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Items: 1 to 20 of 25

1.

Stopped-Flow Kinetic Techniques for Studying Binding Reactions of Intrinsically Disordered Proteins.

Crabtree MD, Shammas SL.

Methods Enzymol. 2018;611:423-457. doi: 10.1016/bs.mie.2018.09.026. Epub 2018 Nov 7.

PMID:
30471695
2.

Two Differential Binding Mechanisms of FG-Nucleoporins and Nuclear Transport Receptors.

Tan PS, Aramburu IV, Mercadante D, Tyagi S, Chowdhury A, Spitz D, Shammas SL, Gräter F, Lemke EA.

Cell Rep. 2018 Mar 27;22(13):3660-3671. doi: 10.1016/j.celrep.2018.03.022.

3.

Hsp70 Inhibits the Nucleation and Elongation of Tau and Sequesters Tau Aggregates with High Affinity.

Kundel F, De S, Flagmeier P, Horrocks MH, Kjaergaard M, Shammas SL, Jackson SE, Dobson CM, Klenerman D.

ACS Chem Biol. 2018 Mar 16;13(3):636-646. doi: 10.1021/acschembio.7b01039. Epub 2018 Jan 17.

4.

pKID Binds to KIX via an Unstructured Transition State with Nonnative Interactions.

Dahal L, Kwan TOC, Shammas SL, Clarke J.

Biophys J. 2017 Dec 19;113(12):2713-2722. doi: 10.1016/j.bpj.2017.10.016.

5.

Phosphorylation of the IDP KID Modulates Affinity for KIX by Increasing the Lifetime of the Complex.

Dahal L, Shammas SL, Clarke J.

Biophys J. 2017 Dec 19;113(12):2706-2712. doi: 10.1016/j.bpj.2017.10.015.

6.

Affinity of IDPs to their targets is modulated by ion-specific changes in kinetics and residual structure.

Wicky BIM, Shammas SL, Clarke J.

Proc Natl Acad Sci U S A. 2017 Sep 12;114(37):9882-9887. doi: 10.1073/pnas.1705105114. Epub 2017 Aug 28.

7.

Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex.

Crabtree MD, Borcherds W, Poosapati A, Shammas SL, Daughdrill GW, Clarke J.

Biochemistry. 2017 May 9;56(18):2379-2384. doi: 10.1021/acs.biochem.7b00179. Epub 2017 Apr 26.

8.

Role of non-native electrostatic interactions in the coupled folding and binding of PUMA with Mcl-1.

Chu WT, Clarke J, Shammas SL, Wang J.

PLoS Comput Biol. 2017 Apr 3;13(4):e1005468. doi: 10.1371/journal.pcbi.1005468. eCollection 2017 Apr.

9.

Mechanistic roles of protein disorder within transcription.

Shammas SL.

Curr Opin Struct Biol. 2017 Feb;42:155-161. doi: 10.1016/j.sbi.2017.02.003. Epub 2017 Mar 4. Review.

10.

GADIS: Algorithm for designing sequences to achieve target secondary structure profiles of intrinsically disordered proteins.

Harmon TS, Crabtree MD, Shammas SL, Posey AE, Clarke J, Pappu RV.

Protein Eng Des Sel. 2016 Sep;29(9):339-46. doi: 10.1093/protein/gzw034. Epub 2016 Aug 8.

11.

Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies.

Shammas SL, Crabtree MD, Dahal L, Wicky BI, Clarke J.

J Biol Chem. 2016 Mar 25;291(13):6689-95. doi: 10.1074/jbc.R115.692715. Epub 2016 Feb 5. Review.

12.

Transient misfolding dominates multidomain protein folding.

Borgia A, Kemplen KR, Borgia MB, Soranno A, Shammas S, Wunderlich B, Nettels D, Best RB, Clarke J, Schuler B.

Nat Commun. 2015 Nov 17;6:8861. doi: 10.1038/ncomms9861.

13.

Plasticity of an ultrafast interaction between nucleoporins and nuclear transport receptors.

Milles S, Mercadante D, Aramburu IV, Jensen MR, Banterle N, Koehler C, Tyagi S, Clarke J, Shammas SL, Blackledge M, Gräter F, Lemke EA.

Cell. 2015 Oct 22;163(3):734-45. doi: 10.1016/j.cell.2015.09.047. Epub 2015 Oct 8.

14.

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers.

Shammas SL, Garcia GA, Kumar S, Kjaergaard M, Horrocks MH, Shivji N, Mandelkow E, Knowles TP, Mandelkow E, Klenerman D.

Nat Commun. 2015 Apr 30;6:7025. doi: 10.1038/ncomms8025.

15.

Interplay between partner and ligand facilitates the folding and binding of an intrinsically disordered protein.

Rogers JM, Oleinikovas V, Shammas SL, Wong CT, De Sancho D, Baker CM, Clarke J.

Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15420-5. doi: 10.1073/pnas.1409122111. Epub 2014 Oct 13.

16.

Allostery within a transcription coactivator is predominantly mediated through dissociation rate constants.

Shammas SL, Travis AJ, Clarke J.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12055-60. doi: 10.1073/pnas.1405815111. Epub 2014 Aug 4.

17.

Mechanism of assembly of the non-covalent spectrin tetramerization domain from intrinsically disordered partners.

Hill SA, Kwa LG, Shammas SL, Lee JC, Clarke J.

J Mol Biol. 2014 Jan 9;426(1):21-35. doi: 10.1016/j.jmb.2013.08.027. Epub 2013 Sep 17.

18.

Remarkably fast coupled folding and binding of the intrinsically disordered transactivation domain of cMyb to CBP KIX.

Shammas SL, Travis AJ, Clarke J.

J Phys Chem B. 2013 Oct 24;117(42):13346-56. doi: 10.1021/jp404267e. Epub 2013 Aug 15.

19.

Slow, reversible, coupled folding and binding of the spectrin tetramerization domain.

Shammas SL, Rogers JM, Hill SA, Clarke J.

Biophys J. 2012 Nov 21;103(10):2203-14. doi: 10.1016/j.bpj.2012.10.012. Epub 2012 Nov 20.

20.

Protein folding: adding a nucleus to guide helix docking reduces landscape roughness.

Wensley BG, Kwa LG, Shammas SL, Rogers JM, Clarke J.

J Mol Biol. 2012 Oct 26;423(3):273-83. doi: 10.1016/j.jmb.2012.08.003. Epub 2012 Aug 20.

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