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Year Number of Results
1949 1
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1958 1
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1965 3
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1967 1
1968 1
1969 1
1971 2
1972 2
1973 1
1974 2
1975 4
1976 6
1977 5
1978 5
1979 12
1980 5
1981 6
1982 5
1983 4
1984 8
1985 13
1986 14
1987 13
1988 17
1989 11
1990 17
1991 9
1992 19
1993 22
1994 18
1995 25
1996 25
1997 16
1998 21
1999 24
2000 23
2001 32
2002 26
2003 30
2004 39
2005 47
2006 46
2007 36
2008 48
2009 39
2010 43
2011 53
2012 40
2013 69
2014 69
2015 44
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2023 46
2024 16

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1,263 results

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Page 1
Propylene glycol, skin sensitisation and allergic contact dermatitis: A scientific and regulatory conundrum.
Pemberton MA, Kimber I. Pemberton MA, et al. Regul Toxicol Pharmacol. 2023 Feb;138:105341. doi: 10.1016/j.yrtph.2023.105341. Epub 2023 Jan 23. Regul Toxicol Pharmacol. 2023. PMID: 36702195 Free article. Review.
Propylene glycol (PG) has widespread use in pharmaceuticals, cosmetics, fragrances and personal care products. ...Patch testing in humans points to PG having the potential to be a weak allergen under certain conditions, and an uncommon cause of ACD in subjects witho …
Propylene glycol (PG) has widespread use in pharmaceuticals, cosmetics, fragrances and personal care products. ...Patch testin …
Effect of propylene glycol on the skin penetration of drugs.
Carrer V, Alonso C, Pont M, Zanuy M, Córdoba M, Espinosa S, Barba C, Oliver MA, Martí M, Coderch L. Carrer V, et al. Arch Dermatol Res. 2020 Jul;312(5):337-352. doi: 10.1007/s00403-019-02017-5. Epub 2019 Nov 30. Arch Dermatol Res. 2020. PMID: 31786711
Propylene glycol (PG) has been used in formulations as a co-solvent and/or to enhance drug permeation through the skin from topical preparations. ...The in vitro Skin-PAMPA was performed using 24 actives applied in aqueous buffer or PG. ...
Propylene glycol (PG) has been used in formulations as a co-solvent and/or to enhance drug permeation through the skin …
Skin-sensitizing and irritant properties of propylene glycol.
Lessmann H, Schnuch A, Geier J, Uter W. Lessmann H, et al. Contact Dermatitis. 2005 Nov;53(5):247-59. doi: 10.1111/j.0105-1873.2005.00693.x. Contact Dermatitis. 2005. PMID: 16283903 Review.
In the several publications reviewed in this article, propylene glycol (PG; 1,2-propylene glycol) is described as a very weak contact sensitizer, if at all. ...Therefore, according to our patch test data, PG seems to exhibit very low sensitization pote …
In the several publications reviewed in this article, propylene glycol (PG; 1,2-propylene glycol) is described a …
Designed Fabrication of Phloretin-Loaded Propylene Glycol Binary Ethosomes: Stability, Skin Permeability and Antioxidant Activity.
Zhang M, Zhuang X, Li S, Wang Y, Zhang X, Li J, Wu D. Zhang M, et al. Molecules. 2023 Dec 21;29(1):66. doi: 10.3390/molecules29010066. Molecules. 2023. PMID: 38202649 Free PMC article.
Binary ethosome vesicles have been developed as flexible lipid vesicles for the enhanced physicochemical stability and skin delivery of drugs. This work aimed to prepare phloretin-loaded propylene glycol ethosomes (PHL-PGEs) to improve their stability, ski …
Binary ethosome vesicles have been developed as flexible lipid vesicles for the enhanced physicochemical stability and skin delivery …
Quantification of skin penetration of caffeine and propylene glycol applied topically in a mixture by tailored multivariate curve resolution-alternating least squares of depth-resolved Raman spectra.
Choe C, Pak GJ, Ascencio SM, Darvin ME. Choe C, et al. J Biophotonics. 2023 Dec;16(12):e202300146. doi: 10.1002/jbio.202300146. Epub 2023 Aug 26. J Biophotonics. 2023. PMID: 37556739
The quantitative determination of topically applied substances in the skin is severely limited and represents a challenging task. The porcine skin ex vivo was topically treated with a gel containing caffeine (CF) and propylene glycol (PG), and depth-re …
The quantitative determination of topically applied substances in the skin is severely limited and represents a challenging task. The …
The Molecular Mechanism of Propylene Glycol Monocaprylate on Skin Retention: Probing the Dual Roles on the Molecular Mobility and Collagen Connection in Roflumilast Cream.
Liu Y, Liu C, Jia W, Xu W, Quan P, Fang L. Liu Y, et al. AAPS PharmSciTech. 2022 May 9;23(5):136. doi: 10.1208/s12249-022-02284-y. AAPS PharmSciTech. 2022. PMID: 35534759
The present work was to construct a roflumilast (ROF) cream for the treatment of psoriasis and clarify the dual roles of propylene glycol monocaprylate (PGM) in both molecular mobility of the cream, and drug-skin miscibility via drug-PGM-ceramide and drug-PGM …
The present work was to construct a roflumilast (ROF) cream for the treatment of psoriasis and clarify the dual roles of propylene …
Safety assessment of propylene glycol, tripropylene glycol, and PPGs as used in cosmetics.
Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler D, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Fiume MM, et al. Int J Toxicol. 2012 Sep-Oct;31(5 Suppl):245S-60S. doi: 10.1177/1091581812461381. Int J Toxicol. 2012. PMID: 23064775 Review.
Propylene glycol is an aliphatic alcohol that functions as a skin conditioning agent, viscosity decreasing agent, solvent, and fragrance ingredient in cosmetics. ...Propylene glycol is generally nontoxic and is noncarcinogenic. Clinical studies …
Propylene glycol is an aliphatic alcohol that functions as a skin conditioning agent, viscosity decreasing agent, solve …
Skin reactions to propylene glycol.
Hannuksela M, Pirilä V, Salo OP. Hannuksela M, et al. Contact Dermatitis. 1975;1(2):112-6. doi: 10.1111/j.1600-0536.1975.tb05336.x. Contact Dermatitis. 1975. PMID: 233872
Propylene glycol (PG), ethylene glycol (EG), and polyethylene glycol 400 (PEG 400) were tested, as is, in a total of 1,556 cases of eczema using the chamber test method. ...In them, positive reactions were elicited by testing with high dilutions of PG …
Propylene glycol (PG), ethylene glycol (EG), and polyethylene glycol 400 (PEG 400) were tested, as is, in a tota …
Ex vivo (human skin) and in vivo (minipig) permeation of propylene glycol applied as topical crisaborole ointment, 2.
Thombre A, Tse S, Yeoh T, Chen R, North R, Brown M. Thombre A, et al. Int J Pharm. 2020 Feb 25;576:118847. doi: 10.1016/j.ijpharm.2019.118847. Epub 2019 Nov 21. Int J Pharm. 2020. PMID: 31759994
Crisaborole ointment, 2%, is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. It contains 9% w/w propylene glycol (PG). Although PG is generally considered to be safe when used as a pharmaceutical excipient or fo …
Crisaborole ointment, 2%, is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. It conta …
Using Raman Spectroscopy in Studying the Effect of Propylene Glycol, Oleic Acid, and Their Combination on the Rat Skin.
Atef E, Altuwaijri N. Atef E, et al. AAPS PharmSciTech. 2018 Jan;19(1):114-122. doi: 10.1208/s12249-017-0800-7. Epub 2017 Jun 15. AAPS PharmSciTech. 2018. PMID: 28620762
The permeability enhancement effect of oleic acid (OA) and propylene glycol (PG) as well as their (1:1 v/v) combined mixture was studied using rat skin. ...The skin histology proved that the skin integrity has been maintained during experiments …
The permeability enhancement effect of oleic acid (OA) and propylene glycol (PG) as well as their (1:1 v/v) combined mixture w …
1,263 results