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Depletion of Jmjd1c impairs adipogenesis in murine 3T3-L1 cells.
Buerger F, Müller S, Ney N, Weiner J, Heiker JT, Kallendrusch S, Kovacs P, Schleinitz D, Thiery J, Stadler SC, Burkhardt R. Buerger F, et al. Biochim Biophys Acta Mol Basis Dis. 2017 Jul;1863(7):1709-1717. doi: 10.1016/j.bbadis.2017.05.011. Epub 2017 May 10. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 28501567 Free article.
Here, we explored the potential role of Jmjd1c in white adipocyte differentiation. To investigate the relevance of Jmjd1c in adipogenesis, murine 3T3-L1 preadipocyte cells with transient knock-down of Jmjd1c (3T3_Jmjd1c) were generated. ...In line with these observations w …
Here, we explored the potential role of Jmjd1c in white adipocyte differentiation. To investigate the relevance of Jmjd1c in adipogenesis …
The key microRNA on lipid droplet formation during adipogenesis from human mesenchymal stem cells.
Yi X, Liu J, Wu P, Gong Y, Xu X, Li W. Yi X, et al. J Cell Physiol. 2020 Jan;235(1):328-338. doi: 10.1002/jcp.28972. Epub 2019 Jun 18. J Cell Physiol. 2020. PMID: 31210354
MicroRNAs (miRNAs), the potential regulator of adipogenesis, markedly characterized by lipid droplet (LD) formation, play an important role in progenitor-cell differentiation into adipocytes. ...Except for the known miRNA hsa-miR-1908 regulating adipogenesis, five m …
MicroRNAs (miRNAs), the potential regulator of adipogenesis, markedly characterized by lipid droplet (LD) formation, play an importan …
A Polymorphism in a gene encoding Perilipin 4 is associated with height but not with bone measures in individuals from the Framingham Osteoporosis Study.
Cusano NE, Kiel DP, Demissie S, Karasik D, Adrienne Cupples L, Corella D, Gao Q, Richardson K, Yiannakouris N, Ordovas JM. Cusano NE, et al. Calcif Tissue Int. 2012 Feb;90(2):96-107. doi: 10.1007/s00223-011-9552-7. Epub 2011 Dec 31. Calcif Tissue Int. 2012. PMID: 22210160 Free PMC article.
Perilipin 1 (PLIN1) and Perilipin 4 (PLIN4) are members of the PATS family of genes and are involved in lipolysis of intracellular lipid deposits. ...In a large study sample of men and women, we found a significant association between one SNP in PLIN4 and height but …
Perilipin 1 (PLIN1) and Perilipin 4 (PLIN4) are members of the PATS family of genes and are involved in lipolysis of intracellular li …
HOPX regulates bone marrow-derived mesenchymal stromal cell fate determination via suppression of adipogenic gene pathways.
Hng CH, Camp E, Anderson P, Breen J, Zannettino A, Gronthos S. Hng CH, et al. Sci Rep. 2020 Jul 9;10(1):11345. doi: 10.1038/s41598-020-68261-2. Sci Rep. 2020. PMID: 32647304 Free PMC article.
HOPX gene knockdown and overexpression studies demonstrated that HOPX is a promoter of BMSC proliferation and an inhibitor of adipogenesis. However, functional studies failed to observe any affect by HOPX on BMSC osteogenic differentiation. RNA-seq analysis of HOPX overexp …
HOPX gene knockdown and overexpression studies demonstrated that HOPX is a promoter of BMSC proliferation and an inhibitor of adipogenesi …
Five genomic regions have a major impact on fat composition in Iberian pigs.
Pena RN, Noguera JL, García-Santana MJ, González E, Tejeda JF, Ros-Freixedes R, Ibáñez-Escriche N. Pena RN, et al. Sci Rep. 2019 Feb 14;9(1):2031. doi: 10.1038/s41598-019-38622-7. Sci Rep. 2019. PMID: 30765794 Free PMC article.
In particular, five regions with Bayes Factor >100 (SSC2 and SSC7) or >50 (SSC2 and SSC12) explained an important fraction of the genetic variance for miristic, palmitoleic, monounsaturated (>14%), oleic (>10%) and polyunsaturated (>5%) fatty acids. Six genes (RXRB …
In particular, five regions with Bayes Factor >100 (SSC2 and SSC7) or >50 (SSC2 and SSC12) explained an important fraction of the gene …
OP9 mouse stromal cells rapidly differentiate into adipocytes: characterization of a useful new model of adipogenesis.
Wolins NE, Quaynor BK, Skinner JR, Tzekov A, Park C, Choi K, Bickel PE. Wolins NE, et al. J Lipid Res. 2006 Feb;47(2):450-60. doi: 10.1194/jlr.D500037-JLR200. Epub 2005 Nov 30. J Lipid Res. 2006. PMID: 16319419 Free article.
We have investigated the capacity of OP9 cells, a line of bone marrow-derived mouse stromal cells, to recapitulate adipogenesis. When OP9 cells are given any one of three adipogenic stimuli, they rapidly accumulate triacylglycerol, assume adipocyte morphology, and express …
We have investigated the capacity of OP9 cells, a line of bone marrow-derived mouse stromal cells, to recapitulate adipogenesis. When …
Expression analysis of human adipose-derived stem cells during in vitro differentiation to an adipocyte lineage.
Satish L, Krill-Burger JM, Gallo PH, Etages SD, Liu F, Philips BJ, Ravuri S, Marra KG, LaFramboise WA, Kathju S, Rubin JP. Satish L, et al. BMC Med Genomics. 2015 Jul 24;8:41. doi: 10.1186/s12920-015-0119-8. BMC Med Genomics. 2015. PMID: 26205789 Free PMC article.
In addition to confirming differential expression of known markers of adipogenesis (e.g., FABP4, ADIPOQ, PLIN4), multiple genes and signaling pathways not previously known to be involved in regulating adipogenesis were identified (e.g. ...This is the first st …
In addition to confirming differential expression of known markers of adipogenesis (e.g., FABP4, ADIPOQ, PLIN4), multiple gene …
On the formation of lipid droplets in human adipocytes: the organization of the perilipin-vimentin cortex.
Heid H, Rickelt S, Zimbelmann R, Winter S, Schumacher H, Dörflinger Y, Kuhn C, Franke WW. Heid H, et al. PLoS One. 2014 Feb 28;9(2):e90386. doi: 10.1371/journal.pone.0090386. eCollection 2014. PLoS One. 2014. PMID: 24587346 Free PMC article.
We report on the heterogeneity and diversity of lipid droplets (LDs) in early stages of adipogenesis by elucidating the cell and molecular biology of amphiphilic and cytoskeletal proteins regulating and stabilizing the generation of LDs in human adipose cells. ...
We report on the heterogeneity and diversity of lipid droplets (LDs) in early stages of adipogenesis by elucidating the cell and mole …