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Items: 1 to 20 of 167

1.

Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease.

Pettinati I, Grzechnik P, Ribeiro de Almeida C, Brem J, McDonough MA, Dhir S, Proudfoot NJ, Schofield CJ.

Elife. 2018 Dec 3;7. pii: e39865. doi: 10.7554/eLife.39865.

2.

R-loop formation during S phase is restricted by PrimPol-mediated repriming.

Šviković S, Crisp A, Tan-Wong SM, Guilliam TA, Doherty AJ, Proudfoot NJ, Guilbaud G, Sale JE.

EMBO J. 2019 Feb 1;38(3). pii: e99793. doi: 10.15252/embj.201899793. Epub 2018 Nov 26.

3.

Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence.

Nojima T, Tellier M, Foxwell J, Ribeiro de Almeida C, Tan-Wong SM, Dhir S, Dujardin G, Dhir A, Murphy S, Proudfoot NJ.

Mol Cell. 2018 Dec 20;72(6):970-984.e7. doi: 10.1016/j.molcel.2018.10.011. Epub 2018 Nov 15.

4.

RNA Polymerase II Phosphorylated on CTD Serine 5 Interacts with the Spliceosome during Co-transcriptional Splicing.

Nojima T, Rebelo K, Gomes T, Grosso AR, Proudfoot NJ, Carmo-Fonseca M.

Mol Cell. 2018 Oct 18;72(2):369-379.e4. doi: 10.1016/j.molcel.2018.09.004.

5.

Mitochondrial double-stranded RNA triggers antiviral signalling in humans.

Dhir A, Dhir S, Borowski LS, Jimenez L, Teitell M, Rötig A, Crow YJ, Rice GI, Duffy D, Tamby C, Nojima T, Munnich A, Schiff M, de Almeida CR, Rehwinkel J, Dziembowski A, Szczesny RJ, Proudfoot NJ.

Nature. 2018 Aug;560(7717):238-242. doi: 10.1038/s41586-018-0363-0. Epub 2018 Jul 25.

PMID:
30046113
6.

Influenza Virus Mounts a Two-Pronged Attack on Host RNA Polymerase II Transcription.

Bauer DLV, Tellier M, Martínez-Alonso M, Nojima T, Proudfoot NJ, Murphy S, Fodor E.

Cell Rep. 2018 May 15;23(7):2119-2129.e3. doi: 10.1016/j.celrep.2018.04.047.

7.

RNA Helicase DDX1 Converts RNA G-Quadruplex Structures into R-Loops to Promote IgH Class Switch Recombination.

Ribeiro de Almeida C, Dhir S, Dhir A, Moghaddam AE, Sattentau Q, Meinhart A, Proudfoot NJ.

Mol Cell. 2018 May 17;70(4):650-662.e8. doi: 10.1016/j.molcel.2018.04.001. Epub 2018 May 3.

8.

Nuclear fate of yeast snoRNA is determined by co-transcriptional Rnt1 cleavage.

Grzechnik P, Szczepaniak SA, Dhir S, Pastucha A, Parslow H, Matuszek Z, Mischo HE, Kufel J, Proudfoot NJ.

Nat Commun. 2018 May 3;9(1):1783. doi: 10.1038/s41467-018-04094-y.

9.

WNK1 kinase and the termination factor PCF11 connect nuclear mRNA export with transcription.

Volanakis A, Kamieniarz-Gdula K, Schlackow M, Proudfoot NJ.

Genes Dev. 2017 Nov 1;31(21):2175-2185. doi: 10.1101/gad.303677.117. Epub 2017 Dec 1.

10.

Distinctive Patterns of Transcription and RNA Processing for Human lincRNAs.

Schlackow M, Nojima T, Gomes T, Dhir A, Carmo-Fonseca M, Proudfoot NJ.

Mol Cell. 2017 Jan 5;65(1):25-38. doi: 10.1016/j.molcel.2016.11.029. Epub 2016 Dec 22.

11.

Transcriptional termination in mammals: Stopping the RNA polymerase II juggernaut.

Proudfoot NJ.

Science. 2016 Jun 10;352(6291):aad9926. doi: 10.1126/science.aad9926. Review.

12.

Mammalian NET-seq analysis defines nascent RNA profiles and associated RNA processing genome-wide.

Nojima T, Gomes T, Carmo-Fonseca M, Proudfoot NJ.

Nat Protoc. 2016 Mar;11(3):413-28. doi: 10.1038/nprot.2016.012. Epub 2016 Feb 4.

13.

Transcriptional Termination Enhances Protein Expression in Human Cells.

West S, Proudfoot NJ.

Mol Cell. 2016 Feb 4;61(3):486. doi: 10.1016/j.molcel.2016.01.021. Epub 2016 Feb 4. No abstract available.

14.

Mammalian NET-Seq Reveals Genome-wide Nascent Transcription Coupled to RNA Processing.

Nojima T, Gomes T, Grosso ARF, Kimura H, Dye MJ, Dhir S, Carmo-Fonseca M, Proudfoot NJ.

Cell. 2015 Apr 23;161(3):526-540. doi: 10.1016/j.cell.2015.03.027.

15.

Pcf11 orchestrates transcription termination pathways in yeast.

Grzechnik P, Gdula MR, Proudfoot NJ.

Genes Dev. 2015 Apr 15;29(8):849-61. doi: 10.1101/gad.251470.114. Epub 2015 Apr 15.

16.

Microprocessor mediates transcriptional termination of long noncoding RNA transcripts hosting microRNAs.

Dhir A, Dhir S, Proudfoot NJ, Jopling CL.

Nat Struct Mol Biol. 2015 Apr;22(4):319-27. doi: 10.1038/nsmb.2982. Epub 2015 Mar 2.

17.

BRCA1 recruitment to transcriptional pause sites is required for R-loop-driven DNA damage repair.

Hatchi E, Skourti-Stathaki K, Ventz S, Pinello L, Yen A, Kamieniarz-Gdula K, Dimitrov S, Pathania S, McKinney KM, Eaton ML, Kellis M, Hill SJ, Parmigiani G, Proudfoot NJ, Livingston DM.

Mol Cell. 2015 Feb 19;57(4):636-647. doi: 10.1016/j.molcel.2015.01.011.

18.

R-loops induce repressive chromatin marks over mammalian gene terminators.

Skourti-Stathaki K, Kamieniarz-Gdula K, Proudfoot NJ.

Nature. 2014 Dec 18;516(7531):436-9. doi: 10.1038/nature13787. Epub 2014 Oct 5.

19.

A double-edged sword: R loops as threats to genome integrity and powerful regulators of gene expression.

Skourti-Stathaki K, Proudfoot NJ.

Genes Dev. 2014 Jul 1;28(13):1384-96. doi: 10.1101/gad.242990.114. Review.

20.

Terminate and make a loop: regulation of transcriptional directionality.

Grzechnik P, Tan-Wong SM, Proudfoot NJ.

Trends Biochem Sci. 2014 Jul;39(7):319-27. doi: 10.1016/j.tibs.2014.05.001. Epub 2014 Jun 10. Review.

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