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Items: 1 to 20 of 200

1.

Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function.

Field CS, Baixauli F, Kyle RL, Puleston DJ, Cameron AM, Sanin DE, Hippen KL, Loschi M, Thangavelu G, Corrado M, Edwards-Hicks J, Grzes KM, Pearce EJ, Blazar BR, Pearce EL.

Cell Metab. 2020 Feb 4;31(2):422-437.e5. doi: 10.1016/j.cmet.2019.11.021. Epub 2019 Dec 26.

2.

Metabolic adaptations of tissue-resident immune cells.

Caputa G, Castoldi A, Pearce EJ.

Nat Immunol. 2019 Jul;20(7):793-801. doi: 10.1038/s41590-019-0407-0. Epub 2019 Jun 18. Review.

PMID:
31213715
3.

Polyamines and eIF5A Hypusination Modulate Mitochondrial Respiration and Macrophage Activation.

Puleston DJ, Buck MD, Klein Geltink RI, Kyle RL, Caputa G, O'Sullivan D, Cameron AM, Castoldi A, Musa Y, Kabat AM, Zhang Y, Flachsmann LJ, Field CS, Patterson AE, Scherer S, Alfei F, Baixauli F, Austin SK, Kelly B, Matsushita M, Curtis JD, Grzes KM, Villa M, Corrado M, Sanin DE, Qiu J, Pällman N, Paz K, Maccari ME, Blazar BR, Mittler G, Buescher JM, Zehn D, Rospert S, Pearce EJ, Balabanov S, Pearce EL.

Cell Metab. 2019 Aug 6;30(2):352-363.e8. doi: 10.1016/j.cmet.2019.05.003. Epub 2019 May 23.

4.

Acetate Promotes T Cell Effector Function during Glucose Restriction.

Qiu J, Villa M, Sanin DE, Buck MD, O'Sullivan D, Ching R, Matsushita M, Grzes KM, Winkler F, Chang CH, Curtis JD, Kyle RL, Van Teijlingen Bakker N, Corrado M, Haessler F, Alfei F, Edwards-Hicks J, Maggi LB Jr, Zehn D, Egawa T, Bengsch B, Klein Geltink RI, Jenuwein T, Pearce EJ, Pearce EL.

Cell Rep. 2019 May 14;27(7):2063-2074.e5. doi: 10.1016/j.celrep.2019.04.022.

5.

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species-mediated DNA damage.

Cameron AM, Castoldi A, Sanin DE, Flachsmann LJ, Field CS, Puleston DJ, Kyle RL, Patterson AE, Hässler F, Buescher JM, Kelly B, Pearce EL, Pearce EJ.

Nat Immunol. 2019 Apr;20(4):420-432. doi: 10.1038/s41590-019-0336-y. Epub 2019 Mar 11.

PMID:
30858618
6.

Metabolic interventions in the immune response to cancer.

O'Sullivan D, Sanin DE, Pearce EJ, Pearce EL.

Nat Rev Immunol. 2019 May;19(5):324-335. doi: 10.1038/s41577-019-0140-9. Review.

PMID:
30820043
7.

Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2.

Sanin DE, Matsushita M, Klein Geltink RI, Grzes KM, van Teijlingen Bakker N, Corrado M, Kabat AM, Buck MD, Qiu J, Lawless SJ, Cameron AM, Villa M, Baixauli F, Patterson AE, Hässler F, Curtis JD, O'Neill CM, O'Sullivan D, Wu D, Mittler G, Huang SC, Pearce EL, Pearce EJ.

Immunity. 2018 Dec 18;49(6):1021-1033.e6. doi: 10.1016/j.immuni.2018.10.011.

8.

Schistosoma mansoni Infection-Induced Transcriptional Changes in Hepatic Macrophage Metabolism Correlate With an Athero-Protective Phenotype.

Cortes-Selva D, Elvington AF, Ready A, Rajwa B, Pearce EJ, Randolph GJ, Fairfax KC.

Front Immunol. 2018 Nov 12;9:2580. doi: 10.3389/fimmu.2018.02580. eCollection 2018.

9.

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development.

O'Sullivan D, van der Windt GJW, Huang SC, Curtis JD, Chang CH, Buck MD, Qiu J, Smith AM, Lam WY, DiPlato LM, Hsu FF, Birnbaum MJ, Pearce EJ, Pearce EL.

Immunity. 2018 Aug 21;49(2):375-376. doi: 10.1016/j.immuni.2018.07.018. No abstract available.

10.

Disrupting metabolism to treat autoimmunity.

Matsushita M, Pearce EJ.

Science. 2018 Apr 27;360(6387):377-378. doi: 10.1126/science.aat4984. No abstract available.

PMID:
29700251
11.

Immunometabolism in 2017: Driving immunity: all roads lead to metabolism.

Pearce EJ, Pearce EL.

Nat Rev Immunol. 2018 Feb;18(2):81-82. doi: 10.1038/nri.2017.139. Epub 2017 Dec 11. No abstract available.

12.

Mitochondrial Priming by CD28.

Klein Geltink RI, O'Sullivan D, Corrado M, Bremser A, Buck MD, Buescher JM, Firat E, Zhu X, Niedermann G, Caputa G, Kelly B, Warthorst U, Rensing-Ehl A, Kyle RL, Vandersarren L, Curtis JD, Patterson AE, Lawless S, Grzes K, Qiu J, Sanin DE, Kretz O, Huber TB, Janssens S, Lambrecht BN, Rambold AS, Pearce EJ, Pearce EL.

Cell. 2017 Oct 5;171(2):385-397.e11. doi: 10.1016/j.cell.2017.08.018. Epub 2017 Sep 14.

13.

Treg Cells Survive and Thrive in Inhospitable Environments.

Grzes KM, Field CS, Pearce EJ.

Cell Metab. 2017 Jun 6;25(6):1213-1215. doi: 10.1016/j.cmet.2017.05.012.

14.

MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells.

Jones RG, Pearce EJ.

Immunity. 2017 May 16;46(5):730-742. doi: 10.1016/j.immuni.2017.04.028. Review.

15.

Inflammation by way of macrophage metabolism.

Kabat AM, Pearce EJ.

Science. 2017 May 5;356(6337):488-489. doi: 10.1126/science.aan2691. No abstract available.

PMID:
28473549
16.

Metabolism and acetylation in innate immune cell function and fate.

Cameron AM, Lawless SJ, Pearce EJ.

Semin Immunol. 2016 Oct;28(5):408-416. doi: 10.1016/j.smim.2016.10.003. Epub 2016 Oct 27. Review.

PMID:
28340958
17.

The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites.

Kaiko GE, Ryu SH, Koues OI, Collins PL, Solnica-Krezel L, Pearce EJ, Pearce EL, Oltz EM, Stappenbeck TS.

Cell. 2016 Nov 3;167(4):1137. doi: 10.1016/j.cell.2016.10.034. No abstract available.

18.

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation.

Huang SC, Smith AM, Everts B, Colonna M, Pearce EL, Schilling JD, Pearce EJ.

Immunity. 2016 Oct 18;45(4):817-830. doi: 10.1016/j.immuni.2016.09.016.

19.

The Transcriptional Repressor Polycomb Group Factor 6, PCGF6, Negatively Regulates Dendritic Cell Activation and Promotes Quiescence.

Boukhaled GM, Cordeiro B, Deblois G, Dimitrov V, Bailey SD, Holowka T, Domi A, Guak H, Chiu HH, Everts B, Pearce EJ, Lupien M, White JH, Krawczyk CM.

Cell Rep. 2016 Aug 16;16(7):1829-37. doi: 10.1016/j.celrep.2016.07.026. Epub 2016 Aug 4.

20.

TPL-2 Regulates Macrophage Lipid Metabolism and M2 Differentiation to Control TH2-Mediated Immunopathology.

Kannan Y, Perez-Lloret J, Li Y, Entwistle LJ, Khoury H, Papoutsopoulou S, Mahmood R, Mansour NR, Ching-Cheng Huang S, Pearce EJ, Pedro S de Carvalho L, Ley SC, Wilson MS.

PLoS Pathog. 2016 Aug 3;12(8):e1005783. doi: 10.1371/journal.ppat.1005783. eCollection 2016 Aug.

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