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Sci Rep. 2018 Mar 15;8(1):4165. doi: 10.1038/s41598-018-22437-z.

Detecting and classifying lesions in mammograms with Deep Learning.

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Department of Physics of Complex Systems, Eötvös Loránd University, Budapest, Hungary.
3rd Department of Internal Medicine, Semmelweis University, Budapest, Hungary.
Department of Radiology, Semmelweis University, Budapest, Hungary.
MTA-ELTE Statistical and Biological Physics Research Group, Hungarian Academy of Sciences, Budapest, Hungary.
Department of Physics of Complex Systems, Eötvös Loránd University, Budapest, Hungary.


In the last two decades, Computer Aided Detection (CAD) systems were developed to help radiologists analyse screening mammograms, however benefits of current CAD technologies appear to be contradictory, therefore they should be improved to be ultimately considered useful. Since 2012, deep convolutional neural networks (CNN) have been a tremendous success in image recognition, reaching human performance. These methods have greatly surpassed the traditional approaches, which are similar to currently used CAD solutions. Deep CNN-s have the potential to revolutionize medical image analysis. We propose a CAD system based on one of the most successful object detection frameworks, Faster R-CNN. The system detects and classifies malignant or benign lesions on a mammogram without any human intervention. The proposed method sets the state of the art classification performance on the public INbreast database, AUC = 0.95. The approach described here has achieved 2nd place in the Digital Mammography DREAM Challenge with AUC = 0.85. When used as a detector, the system reaches high sensitivity with very few false positive marks per image on the INbreast dataset. Source code, the trained model and an OsiriX plugin are published online at .

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