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Items: 1 to 20 of 124


APEX2-enhanced electron microscopy distinguishes sigma-1 receptor localization in the nucleoplasmic reticulum.

Mavlyutov TA, Yang H, Epstein ML, Ruoho AE, Yang J, Guo LW.

Oncotarget. 2017 May 16;8(31):51317-51330. doi: 10.18632/oncotarget.17906. eCollection 2017 Aug 1.


Visualizing Nerve Injury in a Neuropathic Pain Model with [18F]FTC-146 PET/MRI.

Shen B, Behera D, James ML, Reyes ST, Andrews L, Cipriano PW, Klukinov M, Lutz AB, Mavlyutov T, Rosenberg J, Ruoho AE, McCurdy CR, Gambhir SS, Yeomans DC, Biswal S, Chin FT.

Theranostics. 2017 Jul 8;7(11):2794-2805. doi: 10.7150/thno.19378. eCollection 2017.


The Sigma-1 Receptor-A Therapeutic Target for the Treatment of ALS?

Mavlyutov TA, Baker EM, Losenegger TM, Kim JR, Torres B, Epstein ML, Ruoho AE.

Adv Exp Med Biol. 2017;964:255-265. doi: 10.1007/978-3-319-50174-1_17. Review.


Atypical dopamine efflux caused by 3,4-methylenedioxypyrovalerone (MDPV) via the human dopamine transporter.

Shekar A, Aguilar JI, Galli G, Cozzi NV, Brandt SD, Ruoho AE, Baumann MH, Matthies HJG, Galli A.

J Chem Neuroanat. 2017 Oct;83-84:69-74. doi: 10.1016/j.jchemneu.2017.01.004. Epub 2017 Feb 3.


Combined Simulation and Mutation Studies to Elucidate Selectivity of Unsubstituted Amphetamine-like Cathinones at the Dopamine Transporter.

Seddik A, Geerke DP, Stockner T, Holy M, Kudlacek O, Cozzi NV, Ruoho AE, Sitte HH, Ecker GF.

Mol Inform. 2017 May;36(5-6). doi: 10.1002/minf.201600094. Epub 2016 Nov 8.


The Sigma-2 Receptor and Progesterone Receptor Membrane Component 1 are Different Binding Sites Derived From Independent Genes.

Chu UB, Mavlyutov TA, Chu ML, Yang H, Schulman A, Mesangeau C, McCurdy CR, Guo LW, Ruoho AE.

EBioMedicine. 2015 Oct 19;2(11):1806-13. doi: 10.1016/j.ebiom.2015.10.017. eCollection 2015 Nov.


Sigma Receptor Binding Assays.

Chu UB, Ruoho AE.

Curr Protoc Pharmacol. 2015 Dec 8;71:1.34.1-21. doi: 10.1002/0471141755.ph0134s71.


Biochemical Pharmacology of the Sigma-1 Receptor.

Chu UB, Ruoho AE.

Mol Pharmacol. 2016 Jan;89(1):142-53. doi: 10.1124/mol.115.101170. Epub 2015 Nov 11. Review.


Role of the Sigma-1 receptor in Amyotrophic Lateral Sclerosis (ALS).

Mavlyutov TA, Guo LW, Epstein ML, Ruoho AE.

J Pharmacol Sci. 2015 Jan;127(1):10-6. doi: 10.1016/j.jphs.2014.12.013. Epub 2015 Jan 5. Review.


The oligomeric states of the purified sigma-1 receptor are stabilized by ligands.

Gromek KA, Suchy FP, Meddaugh HR, Wrobel RL, LaPointe LM, Chu UB, Primm JG, Ruoho AE, Senes A, Fox BG.

J Biol Chem. 2014 Jul 18;289(29):20333-44. doi: 10.1074/jbc.M113.537993. Epub 2014 May 20.


Noncompetitive inhibition of indolethylamine-N-methyltransferase by N,N-dimethyltryptamine and N,N-dimethylaminopropyltryptamine.

Chu UB, Vorperian SK, Satyshur K, Eickstaedt K, Cozzi NV, Mavlyutov T, Hajipour AR, Ruoho AE.

Biochemistry. 2014 May 13;53(18):2956-65. doi: 10.1021/bi500175p. Epub 2014 Apr 28.


N-terminus regulation of VMAT2 mediates methamphetamine-stimulated efflux.

Torres B, Ruoho AE.

Neuroscience. 2014 Feb 14;259:194-202. doi: 10.1016/j.neuroscience.2013.11.059. Epub 2013 Dec 7.


Lack of sigma-1 receptor exacerbates ALS progression in mice.

Mavlyutov TA, Epstein ML, Verbny YI, Huerta MS, Zaitoun I, Ziskind-Conhaim L, Ruoho AE.

Neuroscience. 2013 Jun 14;240:129-34. doi: 10.1016/j.neuroscience.2013.02.035. Epub 2013 Feb 28.


Photoaffinity labeling of the sigma-1 receptor with N-[3-(4-nitrophenyl)propyl]-N-dodecylamine: evidence of receptor dimers.

Chu UB, Ramachandran S, Hajipour AR, Ruoho AE.

Biochemistry. 2013 Feb 5;52(5):859-68. doi: 10.1021/bi301517u. Epub 2013 Jan 28.


Development of benzophenone-alkyne bifunctional sigma receptor ligands.

Guo LW, Hajipour AR, Karaoglu K, Mavlyutov TA, Ruoho AE.

Chembiochem. 2012 Oct 15;13(15):2277-89. doi: 10.1002/cbic.201200427. Epub 2012 Sep 23.


The sigma-1 receptor protects against cellular oxidative stress and activates antioxidant response elements.

Pal A, Fontanilla D, Gopalakrishnan A, Chae YK, Markley JL, Ruoho AE.

Eur J Pharmacol. 2012 May 5;682(1-3):12-20. doi: 10.1016/j.ejphar.2012.01.030. Epub 2012 Feb 22.


The ligand binding region of the sigma-1 receptor: studies utilizing photoaffinity probes, sphingosine and N-alkylamines.

Ruoho AE, Chu UB, Ramachandran S, Fontanilla D, Mavlyutov T, Hajipour AR.

Curr Pharm Des. 2012;18(7):920-9. Review.


Development of the sigma-1 receptor in C-terminals of motoneurons and colocalization with the N,N'-dimethyltryptamine forming enzyme, indole-N-methyl transferase.

Mavlyutov TA, Epstein ML, Liu P, Verbny YI, Ziskind-Conhaim L, Ruoho AE.

Neuroscience. 2012 Mar 29;206:60-8. doi: 10.1016/j.neuroscience.2011.12.040. Epub 2012 Jan 4.


The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue.

Baumann MH, Ayestas MA Jr, Partilla JS, Sink JR, Shulgin AT, Daley PF, Brandt SD, Rothman RB, Ruoho AE, Cozzi NV.

Neuropsychopharmacology. 2012 Apr;37(5):1192-203. doi: 10.1038/npp.2011.304. Epub 2011 Dec 14.


Electron-donating para-methoxy converts a benzamide-isoquinoline derivative into a highly Sigma-2 receptor selective ligand.

Hajipour AR, Guo LW, Pal A, Mavlyutov T, Ruoho AE.

Bioorg Med Chem. 2011 Dec 15;19(24):7435-40. doi: 10.1016/j.bmc.2011.10.046. Epub 2011 Oct 20.

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