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Items: 1 to 20 of 36


Assays for tyrosine phosphorylation in human cells.

Kruk M, Widstrom N, Jena S, Wolter NL, Blankenhorn JF, Abdalla I, Yang TY, Parker LL.

Methods Enzymol. 2019;626:375-406. doi: 10.1016/bs.mie.2019.06.026. Epub 2019 Jul 24.


The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair.

Moreno NS, Liu J, Haas KM, Parker LL, Chakraborty C, Kron SJ, Hodges K, Miller LD, Langefeld C, Robinson PJ, Lelièvre SA, Vidi PA.

Nucleic Acids Res. 2019 Sep 12. pii: gkz802. doi: 10.1093/nar/gkz802. [Epub ahead of print] No abstract available.


The nuclear structural protein NuMA is a negative regulator of 53BP1 in DNA double-strand break repair.

Salvador Moreno N, Liu J, Haas KM, Parker LL, Chakraborty C, Kron SJ, Hodges K, Miller LD, Langefeld C, Robinson PJ, Lelièvre SA, Vidi PA.

Nucleic Acids Res. 2019 Apr 8;47(6):2703-2715. doi: 10.1093/nar/gkz138.


A Gradient in Metaphase Tension Leads to a Scaled Cellular Response in Mitosis.

Mukherjee S, Sandri BJ, Tank D, McClellan M, Harasymiw LA, Yang Q, Parker LL, Gardner MK.

Dev Cell. 2019 Apr 8;49(1):63-76.e10. doi: 10.1016/j.devcel.2019.01.018. Epub 2019 Feb 21.


Multiomic Profiling of Tyrosine Kinase Inhibitor-Resistant K562 Cells Suggests Metabolic Reprogramming To Promote Cell Survival.

Noel BM, Ouellette SB, Marholz L, Dickey D, Navis C, Yang TY, Nguyen V, Parker SJ, Bernlohr D, Sachs Z, Parker LL.

J Proteome Res. 2019 Apr 5;18(4):1842-1856. doi: 10.1021/acs.jproteome.9b00028. Epub 2019 Feb 21.


High-throughput Identification of FLT3 Wild-type and Mutant Kinase Substrate Preferences and Application to Design of Sensitive In Vitro Kinase Assay Substrates.

Perez M, Blankenhorn J, Murray KJ, Parker LL.

Mol Cell Proteomics. 2019 Mar;18(3):477-489. doi: 10.1074/mcp.RA118.001111. Epub 2018 Dec 12.


In Silico Design and in Vitro Characterization of Universal Tyrosine Kinase Peptide Substrates.

Marholz LJ, Zeringo NA, Lou HJ, Turk BE, Parker LL.

Biochemistry. 2018 Mar 27;57(12):1847-1851. doi: 10.1021/acs.biochem.8b00044. Epub 2018 Mar 12.


N6-methyladenine is an epigenetic marker of mammalian early life stress.

Kigar SL, Chang L, Guerrero CR, Sehring JR, Cuarenta A, Parker LL, Bakshi VP, Auger AP.

Sci Rep. 2017 Dec 22;7(1):18078. doi: 10.1038/s41598-017-18414-7.


A Cell-Based Assay for Measuring Endogenous BcrAbl Kinase Activity and Inhibitor Resistance.

Ouellette SB, Noel BM, Parker LL.

PLoS One. 2016 Sep 6;11(9):e0161748. doi: 10.1371/journal.pone.0161748. eCollection 2016.


Effect of an endoscopic quality improvement program on adenoma detection rates: a multicenter cluster-randomized controlled trial in a clinical practice setting (EQUIP-3).

Wallace MB, Crook JE, Thomas CS, Staggs E, Parker L, Rex DK.

Gastrointest Endosc. 2017 Mar;85(3):538-545.e4. doi: 10.1016/j.gie.2016.07.042. Epub 2016 Jul 26.


Time-Resolved Proteomic Visualization of Dendrimer Cellular Entry and Trafficking.

Wang L, Yang L, Pan L, Kadasala NR, Xue L, Schuster RJ, Parker LL, Wei A, Tao WA.

J Am Chem Soc. 2015 Oct 14;137(40):12772-12775. doi: 10.1021/jacs.5b07875. Epub 2015 Oct 5.


Multicolored, Tb³⁺-Based Antibody-Free Detection of Multiple Tyrosine Kinase Activities.

Lipchik AM, Perez M, Cui W, Parker LL.

Anal Chem. 2015 Aug 4;87(15):7555-8. doi: 10.1021/acs.analchem.5b02233. Epub 2015 Jul 24.


KINATEST-ID: a pipeline to develop phosphorylation-dependent terbium sensitizing kinase assays.

Lipchik AM, Perez M, Bolton S, Dumrongprechachan V, Ouellette SB, Cui W, Parker LL.

J Am Chem Soc. 2015 Feb 25;137(7):2484-94. doi: 10.1021/ja507164a. Epub 2015 Feb 17.


A time-resolved luminescence biosensor assay for anaplastic lymphoma kinase (ALK) activity.

Cui W, Parker LL.

Chem Commun (Camb). 2015;51(2):362-5. doi: 10.1039/c4cc07453j. Epub 2014 Nov 18.


A tarantula-venom peptide antagonizes the TRPA1 nociceptor ion channel by binding to the S1-S4 gating domain.

Gui J, Liu B, Cao G, Lipchik AM, Perez M, Dekan Z, Mobli M, Daly NL, Alewood PF, Parker LL, King GF, Zhou Y, Jordt SE, Nitabach MN.

Curr Biol. 2014 Mar 3;24(5):473-83. doi: 10.1016/j.cub.2014.01.013. Epub 2014 Feb 13.


A quantitative proteomics-based competition binding assay to characterize pITAM-protein interactions.

Hu L, Yang L, Lipchik AM, Geahlen RL, Parker LL, Tao WA.

Anal Chem. 2013 May 21;85(10):5071-7. doi: 10.1021/ac400359t. Epub 2013 May 8.


Fluorescence lifetime imaging of biosensor peptide phosphorylation in single live cells.

Damayanti NP, Parker LL, Irudayaraj JM.

Angew Chem Int Ed Engl. 2013 Apr 2;52(14):3931-4. doi: 10.1002/anie.201209303. Epub 2013 Feb 28. No abstract available.


A multiple reaction monitoring (MRM) method to detect Bcr-Abl kinase activity in CML using a peptide biosensor.

Yang TY, Eissler CL, Hall MC, Parker LL.

PLoS One. 2013;8(2):e56627. doi: 10.1371/journal.pone.0056627. Epub 2013 Feb 20.


Time-resolved luminescence detection of spleen tyrosine kinase activity through terbium sensitization.

Lipchik AM, Parker LL.

Anal Chem. 2013 Mar 5;85(5):2582-8. doi: 10.1021/ac3023422. Epub 2013 Feb 15.

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