
30975904
2.

Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor.

Ahorukomeye P, Disotuar MM, Gajewiak J, Karanth S, Watkins M, Robinson SD, Flórez Salcedo P, Smith NA, Smith BJ, Schlegel A, Forbes BE, Olivera B, Hung-Chieh Chou D, Safavi-Hemami H.

Elife. 2019 Feb 12;8. pii: e41574. doi: 10.7554/eLife.41574.

3.

Discovery of Novel Conotoxin Candidates Using Machine Learning.

Li Q, Watkins M, Robinson SD, Safavi-Hemami H, Yandell M.

Toxins (Basel). 2018 Dec 1;10(12). pii: E503. doi: 10.3390/toxins10120503.

4.

Ero1-Mediated Reoxidation of Protein Disulfide Isomerase Accelerates the Folding of Cone Snail Toxins.

O'Brien H, Kanemura S, Okumura M, Baskin RP, Bandyopadhyay PK, Olivera BM, Ellgaard L, Inaba K, Safavi-Hemami H.

Int J Mol Sci. 2018 Oct 31;19(11). pii: E3418. doi: 10.3390/ijms19113418.

5.

Conopeptides promote itch through human itch receptor hMgprX1.

Espino SS, Robinson SD, Safavi-Hemami H, Gajewiak J, Yang W, Olivera BM, Liu Q.

Toxicon. 2018 Nov;154:28-34. doi: 10.1016/j.toxicon.2018.09.002. Epub 2018 Sep 21.

6.

Pain therapeutics from cone snail venoms: From Ziconotide to novel non-opioid pathways.

Safavi-Hemami H, Brogan SE, Olivera BM.

J Proteomics. 2019 Jan 6;190:12-20. doi: 10.1016/j.jprot.2018.05.009. Epub 2018 May 16.

7.

Divergence of the Venom Exogene Repertoire in Two Sister Species of Turriconus.

Li Q, Barghi N, Lu A, Fedosov AE, Bandyopadhyay PK, Lluisma AO, Concepcion GP, Yandell M, Olivera BM, Safavi-Hemami H.

Genome Biol Evol. 2017 Sep 1;9(9):2211-2225. doi: 10.1093/gbe/evx157.

8.

Venom peptides as pharmacological tools and therapeutics for diabetes.

Robinson SD, Safavi-Hemami H.

Neuropharmacology. 2017 Dec;127:79-86. doi: 10.1016/j.neuropharm.2017.07.001. Epub 2017 Jul 5. Review.

PMID:
28689026
9.

Linking neuroethology to the chemical biology of natural products: interactions between cone snails and their fish prey, a case study.

Olivera BM, Raghuraman S, Schmidt EW, Safavi-Hemami H.

J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2017 Sep;203(9):717-735. doi: 10.1007/s00359-017-1183-7. Epub 2017 May 27. Review.

10.

The Venom Repertoire of Conus gloriamaris (Chemnitz, 1777), the Glory of the Sea.

Robinson SD, Li Q, Lu A, Bandyopadhyay PK, Yandell M, Olivera BM, Safavi-Hemami H.

Mar Drugs. 2017 May 20;15(5). pii: E145. doi: 10.3390/md15050145.

11.

Isolation and characterization of Conohyal-P1, a hyaluronidase from the injected venom of Conus purpurascens.

Möller C, Clark E, Safavi-Hemami H, DeCaprio A, Marí F.

J Proteomics. 2017 Jul 5;164:73-84. doi: 10.1016/j.jprot.2017.05.002. Epub 2017 May 4.

PMID:
28479398
12.

Insulin as a weapon.

Robinson SD, Safavi-Hemami H.

Toxicon. 2016 Dec 1;123:56-61. doi: 10.1016/j.toxicon.2016.10.010. Epub 2016 Oct 21. Review.

PMID:
27777069
13.

A minimized human insulin-receptor-binding motif revealed in a Conus geographus venom insulin.

Menting JG, Gajewiak J, MacRaild CA, Chou DH, Disotuar MM, Smith NA, Miller C, Erchegyi J, Rivier JE, Olivera BM, Forbes BE, Smith BJ, Norton RS, Safavi-Hemami H, Lawrence MC.

Nat Struct Mol Biol. 2016 Oct;23(10):916-920. doi: 10.1038/nsmb.3292. Epub 2016 Sep 12.

PMID:
27617429
14.

Venom Insulins of Cone Snails Diversify Rapidly and Track Prey Taxa.

Safavi-Hemami H, Lu A, Li Q, Fedosov AE, Biggs J, Showers Corneli P, Seger J, Yandell M, Olivera BM.

Mol Biol Evol. 2016 Nov;33(11):2924-2934. Epub 2016 Aug 14.

15.

Rapid expansion of the protein disulfide isomerase gene family facilitates the folding of venom peptides.

Safavi-Hemami H, Li Q, Jackson RL, Song AS, Boomsma W, Bandyopadhyay PK, Gruber CW, Purcell AW, Yandell M, Olivera BM, Ellgaard L.

Proc Natl Acad Sci U S A. 2016 Mar 22;113(12):3227-32. doi: 10.1073/pnas.1525790113. Epub 2016 Mar 8.

16.

A prominent role of PDIA6 in processing of misfolded proinsulin.

Gorasia DG, Dudek NL, Safavi-Hemami H, Perez RA, Schittenhelm RB, Saunders PM, Wee S, Mangum JE, Hubbard MJ, Purcell AW.

Biochim Biophys Acta. 2016 Jun;1864(6):715-723. doi: 10.1016/j.bbapap.2016.03.002. Epub 2016 Mar 3.

PMID:
26947243
17.

A Naturally Occurring Peptide with an Elementary Single Disulfide-Directed β-Hairpin Fold.

Robinson SD, Chhabra S, Belgi A, Chittoor B, Safavi-Hemami H, Robinson AJ, Papenfuss AT, Purcell AW, Norton RS.

Structure. 2016 Feb 2;24(2):293-9. doi: 10.1016/j.str.2015.11.015. Epub 2016 Jan 7.

18.

Hormone-like peptides in the venoms of marine cone snails.

Robinson SD, Li Q, Bandyopadhyay PK, Gajewiak J, Yandell M, Papenfuss AT, Purcell AW, Norton RS, Safavi-Hemami H.

Gen Comp Endocrinol. 2017 Apr 1;244:11-18. doi: 10.1016/j.ygcen.2015.07.012. Epub 2015 Aug 22.

19.

Insights into the origins of fish hunting in venomous cone snails from studies of Conus tessulatus.

Aman JW, Imperial JS, Ueberheide B, Zhang MM, Aguilar M, Taylor D, Watkins M, Yoshikami D, Showers-Corneli P, Safavi-Hemami H, Biggs J, Teichert RW, Olivera BM.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5087-92. doi: 10.1073/pnas.1424435112. Epub 2015 Apr 6.

20.

Specialized insulin is used for chemical warfare by fish-hunting cone snails.

Safavi-Hemami H, Gajewiak J, Karanth S, Robinson SD, Ueberheide B, Douglass AD, Schlegel A, Imperial JS, Watkins M, Bandyopadhyay PK, Yandell M, Li Q, Purcell AW, Norton RS, Ellgaard L, Olivera BM.

Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):1743-8. doi: 10.1073/pnas.1423857112. Epub 2015 Jan 20.

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