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J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Nov 15;1068-1069:149-156. doi: 10.1016/j.jchromb.2017.10.002. Epub 2017 Oct 4.

Effects of Pu-erh ripened tea on hyperuricemic mice studied by serum metabolomics.

Author information

1
Tea Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, Guangdong 510640, China; Key Laboratory of Ministry of Education for Tea Science, Hunan Agriculture University, Changsha, Hunan 410128, China; Guangdong Key Laboratory of Tea Plant Resources Innovation and Utilization, Guangzhou, Guangdong 510640, China. Electronic address: 250424005@qq.com.
2
Tea Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, Guangdong 510640, China; Guangdong Key Laboratory of Tea Plant Resources Innovation and Utilization, Guangzhou, Guangdong 510640, China. Electronic address: chendong1113@sohu.com.
3
Tea Research Institute, Guangdong Academy of Agricultural Sciences, Guangzhou, Guangdong 510640, China; Guangdong Key Laboratory of Tea Plant Resources Innovation and Utilization, Guangzhou, Guangdong 510640, China. Electronic address: wuhualing@163.com.

Abstract

To evaluate effects of Pu-erh ripened tea in hyperuricemic mice, a mouse hyperuricemia model was developed by oral administration of potassium oxonate for 7 d. Serum metabolomics, based on gas chromatography-mass spectrometry, was used to generate metabolic profiles from normal control, hyperuricemic and allopurinol-treated hyperuricemic mice, as well as hyperuricemic mice given Pu-erh ripened tea at three doses. Pu-erh ripened tea significantly lowered serum uric acid levels. Twelve potential biomarkers associated with hyperuricemia were identified. Pu-erh ripened tea and allopurinol differed in their metabolic effects in the hyperuricemic mice. Levels of glutamic acid, indolelactate, L-allothreonine, nicotinoylglycine, isoleucine, l-cysteine and glycocyamine, all involved in amino acid metabolism, were significantly changed in hyperuricemic mice treated Pu-erh ripened tea. Thus, modulating amino acid metabolism might be the primary mechanism of anti-hyperuricemia by Pu-erh ripened tea.

KEYWORDS:

GC–MS; Hyperuricemia; Metabolomics; Pu-erh ripened tea

PMID:
29069630
DOI:
10.1016/j.jchromb.2017.10.002
[Indexed for MEDLINE]

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