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Year Number of Results
1970 2
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1979 1
1981 4
1982 2
1983 2
1984 4
1985 3
1986 3
1987 3
1989 6
1991 3
1992 2
1993 7
1994 6
1995 1
1996 1
1997 2
1998 2
1999 2
2000 8
2001 6
2002 5
2003 1
2004 4
2005 5
2006 6
2007 5
2008 3
2009 5
2010 5
2011 3
2012 7
2013 5
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2015 6
2016 6
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2019 13
2020 10
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2022 6
2023 9
2024 2

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198 results

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Page 1
Polyacetal-Based Combination Therapy for the Treatment of Prostate Cancer.
Plyduang T, Armiñán A, Movellan J, England RM, Wiwattanapatapee R, Vicent MJ. Plyduang T, et al. Macromol Rapid Commun. 2018 Oct;39(19):e1800265. doi: 10.1002/marc.201800265. Epub 2018 Jul 30. Macromol Rapid Commun. 2018. PMID: 30062740
We have employed curcumin (Curc) and diethylstilbestrol (DES) to synthesize a series of polyacetal (PA)-based combination conjugates for prostate cancer (PCa) treatment. ...
We have employed curcumin (Curc) and diethylstilbestrol (DES) to synthesize a series of polyacetal (PA)-based combination conjugates …
Degradable Spirocyclic Polyacetal-Based Core-Amphiphilic Assemblies for Encapsulation and Release of Hydrophobic Cargo.
Andrade-Gagnon B, Bélanger-Bouliga M, Trang Nguyen P, Nguyen THD, Bourgault S, Nazemi A. Andrade-Gagnon B, et al. Nanomaterials (Basel). 2021 Jan 10;11(1):161. doi: 10.3390/nano11010161. Nanomaterials (Basel). 2021. PMID: 33435172 Free PMC article.
In addition to acid sensitivity, they benefit from conformational rigidity that is otherwise not attainable by their non-spirocyclic analogs. Herein, amphiphilic spirocyclic polyacetals are synthesized by Cu-catalyzed alkyne-azide "click" polymerization. ...
In addition to acid sensitivity, they benefit from conformational rigidity that is otherwise not attainable by their non-spirocyclic analogs …
Cellulose-Derived Functional Polyacetal by Cationic Ring-Opening Polymerization of Levoglucosenyl Methyl Ether.
Debsharma T, Yagci Y, Schlaad H. Debsharma T, et al. Angew Chem Int Ed Engl. 2019 Dec 16;58(51):18492-18495. doi: 10.1002/anie.201908458. Epub 2019 Oct 25. Angew Chem Int Ed Engl. 2019. PMID: 31509324 Free PMC article.
The unsaturated bicyclic acetal levoglucosenyl methyl ether was readily obtained from sustainable feedstock (cellulose) and polymerized by cationic ring-opening polymerization to produce a semicrystalline thermoplastic unsaturated polyacetal with relatively high apparent m …
The unsaturated bicyclic acetal levoglucosenyl methyl ether was readily obtained from sustainable feedstock (cellulose) and polymerized by c …
In Vivo Antitumor and Antimetastatic Efficacy of a Polyacetal-Based Paclitaxel Conjugate for Prostate Cancer Therapy.
Fernández Y, Movellan J, Foradada L, Giménez V, García-Aranda N, Mancilla S, Armiñán A, Borgos SE, Hyldbakk A, Bogdanska A, Gobbo OL, Prina-Mello A, Ponti J, Calzolai L, Zagorodko O, Gallon E, Niño-Pariente A, Paul A, Schwartz S Jr, Abasolo I, Vicent MJ. Fernández Y, et al. Adv Healthc Mater. 2022 Apr;11(7):e2101544. doi: 10.1002/adhm.202101544. Epub 2021 Nov 10. Adv Healthc Mater. 2022. PMID: 34706167
In the pursuit of high molecular weight, biodegradable, and pH-responsive polymeric carriers, one conjugates PTX to a polyacetal-based nanocarrier to yield a tert-Ser-PTX polyacetal conjugate. tert-Ser-PTX conjugate provides sustained release of PTX over 2 weeks in …
In the pursuit of high molecular weight, biodegradable, and pH-responsive polymeric carriers, one conjugates PTX to a polyacetal-base …
Main-chain polyacetal conjugates with HIF-1 inhibitors: temperature-responsive, pH-degradable drug delivery vehicles.
Samanta S , De Silva CC , Leophairatana P , Koberstein JT . Samanta S , et al. J Mater Chem B. 2018 Jan 28;6(4):666-674. doi: 10.1039/c7tb01417a. Epub 2018 Jan 15. J Mater Chem B. 2018. PMID: 32254495
Main-chain polymer-drug conjugates are prepared from polyacetals (PA) and three hydrophobic diol-based HIF-1 inhibitors. ...
Main-chain polymer-drug conjugates are prepared from polyacetals (PA) and three hydrophobic diol-based HIF-1 inhibitors. ...
Experience with specially designed pored polyacetal mold dressing method used in McIndoe-style vaginoplasty.
Han SE, Go JY, Choi DS, Seo GH, Lim SY. Han SE, et al. J Pediatr Urol. 2017 Dec;13(6):621.e1-621.e6. doi: 10.1016/j.jpurol.2017.05.014. Epub 2017 Jun 16. J Pediatr Urol. 2017. PMID: 28711548
The postoperative mean vaginal length was 9.5 cm in nine patients who used the mold regularly. In all cases in which a pored polyacetal mold was used, skin engraftment was successfully maintained without partial skin graft loss or infection. ...Although a constant follow-u …
The postoperative mean vaginal length was 9.5 cm in nine patients who used the mold regularly. In all cases in which a pored polyacetal …
pH-Responsive Polyacetal-Protein Conjugates Designed for Polymer Masked-Unmasked Protein Therapy (PUMPT).
Escalona GR, Sanchis J, Vicent MJ. Escalona GR, et al. Macromol Biosci. 2018 Jan;18(1). doi: 10.1002/mabi.201700302. Epub 2017 Dec 6. Macromol Biosci. 2018. PMID: 29211345
An acidic-pH triggered PUMPT system is described herein employing biodegradable polyacetals (PAs) and trypsin as a model protein. While this system protects trypsin activity at the neutral pH of the bloodstream, acidic pH (characteristic of disease sites, tissue damage, or …
An acidic-pH triggered PUMPT system is described herein employing biodegradable polyacetals (PAs) and trypsin as a model protein. Whi …
Fabrication of zwitterionic and pH-responsive polyacetal dendrimers for anticancer drug delivery.
Wang Y, Huang D, Wang X, Yang F, Shen H, Wu D. Wang Y, et al. Biomater Sci. 2019 Aug 1;7(8):3238-3248. doi: 10.1039/c9bm00606k. Epub 2019 Jun 5. Biomater Sci. 2019. PMID: 31165798
More importantly, effected by the charge shielding of zwitterions on the surface of polyacetal dendrimers, these DOX-loaded nanoparticles exhibited extremely significant pH-responsive drug release behaviors and remarkable anticancer activity. Thus, we believe that this wor …
More importantly, effected by the charge shielding of zwitterions on the surface of polyacetal dendrimers, these DOX-loaded nanoparti …
Polyacetal-doxorubicin conjugates designed for pH-dependent degradation.
Tomlinson R, Heller J, Brocchini S, Duncan R. Tomlinson R, et al. Bioconjug Chem. 2003 Nov-Dec;14(6):1096-106. doi: 10.1021/bc030028a. Bioconjug Chem. 2003. PMID: 14624622
Terpolymerization of poly(ethylene glycol) (PEG), divinyl ethers, and serinol can be used to synthesize water soluble, hydrolytically labile, amino-pendent polyacetals (APEGs) suitable for drug conjugation. As these polyacetals display pH-dependent degradation (with …
Terpolymerization of poly(ethylene glycol) (PEG), divinyl ethers, and serinol can be used to synthesize water soluble, hydrolytically labile …
Polyacetal-stilbene conjugates - The first examples of polymer therapeutics for the inhibition of HIF-1 in the treatment of solid tumours.
England RM, Masiá E, Giménez V, Lucas R, Vicent MJ. England RM, et al. J Control Release. 2012 Dec 28;164(3):314-22. doi: 10.1016/j.jconrel.2012.08.017. Epub 2012 Aug 23. J Control Release. 2012. PMID: 22940127
These molecules were incorporated into a poly(ethylene glycol) (PEG) based polyacetal system using a reaction of short PEG chains with di(ethylene glycol) divinyl ether units and an acid catalyst and without the need for biodegradable linkers. ...More importantly, these co …
These molecules were incorporated into a poly(ethylene glycol) (PEG) based polyacetal system using a reaction of short PEG chains wit …
198 results