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Items: 1 to 20 of 31

1.

Evaluation of the time-dependent antiproliferative activity and liver microsome stability of 3 phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as promising CYP1A1-dependent antimicrotubule prodrugs.

Zarifi Khosroshahi M, Corin Chavez Alvarez A, Gagné-Boulet M, C-Gaudreault R, Gobeil S, Fortin S.

J Pharm Pharmacol. 2020 Feb;72(2):249-258. doi: 10.1111/jphp.13198. Epub 2019 Nov 14.

PMID:
31729035
2.

Stereoselective Synthesis of Fluorinated Galactopyranosides as Potential Molecular Probes for Galactophilic Proteins: Assessment of Monofluorogalactoside-LecA Interactions.

Denavit V, Lainé D, Bouzriba C, Shanina E, Gillon É, Fortin S, Rademacher C, Imberty A, Giguère D.

Chemistry. 2019 Mar 21;25(17):4478-4490. doi: 10.1002/chem.201806197. Epub 2019 Feb 27.

PMID:
30690814
3.

4-(3-Alkyl-2-oxoimidazolidin-1-yl)-N-phenylbenzenesulfonamides as new antimitotic prodrugs activated by cytochrome P450 1A1 in breast cancer cells.

Chavez Alvarez AC, Zarifi Khosroshahi M, Côté MF, Gagné-Boulet M, Fortin S.

Bioorg Med Chem. 2018 Oct 1;26(18):5045-5052. doi: 10.1016/j.bmc.2018.09.001. Epub 2018 Sep 4.

PMID:
30201525
4.

Preparation, characterisation and biological evaluation of new N-phenyl amidobenzenesulfonates and N-phenyl ureidobenzenesulfonates inducing DNA double-strand breaks. Part 3. Modulation of ring A.

Gagné-Boulet M, Bouzriba C, Godard M, Fortin S.

Eur J Med Chem. 2018 Jul 15;155:681-694. doi: 10.1016/j.ejmech.2018.06.030. Epub 2018 Jun 21.

PMID:
29936355
5.

Diversity-Oriented Synthesis of Diol-Based Peptidomimetics as Potential HIV Protease Inhibitors and Antitumor Agents.

Vadhadiya PM, Jean MA, Bouzriba C, Tremblay T, Lagüe P, Fortin S, Boukouvalas J, Giguère D.

Chembiochem. 2018 Jun 2. doi: 10.1002/cbic.201800247. [Epub ahead of print]

PMID:
29858881
6.

Effectiveness of adjuvant carboplatin-based chemotherapy compared to cisplatin in non-small cell lung cancer.

Couillard-Montminy V, Gagnon PY, Fortin S, Côté J.

J Oncol Pharm Pract. 2019 Jan;25(1):44-51. doi: 10.1177/1078155217724595. Epub 2017 Aug 21.

PMID:
28825377
7.

Activation of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates Prodrugs by CYP1A1 as New Antimitotics Targeting Breast Cancer Cells.

Fortin S, Charest-Morin X, Turcotte V, Lauvaux C, Lacroix J, Côté MF, Gobeil S, C-Gaudreault R.

J Med Chem. 2017 Jun 22;60(12):4963-4982. doi: 10.1021/acs.jmedchem.7b00343. Epub 2017 Jun 1.

PMID:
28535350
8.

Investigation of the DNA damage response to SFOM-0046, a new small-molecule drug inducing DNA double-strand breaks.

Pauty J, Côté MF, Rodrigue A, Velic D, Masson JY, Fortin S.

Sci Rep. 2016 Mar 22;6:23302. doi: 10.1038/srep23302.

9.

Synthesis and biological evaluation of novel N-phenyl ureidobenzenesulfonate derivatives as potential anticancer agents. Part 2. Modulation of the ring B.

Gagné-Boulet M, Moussa H, Lacroix J, Côté MF, Masson JY, Fortin S.

Eur J Med Chem. 2015 Oct 20;103:563-73. doi: 10.1016/j.ejmech.2015.09.012. Epub 2015 Sep 10.

PMID:
26408815
10.

Styryl-N-phenyl-N'-(2-chloroethyl)ureas and styrylphenylimidazolidin-2-ones as new potent microtubule-disrupting agents using combretastatin A-4 as model.

Gagné-Boulet M, Fortin S, Lacroix J, Lefebvre CA, Côté MF, C-Gaudreault R.

Eur J Med Chem. 2015 Jul 15;100:34-43. doi: 10.1016/j.ejmech.2015.05.034. Epub 2015 May 28.

PMID:
26069928
11.

New testosterone derivatives as semi-synthetic anticancer agents against prostate cancer: synthesis and preliminary biological evaluation.

Morin N, Bruneau J, Fortin S, Brasseur K, Leblanc V, Asselin E, Berube G.

Med Chem. 2015;11(6):531-9.

PMID:
25675439
12.

New platinum(II) complexes conjugated at position 7α of 17β-acetyl-testosterone as new combi-molecules against prostate cancer: design, synthesis, structure-activity relationships and biological evaluation.

Fortin S, Brasseur K, Morin N, Asselin É, Bérubé G.

Eur J Med Chem. 2013 Oct;68:433-43. doi: 10.1016/j.ejmech.2013.08.011. Epub 2013 Aug 15.

PMID:
23994871
13.

Advances in the development of hybrid anticancer drugs.

Fortin S, Bérubé G.

Expert Opin Drug Discov. 2013 Aug;8(8):1029-47. doi: 10.1517/17460441.2013.798296. Epub 2013 May 7. Review.

PMID:
23646979
14.

Inhibitory effects of cytoskeleton disrupting drugs and GDP-locked Rab mutants on bradykinin B₂ receptor cycling.

Charest-Morin X, Fortin S, Lodge R, Roy C, Gera L, Gaudreault RC, Marceau F.

Pharmacol Res. 2013 May;71:44-52. doi: 10.1016/j.phrs.2013.02.007. Epub 2013 Feb 27.

15.

Design, synthesis, cytocidal activity and estrogen receptor α affinity of doxorubicin conjugates at 16α-position of estrogen for site-specific treatment of estrogen receptor positive breast cancer.

Saha P, Fortin S, Leblanc V, Parent S, Asselin É, Bérubé G.

Steroids. 2012 Sep;77(11):1113-22. doi: 10.1016/j.steroids.2012.06.004. Epub 2012 Jul 16.

PMID:
22801351
16.

Synthesis, biological evaluation, and structure-activity relationships of novel substituted N-phenyl ureidobenzenesulfonate derivatives blocking cell cycle progression in S-phase and inducing DNA double-strand breaks.

Turcotte V, Fortin S, Vevey F, Coulombe Y, Lacroix J, Côté MF, Masson JY, C-Gaudreault R.

J Med Chem. 2012 Jul 12;55(13):6194-208. doi: 10.1021/jm3006492. Epub 2012 Jun 21.

17.

Synthesis, antiproliferative activity and estrogen receptor α affinity of novel estradiol-linked platinum(II) complex analogs to carboplatin and oxaliplatin. Potential vector complexes to target estrogen-dependent tissues.

Saha P, Descôteaux C, Brasseur K, Fortin S, Leblanc V, Parent S, Asselin E, Bérubé G.

Eur J Med Chem. 2012 Feb;48:385-90. doi: 10.1016/j.ejmech.2011.12.017. Epub 2011 Dec 17.

PMID:
22209414
18.

Substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonamides as antimitotics. Antiproliferative, antiangiogenic and antitumoral activity, and quantitative structure-activity relationships.

Fortin S, Wei L, Moreau E, Lacroix J, Côté MF, Petitclerc E, Kotra LP, Gaudreault RC.

Eur J Med Chem. 2011 Nov;46(11):5327-42. doi: 10.1016/j.ejmech.2011.08.034. Epub 2011 Aug 30.

PMID:
21920638
19.

Design, synthesis, biological evaluation, and structure-activity relationships of substituted phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new tubulin inhibitors mimicking combretastatin A-4.

Fortin S, Wei L, Moreau E, Lacroix J, Côté MF, Petitclerc E, Kotra LP, C-Gaudreault R.

J Med Chem. 2011 Jul 14;54(13):4559-80. doi: 10.1021/jm200488a. Epub 2011 Jun 13.

20.

Intramolecular cyclization of N-phenyl N'(2-chloroethyl)ureas leads to active N-phenyl-4,5-dihydrooxazol-2-amines alkylating β-tubulin Glu198 and prohibitin Asp40.

Trzeciakiewicz A, Fortin S, Moreau E, C-Gaudreault R, Lacroix J, Chambon C, Communal Y, Chezal JM, Miot-Noirault E, Bouchon B, Degoul F.

Biochem Pharmacol. 2011 May 1;81(9):1116-23. doi: 10.1016/j.bcp.2011.02.014. Epub 2011 Mar 1.

PMID:
21371445

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