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Items: 1 to 20 of 40

1.

Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro.

Carr BJ, Mihara K, Ramachandran R, Saifeddine M, Nathanson NM, Stell WK, Hollenberg MD.

Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2778-2791. doi: 10.1167/iovs.17-22562.

PMID:
29860464
2.

Shear stress sensitizes TRPV4 in endothelium-dependent vasodilatation.

Darby WG, Potocnik S, Ramachandran R, Hollenberg MD, Woodman OL, McIntyre P.

Pharmacol Res. 2018 Jul;133:152-159. doi: 10.1016/j.phrs.2018.05.009. Epub 2018 May 19.

PMID:
29787869
3.

The cooling compound icilin attenuates autoimmune neuroinflammation through modulation of the T-cell response.

Ewanchuk BW, Allan ERO, Warren AL, Ramachandran R, Yates RM.

FASEB J. 2018 Mar;32(3):1236-1249. doi: 10.1096/fj.201700552R. Epub 2018 Jan 3.

PMID:
29114087
4.

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.

Alexander SP, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators.

Br J Pharmacol. 2017 Dec;174 Suppl 1:S1-S16. doi: 10.1111/bph.13882.

5.

Cockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase-activated receptor-2.

Polley DJ, Mihara K, Ramachandran R, Vliagoftis H, Renaux B, Saifeddine M, Daines MO, Boitano S, Hollenberg MD.

Clin Exp Allergy. 2017 Jul;47(7):946-960. doi: 10.1111/cea.12921. Epub 2017 Apr 27.

6.

Targeting a Proteinase-Activated Receptor 4 (PAR4) Carboxyl Terminal Motif to Regulate Platelet Function.

Ramachandran R, Mihara K, Thibeault P, Vanderboor CM, Petri B, Saifeddine M, Bouvier M, Hollenberg MD.

Mol Pharmacol. 2017 Apr;91(4):287-295. doi: 10.1124/mol.116.106526. Epub 2017 Jan 26.

PMID:
28126849
7.

Proteinases, Their Extracellular Targets, and Inflammatory Signaling.

Ramachandran R, Altier C, Oikonomopoulou K, Hollenberg MD.

Pharmacol Rev. 2016 Oct;68(4):1110-1142. Review.

PMID:
27677721
8.

Natural-Product-Derived Transient Receptor Potential Melastatin 8 (TRPM8) Channel Modulators.

LeGay CM, Gorobets E, Iftinca M, Ramachandran R, Altier C, Derksen DJ.

Org Lett. 2016 Jun 3;18(11):2746-9. doi: 10.1021/acs.orglett.6b01222. Epub 2016 May 12.

PMID:
27171974
9.

Thrombin-Mediated Direct Activation of Proteinase-Activated Receptor-2: Another Target for Thrombin Signaling.

Mihara K, Ramachandran R, Saifeddine M, Hansen KK, Renaux B, Polley D, Gibson S, Vanderboor C, Hollenberg MD.

Mol Pharmacol. 2016 May;89(5):606-14. doi: 10.1124/mol.115.102723. Epub 2016 Mar 8.

PMID:
26957205
10.

Neuroinflammation-Induced Interactions between Protease-Activated Receptor 1 and Proprotein Convertases in HIV-Associated Neurocognitive Disorder.

Kim W, Zekas E, Lodge R, Susan-Resiga D, Marcinkiewicz E, Essalmani R, Mihara K, Ramachandran R, Asahchop E, Gelman B, Cohen ÉA, Power C, Hollenberg MD, Seidah NG.

Mol Cell Biol. 2015 Nov;35(21):3684-700. doi: 10.1128/MCB.00764-15. Epub 2015 Aug 17.

11.

GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature.

Saifeddine M, El-Daly M, Mihara K, Bunnett NW, McIntyre P, Altier C, Hollenberg MD, Ramachandran R.

Br J Pharmacol. 2015 May;172(10):2493-506. doi: 10.1111/bph.13072. Epub 2015 Mar 18.

12.

Proteinase-activated receptor 2 (PAR2) decreases apoptosis in colonic epithelial cells.

Iablokov V, Hirota CL, Peplowski MA, Ramachandran R, Mihara K, Hollenberg MD, MacNaughton WK.

J Biol Chem. 2014 Dec 5;289(49):34366-77. doi: 10.1074/jbc.M114.610485. Epub 2014 Oct 20.

13.

The Concise Guide to PHARMACOLOGY 2013/14: overview.

Alexander SP, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ; CGTP Collaborators, Abul-Hasn N, Anderson CM, Anderson CM, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJ, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P, Calo G, Carter WG, Catterall WA, Chan SL, Chao MV, Chiang N, Christopoulos A, Chun JJ, Cidlowski J, Clapham DE, Cockcroft S, Connor MA, Cox HM, Cuthbert A, Dautzenberg FM, Davenport AP, Dawson PA, Dent G, Dijksterhuis JP, Dollery CT, Dolphin AC, Donowitz M, Dubocovich ML, Eiden L, Eidne K, Evans BA, Fabbro D, Fahlke C, Farndale R, Fitzgerald GA, Fong TM, Fowler CJ, Fry JR, Funk CD, Futerman AH, Ganapathy V, Gaisnier B, Gershengorn MA, Goldin A, Goldman ID, Gundlach AL, Hagenbuch B, Hales TG, Hammond JR, Hamon M, Hancox JC, Hauger RL, Hay DL, Hobbs AJ, Hollenberg MD, Holliday ND, Hoyer D, Hynes NA, Inui KI, Ishii S, Jacobson KA, Jarvis GE, Jarvis MF, Jensen R, Jones CE, Jones RL, Kaibuchi K, Kanai Y, Kennedy C, Kerr ID, Khan AA, Klienz MJ, Kukkonen JP, Lapoint JY, Leurs R, Lingueglia E, Lippiat J, Lolait SJ, Lummis SC, Lynch JW, MacEwan D, Maguire JJ, Marshall IL, May JM, McArdle CA, McGrath JC, Michel MC, Millar NS, Miller LJ, Mitolo V, Monk PN, Moore PK, Moorhouse AJ, Mouillac B, Murphy PM, Neubig RR, Neumaier J, Niesler B, Obaidat A, Offermanns S, Ohlstein E, Panaro MA, Parsons S, Pwrtwee RG, Petersen J, Pin JP, Poyner DR, Prigent S, Prossnitz ER, Pyne NJ, Pyne S, Quigley JG, Ramachandran R, Richelson EL, Roberts RE, Roskoski R, Ross RA, Roth M, Rudnick G, Ryan RM, Said SI, Schild L, Sanger GJ, Scholich K, Schousboe A, Schulte G, Schulz S, Serhan CN, Sexton PM, Sibley DR, Siegel JM, Singh G, Sitsapesan R, Smart TG, Smith DM, Soga T, Stahl A, Stewart G, Stoddart LA, Summers RJ, Thorens B, Thwaites DT, Toll L, Traynor JR, Usdin TB, Vandenberg RJ, Villalon C, Vore M, Waldman SA, Ward DT, Willars GB, Wonnacott SJ, Wright E, Ye RD, Yonezawa A, Zimmermann M.

Br J Pharmacol. 2013 Dec;170(8):1449-58. doi: 10.1111/bph.12444.

14.

Proteinase-activated receptors 1 and 2 and the regulation of porcine coronary artery contractility: a role for distinct tyrosine kinase pathways.

El-Daly M, Saifeddine M, Mihara K, Ramachandran R, Triggle CR, Hollenberg MD.

Br J Pharmacol. 2014 May;171(9):2413-25. doi: 10.1111/bph.12593.

15.

Biased signalling and proteinase-activated receptors (PARs): targeting inflammatory disease.

Hollenberg MD, Mihara K, Polley D, Suen JY, Han A, Fairlie DP, Ramachandran R.

Br J Pharmacol. 2014 Mar;171(5):1180-94. doi: 10.1111/bph.12544. Review.

16.

Proteinase-activated receptor-2 transactivation of epidermal growth factor receptor and transforming growth factor-β receptor signaling pathways contributes to renal fibrosis.

Chung H, Ramachandran R, Hollenberg MD, Muruve DA.

J Biol Chem. 2013 Dec 27;288(52):37319-31. doi: 10.1074/jbc.M113.492793. Epub 2013 Nov 19.

17.

Implantation serine proteinase 2 is a monomeric enzyme with mixed serine proteolytic activity and can silence signalling via proteinase activated receptors.

Sharma N, Fahr J, Renaux B, Saifeddine M, Kumar R, Nishikawa S, Mihara K, Ramachandran R, Hollenberg MD, Rancourt DE.

Biochem Cell Biol. 2013 Dec;91(6):487-97. doi: 10.1139/bcb-2013-0006. Epub 2013 Aug 6.

PMID:
24219291
18.

Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).

Mihara K, Ramachandran R, Renaux B, Saifeddine M, Hollenberg MD.

J Biol Chem. 2013 Nov 15;288(46):32979-90. doi: 10.1074/jbc.M113.483123. Epub 2013 Sep 19.

19.

TRPM8 activation attenuates inflammatory responses in mouse models of colitis.

Ramachandran R, Hyun E, Zhao L, Lapointe TK, Chapman K, Hirota CL, Ghosh S, McKemy DD, Vergnolle N, Beck PL, Altier C, Hollenberg MD.

Proc Natl Acad Sci U S A. 2013 Apr 30;110(18):7476-81. doi: 10.1073/pnas.1217431110. Epub 2013 Apr 17.

20.

Developing PAR1 antagonists: minding the endothelial gap.

Ramachandran R.

Discov Med. 2012 Jun;13(73):425-31. Review.

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