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Items: 1 to 20 of 61


Stable isotope-labelled morphine to study in vivo central and peripheral morphine glucuronidation and brain transport in tolerant mice.

Weinsanto I, Laux-Biehlmann A, Mouheiche J, Maduna T, Delalande F, Chavant V, Gabel F, Darbon P, Charlet A, Poisbeau P, Lamshöft M, Van Dorsselaer A, Cianferani S, Parat MO, Goumon Y.

Br J Pharmacol. 2018 Oct;175(19):3844-3856. doi: 10.1111/bph.14454. Epub 2018 Aug 31.


Effect of Perioperative Opioids on Cancer-Relevant Circulating Parameters: Mu Opioid Receptor and Toll-Like Receptor 4 Activation Potential, and Proteolytic Profile.

Xie N, Matigian N, Vithanage T, Gregory K, Nassar ZD, Cabot PJ, Shaw PN, Kirkpatrick CMJ, Cao KL, Sturgess D, Parat MO.

Clin Cancer Res. 2018 May 15;24(10):2319-2327. doi: 10.1158/1078-0432.CCR-18-0172. Epub 2018 Mar 6.


Lithium reverses mechanical allodynia through a mu opioid-dependent mechanism.

Weinsanto I, Mouheiche J, Laux-Biehlmann A, Aouad M, Maduna T, Petit-Demoulière N, Chavant V, Poisbeau P, Darbon P, Charlet A, Giersch A, Parat MO, Goumon Y.

Mol Pain. 2018 Jan-Dec;14:1744806917754142. doi: 10.1177/1744806917754142. Epub 2018 Jan 21.


Multifunctional Analogs of Kynurenic Acid for the Treatment of Alzheimer's Disease: Synthesis, Pharmacology, and Molecular Modeling Studies.

Deora GS, Kantham S, Chan S, Dighe SN, Veliyath SK, McColl G, Parat MO, McGeary RP, Ross BP.

ACS Chem Neurosci. 2017 Dec 20;8(12):2667-2675. doi: 10.1021/acschemneuro.7b00229. Epub 2017 Sep 8.


Morphine alters the circulating proteolytic profile in mice: functional consequences on cellular migration and invasion.

Xie N, Khabbazi S, Nassar ZD, Gregory K, Vithanage T, Anand-Apte B, Cabot PJ, Sturgess D, Shaw PN, Parat MO.

FASEB J. 2017 Dec;31(12):5208-5216. doi: 10.1096/fj.201700546R. Epub 2017 Aug 7.


Solvent Supercritical Fluid Technologies to Extract Bioactive Compounds from Natural Sources: A Review.

Khaw KY, Parat MO, Shaw PN, Falconer JR.

Molecules. 2017 Jul 14;22(7). pii: E1186. doi: 10.3390/molecules22071186. Review.


Effect of the Biphenyl Neolignan Honokiol on Aβ42-Induced Toxicity in Caenorhabditis elegans, Aβ42 Fibrillation, Cholinesterase Activity, DPPH Radicals, and Iron(II) Chelation.

Kantham S, Chan S, McColl G, Miles JA, Veliyath SK, Deora GS, Dighe SN, Khabbazi S, Parat MO, Ross BP.

ACS Chem Neurosci. 2017 Sep 20;8(9):1901-1912. doi: 10.1021/acschemneuro.7b00071. Epub 2017 Jul 19.


Stably engineered nanobubbles and ultrasound - An effective platform for enhanced macromolecular delivery to representative cells of the retina.

Thakur SS, Ward MS, Popat A, Flemming NB, Parat MO, Barnett NL, Parekh HS.

PLoS One. 2017 May 25;12(5):e0178305. doi: 10.1371/journal.pone.0178305. eCollection 2017.


Bifunctional Succinylated ε-Polylysine-Coated Mesoporous Silica Nanoparticles for pH-Responsive and Intracellular Drug Delivery Targeting the Colon.

Nguyen CT, Webb RI, Lambert LK, Strounina E, Lee EC, Parat MO, McGuckin MA, Popat A, Cabot PJ, Ross BP.

ACS Appl Mater Interfaces. 2017 Mar 22;9(11):9470-9483. doi: 10.1021/acsami.7b00411. Epub 2017 Mar 13.


Activation of μ-opioid receptor and Toll-like receptor 4 by plasma from morphine-treated mice.

Xie N, Gomes FP, Deora V, Gregory K, Vithanage T, Nassar ZD, Cabot PJ, Sturgess D, Shaw PN, Parat MO.

Brain Behav Immun. 2017 Mar;61:244-258. doi: 10.1016/j.bbi.2016.12.002. Epub 2016 Dec 7.


The TLR4-Active Morphine Metabolite Morphine-3-Glucuronide Does Not Elicit Macrophage Classical Activation In Vitro.

Khabbazi S, Xie N, Pu W, Goumon Y, Parat MO.

Front Pharmacol. 2016 Nov 17;7:441. eCollection 2016.


Morphine decreases the pro-angiogenic interaction between breast cancer cells and macrophages in vitro.

Khabbazi S, Nassar ZD, Goumon Y, Parat MO.

Sci Rep. 2016 Aug 12;6:31572. doi: 10.1038/srep31572.


Discovery and Structure-Activity Relationships of a Highly Selective Butyrylcholinesterase Inhibitor by Structure-Based Virtual Screening.

Dighe SN, Deora GS, De la Mora E, Nachon F, Chan S, Parat MO, Brazzolotto X, Ross BP.

J Med Chem. 2016 Aug 25;59(16):7683-9. doi: 10.1021/acs.jmedchem.6b00356. Epub 2016 Jul 26.


Traditional Aboriginal Preparation Alters the Chemical Profile of Carica papaya Leaves and Impacts on Cytotoxicity towards Human Squamous Cell Carcinoma.

Nguyen TT, Parat MO, Shaw PN, Hewavitharana AK, Hodson MP.

PLoS One. 2016 Feb 1;11(2):e0147956. doi: 10.1371/journal.pone.0147956. eCollection 2016.


Molecular Determinants of the Cellular Entry of Asymmetric Peptide Dendrimers and Role of Caveolae.

Rewatkar PV, Parekh HS, Parat MO.

PLoS One. 2016 Jan 20;11(1):e0147491. doi: 10.1371/journal.pone.0147491. eCollection 2016.


Chemical Characterization and in Vitro Cytotoxicity on Squamous Cell Carcinoma Cells of Carica papaya Leaf Extracts.

Nguyen TT, Parat MO, Hodson MP, Pan J, Shaw PN, Hewavitharana AK.

Toxins (Basel). 2015 Dec 24;8(1). pii: E7. doi: 10.3390/toxins8010007.


Cavin Family: New Players in the Biology of Caveolae.

Nassar ZD, Parat MO.

Int Rev Cell Mol Biol. 2015;320:235-305. doi: 10.1016/bs.ircmb.2015.07.009. Epub 2015 Aug 31. Review.


Non-caveolar caveolin-1 expression in prostate cancer cells promotes lymphangiogenesis.

Nassar ZD, Hill MM, Parton RG, Francois M, Parat MO.

Oncoscience. 2015 Aug 3;2(7):635-45. eCollection 2015.


Morphine Modulates Interleukin-4- or Breast Cancer Cell-induced Pro-metastatic Activation of Macrophages.

Khabbazi S, Goumon Y, Parat MO.

Sci Rep. 2015 Jun 16;5:11389. doi: 10.1038/srep11389.


Diet-induced hypercholesterolemia promotes androgen-independent prostate cancer metastasis via IQGAP1 and caveolin-1.

Moon H, Ruelcke JE, Choi E, Sharpe LJ, Nassar ZD, Bielefeldt-Ohmann H, Parat MO, Shah A, Francois M, Inder KL, Brown AJ, Russell PJ, Parton RG, Hill MM.

Oncotarget. 2015 Apr 10;6(10):7438-53.

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