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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1879 1
1880 1
1901 1
1909 1
1914 1
1915 1
1916 1
1924 3
1933 2
1937 1
1938 2
1939 2
1943 1
1944 1
1945 3
1946 8
1947 4
1948 11
1949 9
1950 23
1951 20
1952 20
1953 34
1954 28
1955 34
1956 32
1957 46
1958 29
1959 49
1960 42
1961 55
1962 54
1963 88
1964 122
1965 165
1966 178
1967 242
1968 304
1969 421
1970 443
1971 602
1972 700
1973 694
1974 740
1975 824
1976 790
1977 807
1978 887
1979 904
1980 935
1981 1062
1982 1197
1983 1125
1984 1231
1985 1334
1986 1322
1987 1389
1988 1426
1989 1607
1990 1667
1991 1687
1992 1841
1993 1812
1994 1947
1995 1951
1996 2084
1997 2042
1998 2291
1999 2330
2000 2508
2001 2489
2002 2548
2003 2682
2004 2718
2005 2938
2006 3024
2007 3219
2008 3310
2009 3358
2010 3534
2011 3777
2012 4148
2013 4190
2014 4426
2015 4516
2016 4670
2017 4799
2018 4859
2019 4792
2020 5574
2021 5641
2022 5268
2023 4926
2024 2234
2025 3

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128,136 results

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Page 1
eIF2alpha incites photoreceptor cell and retina damage by all-trans-retinal.
He D, Tao L, Cai B, Chen X, Wang Y, Li S, Liao C, Chen Y, Chen J, Liu Z, Wu Y. He D, et al. J Biol Chem. 2023 May;299(5):104686. doi: 10.1016/j.jbc.2023.104686. Epub 2023 Apr 7. J Biol Chem. 2023. PMID: 37031820 Free PMC article.
Dry age-related macular degeneration (AMD) and recessive Stargardt's disease (STGD1) lead to irreversible blindness in humans. The accumulation of all-trans-retinal (atRAL) induced by chaos in visual cycle is closely associated with retinal atrophy in dry AMD and ST …
Dry age-related macular degeneration (AMD) and recessive Stargardt's disease (STGD1) lead to irreversible blindness in humans. The accumulat …
Interplay between Muller cells and microglia aggravates retinal inflammatory response in experimental glaucoma.
Hu X, Zhao GL, Xu MX, Zhou H, Li F, Miao Y, Lei B, Yang XL, Wang Z. Hu X, et al. J Neuroinflammation. 2021 Dec 24;18(1):303. doi: 10.1186/s12974-021-02366-x. J Neuroinflammation. 2021. PMID: 34952606 Free PMC article.
BACKGROUND: Glaucoma, the leading cause of irreversible blindness, is a retinal neurodegenerative disease, which results from progressive apoptotic death of retinal ganglion cells (RGCs). Although the mechanisms underlying RGC apoptosis in glaucoma are extrem …
BACKGROUND: Glaucoma, the leading cause of irreversible blindness, is a retinal neurodegenerative disease, which results from progres …
Retinal phototransduction.
Mannu GS. Mannu GS. Neurosciences (Riyadh). 2014 Oct;19(4):275-80. Neurosciences (Riyadh). 2014. PMID: 25274585 Free PMC article. Review.
Vision is perhaps the most important of all our senses, and gives us an immense amount of information regarding the outside world. The initial format in which this information reaches the retina are photons; particles of energy radiation of a given wavelength emitted or re …
Vision is perhaps the most important of all our senses, and gives us an immense amount of information regarding the outside world. The initi …
Transcriptome-based molecular staging of human stem cell-derived retinal organoids uncovers accelerated photoreceptor differentiation by 9-cis retinal.
Kaya KD, Chen HY, Brooks MJ, Kelley RA, Shimada H, Nagashima K, de Val N, Drinnan CT, Gieser L, Kruczek K, Erceg S, Li T, Lukovic D, Adlakha YK, Welby E, Swaroop A. Kaya KD, et al. Mol Vis. 2019 Nov 11;25:663-678. eCollection 2019. Mol Vis. 2019. PMID: 31814692 Free PMC article.
PURPOSE: Retinal organoids generated from human pluripotent stem cells exhibit considerable variability during differentiation. ...METHODS: We performed transcriptome analyses of developing retinal organoids from human embryonic and induced pluripotent stem …
PURPOSE: Retinal organoids generated from human pluripotent stem cells exhibit considerable variability during differentiation …
Retinal photodamage mediated by all-trans-retinal.
Maeda T, Golczak M, Maeda A. Maeda T, et al. Photochem Photobiol. 2012 Nov-Dec;88(6):1309-19. doi: 10.1111/j.1751-1097.2012.01143.x. Epub 2012 Apr 24. Photochem Photobiol. 2012. PMID: 22428905 Free PMC article. Review.
This photodamage is characterized by progressive retinal cell death evoked by light exposure in both an acute and chronic fashion. ...Herein, we discuss the mechanisms of all-trans-RAL clearance in photoreceptor cells by sequential enzymatic reactions, the vi …
This photodamage is characterized by progressive retinal cell death evoked by light exposure in both an acute and chronic fash …
Human retinal and brain cell lines: A model of HCMV retinitis and encephalitis.
Dutt K, Ezeonu I. Dutt K, et al. DNA Cell Biol. 2006 Oct;25(10):581-96. doi: 10.1089/dna.2006.25.581. DNA Cell Biol. 2006. PMID: 17132089
We report that both human retinal and brain cell lines are permissive for HCMV infectibility. Cell specificity was not seen; both cells expressing glial/neuronal cell markers were positive for the presence of HCMV early/late antigens. ...
We report that both human retinal and brain cell lines are permissive for HCMV infectibility. Cell specificity was not …
Microglia-Muller cell interactions in the retina.
Wang M, Wong WT. Wang M, et al. Adv Exp Med Biol. 2014;801:333-8. doi: 10.1007/978-1-4614-3209-8_42. Adv Exp Med Biol. 2014. PMID: 24664715 Free PMC article. Review.
Microglia and Muller cells are cell types that feature prominently in responses to disease and injury in the retina. ...Microglia-Muller cell interactions appear to be a mode of bi-directional communications that help shape the overall injury response …
Microglia and Muller cells are cell types that feature prominently in responses to disease and injury in the retina. .. …
Vitamin A and Vision.
Saari JC. Saari JC. Subcell Biochem. 2016;81:231-259. doi: 10.1007/978-94-024-0945-1_9. Subcell Biochem. 2016. PMID: 27830507 Review.
Visual systems detect light by monitoring the effect of photoisomerization of a chromophore on the release of a neurotransmitter from sensory neurons, known as rod and cone photoreceptor cells in vertebrate retina. In all known visual systems, the chromophore is 11- …
Visual systems detect light by monitoring the effect of photoisomerization of a chromophore on the release of a neurotransmitter from sensor …
The peroxisome proliferator-activated receptor-beta/delta antagonist GSK0660 mitigates retinal cell inflammation and leukostasis.
Capozzi ME, Savage SR, McCollum GW, Hammer SS, Ramos CJ, Yang R, Bretz CA, Penn JS. Capozzi ME, et al. Exp Eye Res. 2020 Jan;190:107885. doi: 10.1016/j.exer.2019.107885. Epub 2019 Nov 20. Exp Eye Res. 2020. PMID: 31758977 Free PMC article.
Diabetic retinopathy (DR) is triggered by retinal cell damage stimulated by the diabetic milieu, including increased levels of intraocular free fatty acids. ...To test this, we used the PPARbeta/delta inhibitor, GSK0660, in primary human Muller cells (HMC), h …
Diabetic retinopathy (DR) is triggered by retinal cell damage stimulated by the diabetic milieu, including increased levels of …
Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia.
Tworak A, Kolesnikov AV, Hong JD, Choi EH, Luu JC, Palczewska G, Dong Z, Lewandowski D, Brooks MJ, Campello L, Swaroop A, Kiser PD, Kefalov VJ, Palczewski K. Tworak A, et al. Cell Rep. 2023 Aug 29;42(8):112982. doi: 10.1016/j.celrep.2023.112982. Epub 2023 Aug 15. Cell Rep. 2023. PMID: 37585292 Free PMC article.
In daylight, demand for visual chromophore (11-cis-retinal) exceeds supply by the classical visual cycle. This shortfall is compensated, in part, by the retinal G-protein-coupled receptor (RGR) photoisomerase, which is expressed in both the retinal pigment ep …
In daylight, demand for visual chromophore (11-cis-retinal) exceeds supply by the classical visual cycle. This shortfall is compensat …
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