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Cancer Lett. 2012 Dec 31;327(1-2):73-89. doi: 10.1016/j.canlet.2011.12.038. Epub 2012 Jan 15.

Base excision repair and cancer.

Author information

1
Department of Microbiology and Molecular Genetics, The Markey Center for Molecular Genetics, University of Vermont, Burlington, 05405-0068, United States. susan.wallace@uvm.edu

Abstract

Base excision repair is the system used from bacteria to man to remove the tens of thousands of endogenous DNA damages produced daily in each human cell. Base excision repair is required for normal mammalian development and defects have been associated with neurological disorders and cancer. In this paper we provide an overview of short patch base excision repair in humans and summarize current knowledge of defects in base excision repair in mouse models and functional studies on short patch base excision repair germ line polymorphisms and their relationship to cancer. The biallelic germ line mutations that result in MUTYH-associated colon cancer are also discussed.

PMID:
22252118
PMCID:
PMC3361536
DOI:
10.1016/j.canlet.2011.12.038
[Indexed for MEDLINE]
Free PMC Article
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