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32 results

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From bench to bedside: Calprotectin (S100A8/S100A9) as a biomarker in rheumatoid arthritis.
Inciarte-Mundo J, Frade-Sosa B, Sanmartí R. Inciarte-Mundo J, et al. Front Immunol. 2022 Nov 3;13:1001025. doi: 10.3389/fimmu.2022.1001025. eCollection 2022. Front Immunol. 2022. PMID: 36405711 Free PMC article. Review.
S100A9/S100A8 (calprotectin), a member of the S100 protein family, has been shown to play a pivotal role in innate immunity activation. ...Recent studies have demonstrated better correlations between serum or plasma calprotectin and composite inflammatory disease activity …
S100A9/S100A8 (calprotectin), a member of the S100 protein family, has been shown to play a pivotal role in innate immunity activatio …
S100A8/A9 as a biomarker for synovial inflammation and joint damage in patients with rheumatoid arthritis.
Kang KY, Woo JW, Park SH. Kang KY, et al. Korean J Intern Med. 2014 Jan;29(1):12-9. doi: 10.3904/kjim.2014.29.1.12. Epub 2014 Jan 2. Korean J Intern Med. 2014. PMID: 24574827 Free PMC article. Review.
Serum levels of S100A8/A9 are significantly correlated with clinical and laboratory markers of inflammation, such as C-reactive protein, erythrocyte sedimentation rate, rheumatoid factor, and the Disease Activity Score for 28 joints. ...These findings suggest S10 …
Serum levels of S100A8/A9 are significantly correlated with clinical and laboratory markers of inflammation, such as C-reactive prote …
Circulating S100A8/A9 Levels Reflect Intraocular Inflammation in Uveitis Patients.
Wang YQ, Dai XD, Ran Y, Cao Y, Lan CL, Guan JT, Liu C, Yang FM, Gan YJ, Liu BJ, Fang AW, Lin D, Gong XH, Cui RZ, Jin ZB, Qu J, Lu F, Chi ZL. Wang YQ, et al. Ocul Immunol Inflamm. 2020;28(1):133-141. doi: 10.1080/09273948.2018.1538461. Epub 2018 Nov 5. Ocul Immunol Inflamm. 2020. PMID: 30395736
S100A8/A9 plasma levels were also higher in AAU patients with ankylosing spondylitis (AS) than in patients without AS (P = 0.02). S100A8/A9 plasma levels were significantly increased in uveitis patients with elevated C-reactive protein (CRP, P = 0.004) or erythro …
S100A8/A9 plasma levels were also higher in AAU patients with ankylosing spondylitis (AS) than in patients without AS (P = 0.02). …
Calprotectin in rheumatic diseases: a review.
Kopeć-Mędrek M, Widuchowska M, Kucharz EJ. Kopeć-Mędrek M, et al. Reumatologia. 2016;54(6):306-309. doi: 10.5114/reum.2016.64907. Epub 2016 Dec 30. Reumatologia. 2016. PMID: 28115781 Free PMC article. Review.
Calprotectin also known as MRP8/14 or S100A8/A9 is a heterodimeric complex of two S100 calcium-binding proteins: myeloid-related protein 8 (MRP-8 or S100A8) and MRP-14 (or S100A9). At present, according to many authors, it is considered that calprotectin MRP8/14 is …
Calprotectin also known as MRP8/14 or S100A8/A9 is a heterodimeric complex of two S100 calcium-binding proteins: myeloid-related prot …
Efficacy and Safety of Tofacitinib in Patients with Polymyalgia Rheumatica (EAST PMR): An open-label randomized controlled trial.
Ma X, Yang F, Wu J, Xu B, Jiang M, Sun Y, Sun C, Yu Y, Xu D, Xiao L, Ren C, Chen C, Ye Z, Liang J, Lin J, Chen W. Ma X, et al. PLoS Med. 2023 Jun 29;20(6):e1004249. doi: 10.1371/journal.pmed.1004249. eCollection 2023 Jun. PLoS Med. 2023. PMID: 37384596 Free PMC article. Clinical Trial.
We observed marked increases in expression of IL6R, IL1B, IL1R1, JAK2, TLR2, TLR4, TLR8, CCR1, CR1, S100A8, S100A12, and IL17RA, which could trigger JAK signaling. Furthermore, tofacitinib suppressed the IL-6R and JAK2 expression of CD4+T cells from patients with PMR in vi …
We observed marked increases in expression of IL6R, IL1B, IL1R1, JAK2, TLR2, TLR4, TLR8, CCR1, CR1, S100A8, S100A12, and IL17RA, whic …
Calprotectin (S100A8/S100A9) detects inflammatory activity in rheumatoid arthritis patients receiving tocilizumab therapy.
Gernert M, Schmalzing M, Tony HP, Strunz PP, Schwaneck EC, Fröhlich M. Gernert M, et al. Arthritis Res Ther. 2022 Aug 19;24(1):200. doi: 10.1186/s13075-022-02887-7. Arthritis Res Ther. 2022. PMID: 35986420 Free PMC article.
BACKGROUND: Assessing serological inflammation is difficult in tocilizumab (TCZ)-treated rheumatoid arthritis (RA) patients, as standard inflammation parameters, like erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP), are influenced by interleukin-6-recepto …
BACKGROUND: Assessing serological inflammation is difficult in tocilizumab (TCZ)-treated rheumatoid arthritis (RA) patients, as standard inf …
Alarmins S100A8/S100A9 aggravate osteophyte formation in experimental osteoarthritis and predict osteophyte progression in early human symptomatic osteoarthritis.
Schelbergen RF, de Munter W, van den Bosch MH, Lafeber FP, Sloetjes A, Vogl T, Roth J, van den Berg WB, van der Kraan PM, Blom AB, van Lent PL. Schelbergen RF, et al. Ann Rheum Dis. 2016 Jan;75(1):218-25. doi: 10.1136/annrheumdis-2014-205480. Epub 2014 Sep 1. Ann Rheum Dis. 2016. PMID: 25180294
In the current study, we investigated whether S100A8 and S100A9 are involved in osteophyte formation during experimental OA and whether S100A8/A9 predicts osteophyte progression in early human OA. ...Interestingly, early symptomatic OA participants of the CHECK stud …
In the current study, we investigated whether S100A8 and S100A9 are involved in osteophyte formation during experimental OA and wheth …
S100A8-targeting siRNA enhances arsenic trioxide-induced myeloid leukemia cell death by down-regulating autophagy.
Yang L, Yang M, Zhang H, Wang Z, Yu Y, Xie M, Zhao M, Liu L, Cao L. Yang L, et al. Int J Mol Med. 2012 Jan;29(1):65-72. doi: 10.3892/ijmm.2011.806. Epub 2011 Oct 3. Int J Mol Med. 2012. PMID: 21971985
Here we showed that the member of the S100 calcium-binding protein family, S100A8, is a critical regulator of chemoresistance in the autophagy process. ...Furthermore, stimuli that enhanced reactive oxygen species (ROS) promoted cytosolic translocation of S100A8 and …
Here we showed that the member of the S100 calcium-binding protein family, S100A8, is a critical regulator of chemoresistance in the …
Changes in transcriptome of macrophages in atherosclerosis.
Chistiakov DA, Bobryshev YV, Orekhov AN. Chistiakov DA, et al. J Cell Mol Med. 2015 Jun;19(6):1163-73. doi: 10.1111/jcmm.12591. Epub 2015 May 13. J Cell Mol Med. 2015. PMID: 25973901 Free PMC article. Review.
Compared to M0 macrophages, M4 cells have a unique transcriptome, with expression of surface markers such as S100A8, mannose receptor CD206 and matrix metalloproteinase 7. M4 macrophages did not express CD163, a scavenger receptor for haemoglobin/haptoglobin complex. ...Th …
Compared to M0 macrophages, M4 cells have a unique transcriptome, with expression of surface markers such as S100A8, mannose receptor …
Serum S100A8/A9, but not follistatin-like protein 1 and interleukin 18, may be a useful biomarker of disease activity in adult-onset Still's disease.
Kim HA, An JM, Nam JY, Jeon JY, Suh CH. Kim HA, et al. J Rheumatol. 2012 Jul;39(7):1399-406. doi: 10.3899/jrheum.120079. Epub 2012 Jun 1. J Rheumatol. 2012. PMID: 22660800
The sensitivity and specificity of IL-18 for diagnosing AOSD was highest with a cutoff value of 366.1 pg/ml. Serum S100A8/A9 correlated with leukocyte count, erythrocyte sedimentation rate, C-reactive protein, ferritin, and systemic disease score; however, IL-18 cor …
The sensitivity and specificity of IL-18 for diagnosing AOSD was highest with a cutoff value of 366.1 pg/ml. Serum S100A8/A9 correlat …
32 results