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Items: 1 to 20 of 599

1.

Improved anti-tumor efficacy of chimeric antigen receptor T cells that secrete single-domain antibody fragments.

Xie YJ, Dougan M, Ingram JR, Pishesha N, Fang T, Momin N, Ploegh HL.

Cancer Immunol Res. 2020 Feb 4. pii: canimm.0734.2019. doi: 10.1158/2326-6066.CIR-19-0734. [Epub ahead of print]

PMID:
32019780
2.

Neoleukin-2 enhances anti-tumour immunity downstream of peptide vaccination targeted by an anti-MHC class II VHH.

Crowley SJ, Bruck PT, Bhuiyan MA, Mitchell-Gears A, Walsh MJ, Zhangxu K, Ali LR, Jeong HJ, Ingram JR, Knipe DM, Ploegh HL, Dougan M, Dougan SK.

Open Biol. 2020 Feb;10(2):190235. doi: 10.1098/rsob.190235. Epub 2020 Feb 5.

3.

Site-Specific Sequential Protein Labeling Catalyzed by a Single Recombinant Ligase.

Rehm FBH, Harmand TJ, Yap K, Durek T, Craik DJ, Ploegh HL.

J Am Chem Soc. 2019 Oct 30;141(43):17388-17393. doi: 10.1021/jacs.9b09166. Epub 2019 Oct 16.

PMID:
31573802
4.

A nanobody that recognizes a 14-residue peptide epitope in the E2 ubiquitin-conjugating enzyme UBC6e modulates its activity.

Ling J, Cheloha RW, McCaul N, Sun ZJ, Wagner G, Ploegh HL.

Mol Immunol. 2019 Oct;114:513-523. doi: 10.1016/j.molimm.2019.08.008. Epub 2019 Sep 10.

PMID:
31518855
5.

CD82 controls CpG-dependent TLR9 signaling.

Khan NS, Lukason DP, Feliu M, Ward RA, Lord AK, Reedy JL, Ramirez-Ortiz ZG, Tam JM, Kasperkovitz PV, Negoro PE, Vyas TD, Xu S, Brinkmann MM, Acharaya M, Artavanis-Tsakonas K, Frickel EM, Becker CE, Dagher Z, Kim YM, Latz E, Ploegh HL, Mansour MK, Miranti CK, Levitz SM, Vyas JM.

FASEB J. 2019 Nov;33(11):12500-12514. doi: 10.1096/fj.201901547R. Epub 2019 Aug 13.

6.

Recognition of Class II MHC Peptide Ligands That Contain β-Amino Acids.

Cheloha RW, Woodham AW, Bousbaine D, Wang T, Liu S, Sidney J, Sette A, Gellman SH, Ploegh HL.

J Immunol. 2019 Sep 15;203(6):1619-1628. doi: 10.4049/jimmunol.1900536. Epub 2019 Aug 7.

PMID:
31391235
7.

Immuno-PET identifies the myeloid compartment as a key contributor to the outcome of the antitumor response under PD-1 blockade.

Rashidian M, LaFleur MW, Verschoor VL, Dongre A, Zhang Y, Nguyen TH, Kolifrath S, Aref AR, Lau CJ, Paweletz CP, Bu X, Freeman GJ, Barrasa MI, Weinberg RA, Sharpe AH, Ploegh HL.

Proc Natl Acad Sci U S A. 2019 Aug 20;116(34):16971-16980. doi: 10.1073/pnas.1905005116. Epub 2019 Aug 2.

8.

Internalization of Influenza Virus and Cell Surface Proteins Monitored by Site-Specific Conjugation of Protease-Sensitive Probes.

Cheloha RW, Li Z, Bousbaine D, Woodham AW, Perrin P, Volarić J, Ploegh HL.

ACS Chem Biol. 2019 Aug 16;14(8):1836-1844. doi: 10.1021/acschembio.9b00493. Epub 2019 Jul 26.

PMID:
31348637
9.

QnAs with Hidde L. Ploegh.

Nair P.

Proc Natl Acad Sci U S A. 2019 Jun 18;116(25):12123-12125. doi: 10.1073/pnas.1908701116. Epub 2019 Jun 3. No abstract available.

10.

Noninvasive imaging of tumor progression, metastasis, and fibrosis using a nanobody targeting the extracellular matrix.

Jailkhani N, Ingram JR, Rashidian M, Rickelt S, Tian C, Mak H, Jiang Z, Ploegh HL, Hynes RO.

Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14181-14190. doi: 10.1073/pnas.1817442116. Epub 2019 May 8. Erratum in: Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18745.

11.

Remodeling of the Tumor Microenvironment by a Chemokine/Anti-PD-L1 Nanobody Fusion Protein.

Fang T, Li R, Li Z, Cho J, Guzman JS, Kamm RD, Ploegh HL.

Mol Pharm. 2019 Jun 3;16(6):2838-2844. doi: 10.1021/acs.molpharmaceut.9b00078. Epub 2019 Apr 29.

PMID:
31013423
12.

Nanobody-based CAR T cells that target the tumor microenvironment inhibit the growth of solid tumors in immunocompetent mice.

Xie YJ, Dougan M, Jailkhani N, Ingram J, Fang T, Kummer L, Momin N, Pishesha N, Rickelt S, Hynes RO, Ploegh H.

Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7624-7631. doi: 10.1073/pnas.1817147116. Epub 2019 Apr 1. Erratum in: Proc Natl Acad Sci U S A. 2019 Aug 13;116(33):16656.

13.

Protection of tissue physicochemical properties using polyfunctional crosslinkers.

Park YG, Sohn CH, Chen R, McCue M, Yun DH, Drummond GT, Ku T, Evans NB, Oak HC, Trieu W, Choi H, Jin X, Lilascharoen V, Wang J, Truttmann MC, Qi HW, Ploegh HL, Golub TR, Chen SC, Frosch MP, Kulik HJ, Lim BK, Chung K.

Nat Biotechnol. 2018 Dec 17. doi: 10.1038/nbt.4281. [Epub ahead of print]

14.

Targeting small molecule drugs to T cells with antibody-directed cell-penetrating gold nanoparticles.

Yang YS, Moynihan KD, Bekdemir A, Dichwalkar TM, Noh MM, Watson N, Melo M, Ingram J, Suh H, Ploegh H, Stellacci FR, Irvine DJ.

Biomater Sci. 2018 Dec 18;7(1):113-124. doi: 10.1039/c8bm01208c.

15.

Nanobody immunostaining for correlated light and electron microscopy with preservation of ultrastructure.

Fang T, Lu X, Berger D, Gmeiner C, Cho J, Schalek R, Ploegh H, Lichtman J.

Nat Methods. 2018 Dec;15(12):1029-1032. doi: 10.1038/s41592-018-0177-x. Epub 2018 Nov 5.

16.

Galectin-3 Regulates γ-Herpesvirus Specific CD8 T Cell Immunity.

Kaur M, Kumar D, Butty V, Singh S, Esteban A, Fink GR, Ploegh HL, Sehrawat S.

iScience. 2018 Nov 30;9:101-119. doi: 10.1016/j.isci.2018.10.013. Epub 2018 Oct 17.

17.

Targeted Delivery of Cyclotides via Conjugation to a Nanobody.

Kwon S, Duarte JN, Li Z, Ling JJ, Cheneval O, Durek T, Schroeder CI, Craik DJ, Ploegh HL.

ACS Chem Biol. 2018 Oct 19;13(10):2973-2980. doi: 10.1021/acschembio.8b00653. Epub 2018 Oct 5.

PMID:
30248263
18.

One-Pot Dual Labeling of IgG 1 and Preparation of C-to-C Fusion Proteins Through a Combination of Sortase A and Butelase 1.

Harmand TJ, Bousbaine D, Chan A, Zhang X, Liu DR, Tam JP, Ploegh HL.

Bioconjug Chem. 2018 Oct 17;29(10):3245-3249. doi: 10.1021/acs.bioconjchem.8b00563. Epub 2018 Sep 21.

19.

Sortase A: A Model for Transpeptidation and Its Biological Applications.

Pishesha N, Ingram JR, Ploegh HL.

Annu Rev Cell Dev Biol. 2018 Oct 6;34:163-188. doi: 10.1146/annurev-cellbio-100617-062527. Epub 2018 Aug 15. Review.

PMID:
30110557
20.

Preparation of bispecific antibody-protein adducts by site-specific chemo-enzymatic conjugation.

Bartels L, Ploegh HL, Spits H, Wagner K.

Methods. 2019 Feb 1;154:93-101. doi: 10.1016/j.ymeth.2018.07.013. Epub 2018 Aug 3.

PMID:
30081077

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