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Items: 1 to 20 of 197

1.

Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.

Karlsson Linnér R, Biroli P, Kong E, Meddens SFW, Wedow R, Fontana MA, Lebreton M, Tino SP, Abdellaoui A, Hammerschlag AR, Nivard MG, Okbay A, Rietveld CA, Timshel PN, Trzaskowski M, Vlaming R, Zünd CL, Bao Y, Buzdugan L, Caplin AH, Chen CY, Eibich P, Fontanillas P, Gonzalez JR, Joshi PK, Karhunen V, Kleinman A, Levin RZ, Lill CM, Meddens GA, Muntané G, Sanchez-Roige S, Rooij FJV, Taskesen E, Wu Y, Zhang F; 23and Me Research Team; eQTLgen Consortium; International Cannabis Consortium; Social Science Genetic Association Consortium, Auton A, Boardman JD, Clark DW, Conlin A, Dolan CC, Fischbacher U, Groenen PJF, Harris KM, Hasler G, Hofman A, Ikram MA, Jain S, Karlsson R, Kessler RC, Kooyman M, MacKillop J, Männikkö M, Morcillo-Suarez C, McQueen MB, Schmidt KM, Smart MC, Sutter M, Thurik AR, Uitterlinden AG, White J, Wit H, Yang J, Bertram L, Boomsma DI, Esko T, Fehr E, Hinds DA, Johannesson M, Kumari M, Laibson D, Magnusson PKE, Meyer MN, Navarro A, Palmer AA, Pers TH, Posthuma D, Schunk D, Stein MB, Svento R, Tiemeier H, Timmers PRHJ, Turley P, Ursano RJ, Wagner GG, Wilson JF, Gratten J, Lee JJ, Cesarini D, Benjamin DJ, Koellinger PD, Beauchamp JP.

Nat Genet. 2019 Jan 14. doi: 10.1038/s41588-018-0309-3. [Epub ahead of print]

PMID:
30643258
2.

A Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor.

Perez C, Barkley-Levenson AM, Dick B, Glatt PF, Martinez Y, Siegel D, Momper JD, Palmer AA, Cohen SM.

J Med Chem. 2019 Jan 10. doi: 10.1021/acs.jmedchem.8b01868. [Epub ahead of print]

PMID:
30628789
3.

Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry.

Sanchez-Roige S, Fontanillas P, Elson SL; 23andMe Research Team, Pandit A, Schmidt EM, Foerster JR, Abecasis GR, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA.

Nat Neurosci. 2019 Jan 8. doi: 10.1038/s41593-018-0306-y. [Epub ahead of print]

PMID:
30622366
4.

Social and anxiety-like behaviors contribute to nicotine self-administration in adolescent outbred rats.

Wang T, Han W, Chitre AS, Polesskaya O, Solberg Woods LC, Palmer AA, Chen H.

Sci Rep. 2018 Dec 24;8(1):18069. doi: 10.1038/s41598-018-36263-w.

5.

Genome wide association analysis in a mouse advanced intercross line.

Gonzales NM, Seo J, Hernandez Cordero AI, St Pierre CL, Gregory JS, Distler MG, Abney M, Canzar S, Lionikas A, Palmer AA.

Nat Commun. 2018 Dec 4;9(1):5162. doi: 10.1038/s41467-018-07642-8.

6.

Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders.

Walters RK, Polimanti R, Johnson EC, McClintick JN, Adams MJ, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Chou YL, Degenhardt F, Docherty AR, Edwards AC, Fontanillas P, Foo JC, Fox L, Frank J, Giegling I, Gordon S, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Herms S, Hodgkinson C, Hoffmann P, Jan Hottenga J, Kennedy MA, Alanne-Kinnunen M, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Pearson JF, Peterson RE, Ripatti S, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG; 23andMe Research Team, Boardman JD, Chen D, Choi DS, Copeland WE, Culverhouse RC, Dahmen N, Degenhardt L, Domingue BW, Elson SL, Frye MA, Gäbel W, Hayward C, Ising M, Keyes M, Kiefer F, Kramer J, Kuperman S, Lucae S, Lynskey MT, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray AD, Nurnberger JI, Palotie A, Preuss U, Räikkönen K, Reynolds MD, Ridinger M, Scherbaum N, Schuckit MA, Soyka M, Treutlein J, Witt S, Wodarz N, Zill P, Adkins DE, Boden JM, Boomsma DI, Bierut LJ, Brown SA, Bucholz KK, Cichon S, Costello EJ, de Wit H, Diazgranados N, Dick DM, Eriksson JG, Farrer LA, Foroud TM, Gillespie NA, Goate AM, Goldman D, Grucza RA, Hancock DB, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono W, Johnson EO, Kaprio JA, Karpyak VM, Kendler KS, Kranzler HR, Krauter K, Lichtenstein P, Lind PA, McGue M, MacKillop J, Madden PAF, Maes HH, Magnusson P, Martin NG, Medland SE, Montgomery GW, Nelson EC, Nöthen MM, Palmer AA, Pedersen NL, Penninx BWJH, Porjesz B, Rice JP, Rietschel M, Riley BP, Rose R, Rujescu D, Shen PH, Silberg J, Stallings MC, Tarter RE, Vanyukov MM, Vrieze S, Wall TL, Whitfield JB, Zhao H, Neale BM, Gelernter J, Edenberg HJ, Agrawal A.

Nat Neurosci. 2018 Dec;21(12):1656-1669. doi: 10.1038/s41593-018-0275-1. Epub 2018 Nov 26.

PMID:
30482948
7.

Genome-Wide Association Study Meta-Analysis of the Alcohol Use Disorders Identification Test (AUDIT) in Two Population-Based Cohorts.

Sanchez-Roige S, Palmer AA, Fontanillas P, Elson SL; 23andMe Research Team; Substance Use Disorder Working Group of the Psychiatric Genomics Consortium, Adams MJ, Howard DM, Edenberg HJ, Davies G, Crist RC, Deary IJ, McIntosh AM, Clarke TK.

Am J Psychiatry. 2018 Oct 19:appiajp201818040369. doi: 10.1176/appi.ajp.2018.18040369. [Epub ahead of print]

PMID:
30336701
8.

Genetic influences on delayed reward discounting: A genome-wide prioritized subset approach.

MacKillop J, Gray JC, Weafer J, Sanchez-Roige S, Palmer AA, de Wit H.

Exp Clin Psychopharmacol. 2018 Sep 27. doi: 10.1037/pha0000227. [Epub ahead of print]

PMID:
30265060
9.

GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia.

Pasman JA, Verweij KJH, Gerring Z, Stringer S, Sanchez-Roige S, Treur JL, Abdellaoui A, Nivard MG, Baselmans BML, Ong JS, Ip HF, van der Zee MD, Bartels M, Day FR, Fontanillas P, Elson SL; 23andMe Research Team, de Wit H, Davis LK, MacKillop J; Substance Use Disorders Working Group of the Psychiatric Genomics Consortium; International Cannabis Consortium, Derringer JL, Branje SJT, Hartman CA, Heath AC, van Lier PAC, Madden PAF, Mägi R, Meeus W, Montgomery GW, Oldehinkel AJ, Pausova Z, Ramos-Quiroga JA, Paus T, Ribases M, Kaprio J, Boks MPM, Bell JT, Spector TD, Gelernter J, Boomsma DI, Martin NG, MacGregor S, Perry JRB, Palmer AA, Posthuma D, Munafò MR, Gillespie NA, Derks EM, Vink JM.

Nat Neurosci. 2018 Sep;21(9):1161-1170. doi: 10.1038/s41593-018-0206-1. Epub 2018 Aug 27.

PMID:
30150663
10.

Publisher Correction: Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry.

Sanchez-Roige S, Fontanillas P, Elson SL; 23andMe Research Team, Pandit A, Schmidt EM, Foerster JR, Abecasis GR, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA.

Nat Neurosci. 2018 Jul;21(7):1018. doi: 10.1038/s41593-018-0117-1. Erratum in: Nat Neurosci. 2019 Jan 8;:.

PMID:
29752479
11.

Glyoxalase 1 (GLO1) Inhibition or Genetic Overexpression Does Not Alter Ethanol's Locomotor Effects: Implications for GLO1 as a Therapeutic Target in Alcohol Use Disorders.

Barkley-Levenson AM, Lagarda FA, Palmer AA.

Alcohol Clin Exp Res. 2018 May;42(5):869-878. doi: 10.1111/acer.13623. Epub 2018 Apr 18.

PMID:
29532486
12.

Inhibition of Glyoxalase 1 reduces alcohol self-administration in dependent and nondependent rats.

de Guglielmo G, Conlisk DE, Barkley-Levenson AM, Palmer AA, George O.

Pharmacol Biochem Behav. 2018 Apr;167:36-41. doi: 10.1016/j.pbb.2018.03.001. Epub 2018 Mar 2.

PMID:
29505808
13.

Hierarchical investigation of genetic influences on response inhibition in healthy young adults.

Weafer J, Gray JC, Hernandez K, Palmer AA, MacKillop J, de Wit H.

Exp Clin Psychopharmacol. 2017 Dec;25(6):512-520. doi: 10.1037/pha0000156.

14.

Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry.

Sanchez-Roige S, Fontanillas P, Elson SL; 23andMe Research Team, Pandit A, Schmidt EM, Foerster JR, Abecasis GR, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA.

Nat Neurosci. 2018 Jan;21(1):16-18. doi: 10.1038/s41593-017-0032-x. Epub 2017 Dec 11. Erratum in: Nat Neurosci. 2018 May 11;:. Nat Neurosci. 2019 Jan 8;:.

PMID:
29230059
15.

The genetics of human personality.

Sanchez-Roige S, Gray JC, MacKillop J, Chen CH, Palmer AA.

Genes Brain Behav. 2018 Mar;17(3):e12439. doi: 10.1111/gbb.12439. Epub 2017 Dec 29. Review.

PMID:
29152902
16.

Genetic analysis of impulsive personality traits: Examination of a priori candidates and genome-wide variation.

Gray JC, MacKillop J, Weafer J, Hernandez KM, Gao J, Palmer AA, de Wit H.

Psychiatry Res. 2018 Jan;259:398-404. doi: 10.1016/j.psychres.2017.10.047. Epub 2017 Nov 8.

17.

Genome-wide association study of alcohol use disorder identification test (AUDIT) scores in 20 328 research participants of European ancestry.

Sanchez-Roige S, Fontanillas P, Elson SL; 23andMe Research Team, Gray JC, de Wit H, Davis LK, MacKillop J, Palmer AA.

Addict Biol. 2019 Jan;24(1):121-131. doi: 10.1111/adb.12574. Epub 2017 Oct 23.

PMID:
29058377
18.

Heterogeneous stock rats: a model to study the genetics of despair-like behavior in adolescence.

Holl K, He H, Wedemeyer M, Clopton L, Wert S, Meckes JK, Cheng R, Kastner A, Palmer AA, Redei EE, Solberg Woods LC.

Genes Brain Behav. 2018 Feb;17(2):139-148. doi: 10.1111/gbb.12410. Epub 2017 Sep 26.

19.

Impulsivity as a mechanism linking child abuse and neglect with substance use in adolescence and adulthood.

Oshri A, Kogan SM, Kwon JA, Wickrama KAS, Vanderbroek L, Palmer AA, MacKillop J.

Dev Psychopathol. 2018 May;30(2):417-435. doi: 10.1017/S0954579417000943. Epub 2017 Jun 13.

PMID:
28606210
20.

Genetic influences on ADHD symptom dimensions: Examination of a priori candidates, gene-based tests, genome-wide variation, and SNP heritability.

Bidwell LC, Gray JC, Weafer J, Palmer AA, de Wit H, MacKillop J.

Am J Med Genet B Neuropsychiatr Genet. 2017 Jun;174(4):458-466. doi: 10.1002/ajmg.b.32535.

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