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Items: 1 to 20 of 437


Disparate Tuberculosis Disease Development in Macaque Species Is Associated With Innate Immunity.

Dijkman K, Vervenne RAW, Sombroek CC, Boot C, Hofman SO, van Meijgaarden KE, Ottenhoff THM, Kocken CHM, Haanstra KG, Vierboom MPM, Verreck FAW.

Front Immunol. 2019 Nov 1;10:2479. doi: 10.3389/fimmu.2019.02479. eCollection 2019.


Abnormalities suggestive of latent tuberculosis infection on chest radiography; how specific are they?

Uzorka JW, Kroft LJM, Bakker JA, van Zwet EW, Huisman E, Prins C, van der Zwan CJ, Ottenhoff THM, Arend SM.

J Clin Tuberc Other Mycobact Dis. 2019 Jan 25;15:100089. doi: 10.1016/j.jctube.2019.01.004. eCollection 2019 May.


Mobilizing unconventional T cells.

Ottenhoff THM, Joosten SA.

Science. 2019 Oct 18;366(6463):302-303. doi: 10.1126/science.aay7079. No abstract available.


Identification of a systemic interferon-γ inducible antimicrobial gene signature in leprosy patients undergoing reversal reaction.

Teles RMB, Lu J, Tió-Coma M, Goulart IMB, Banu S, Hagge D, Bobosha K, Ottenhoff THM, Pellegrini M, Geluk A, Modlin RL.

PLoS Negl Trop Dis. 2019 Oct 10;13(10):e0007764. doi: 10.1371/journal.pntd.0007764. eCollection 2019 Oct.


Guidance for Studies Evaluating the Accuracy of Tuberculosis Triage Tests.

Nathavitharana RR, Yoon C, Macpherson P, Dowdy DW, Cattamanchi A, Somoskovi A, Broger T, Ottenhoff THM, Arinaminpathy N, Lonnroth K, Reither K, Cobelens F, Gilpin C, Denkinger CM, Schumacher SG.

J Infect Dis. 2019 Oct 8;220(Supplement_3):S116-S125. doi: 10.1093/infdis/jiz243.


Effectiveness of Stress-Reducing Interventions on the Response to Challenges to the Immune System: A Meta-Analytic Review.

Schakel L, Veldhuijzen DS, Crompvoets PI, Bosch JA, Cohen S, van Middendorp H, Joosten SA, Ottenhoff THM, Visser LG, Evers AWM.

Psychother Psychosom. 2019;88(5):274-286. doi: 10.1159/000501645. Epub 2019 Aug 6. Review.


Radiological Signs of Latent Tuberculosis on Chest Radiography: A Systematic Review and Meta-Analysis.

Uzorka JW, Wallinga J, Kroft LJM, Ottenhoff THM, Arend SM.

Open Forum Infect Dis. 2019 Jul 1;6(7). pii: ofz313. doi: 10.1093/ofid/ofz313.


Two-Hit in vitro T-Cell Stimulation Detects Mycobacterium tuberculosis Infection in QuantiFERON Negative Tuberculosis Patients and Healthy Contacts From Ghana.

Adankwah E, Lundtoft C, Güler A, Franken KLMC, Ottenhoff THM, Mayatepek E, Owusu-Dabo E, Phillips RO, Nausch N, Jacobsen M.

Front Immunol. 2019 Jul 3;10:1518. doi: 10.3389/fimmu.2019.01518. eCollection 2019.


Whole-blood transcriptomic signatures induced during immunization by chloroquine prophylaxis and Plasmodium falciparum sporozoites.

Tran TM, Bijker EM, Haks MC, Ottenhoff THM, Visser L, Schats R, Venepally P, Lorenzi H, Crompton PD, Sauerwein RW.

Sci Rep. 2019 Jun 10;9(1):8386. doi: 10.1038/s41598-019-44924-7.


Harnessing donor unrestricted T-cells for new vaccines against tuberculosis.

Joosten SA, Ottenhoff THM, Lewinsohn DM, Hoft DF, Moody DB, Seshadri C; Collaboration for Tuberculosis Vaccine Discovery - Donor-Unrestricted T-cells Working Group, Bill and Melinda Gates Foundation.

Vaccine. 2019 May 21;37(23):3022-3030. doi: 10.1016/j.vaccine.2019.04.050. Epub 2019 Apr 27. Review.


Oxidized low-density lipoprotein (oxLDL) supports Mycobacterium tuberculosis survival in macrophages by inducing lysosomal dysfunction.

Vrieling F, Wilson L, Rensen PCN, Walzl G, Ottenhoff THM, Joosten SA.

PLoS Pathog. 2019 Apr 18;15(4):e1007724. doi: 10.1371/journal.ppat.1007724. eCollection 2019 Apr.


Discovery and validation of a prognostic proteomic signature for tuberculosis progression: A prospective cohort study.

Penn-Nicholson A, Hraha T, Thompson EG, Sterling D, Mbandi SK, Wall KM, Fisher M, Suliman S, Shankar S, Hanekom WA, Janjic N, Hatherill M, Kaufmann SHE, Sutherland J, Walzl G, De Groote MA, Ochsner U, Zak DE, Scriba TJ; ACS and GC6–74 cohort study groups.

PLoS Med. 2019 Apr 16;16(4):e1002781. doi: 10.1371/journal.pmed.1002781. eCollection 2019 Apr. Erratum in: PLoS Med. 2019 Jul 18;16(7):e1002880.


Immunometabolic Signatures Predict Risk of Progression to Active Tuberculosis and Disease Outcome.

Duffy FJ, Weiner J 3rd, Hansen S, Tabb DL, Suliman S, Thompson E, Maertzdorf J, Shankar S, Tromp G, Parida S, Dover D, Axthelm MK, Sutherland JS, Dockrell HM, Ottenhoff THM, Scriba TJ, Picker LJ, Walzl G, Kaufmann SHE, Zak DE; GC6-74 Consortium.

Front Immunol. 2019 Mar 22;10:527. doi: 10.3389/fimmu.2019.00527. eCollection 2019.


Evidence for Highly Variable, Region-Specific Patterns of T-Cell Epitope Mutations Accumulating in Mycobacterium tuberculosis Strains.

Ramaiah A, Nayak S, Rakshit S, Manson AL, Abeel T, Shanmugam S, Sahoo PN, John AJUK, Sundaramurthi JC, Narayanan S, D'Souza G, von Hoegen P, Ottenhoff THM, Swaminathan S, Earl AM, Vyakarnam A.

Front Immunol. 2019 Feb 13;10:195. doi: 10.3389/fimmu.2019.00195. eCollection 2019.


Optimisation, harmonisation and standardisation of the direct mycobacterial growth inhibition assay using cryopreserved human peripheral blood mononuclear cells.

Tanner R, Smith SG, van Meijgaarden KE, Giannoni F, Wilkie M, Gabriele L, Palma C, Dockrell HM, Ottenhoff THM, McShane H.

J Immunol Methods. 2019 Jun;469:1-10. doi: 10.1016/j.jim.2019.01.006. Epub 2019 Jan 31.


Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques.

Dijkman K, Sombroek CC, Vervenne RAW, Hofman SO, Boot C, Remarque EJ, Kocken CHM, Ottenhoff THM, Kondova I, Khayum MA, Haanstra KG, Vierboom MPM, Verreck FAW.

Nat Med. 2019 Feb;25(2):255-262. doi: 10.1038/s41591-018-0319-9. Epub 2019 Jan 21.


Atypical Human Effector/Memory CD4+ T Cells With a Naive-Like Phenotype.

Caccamo N, Joosten SA, Ottenhoff THM, Dieli F.

Front Immunol. 2018 Dec 3;9:2832. doi: 10.3389/fimmu.2018.02832. eCollection 2018. Review.


Metabolite changes in blood predict the onset of tuberculosis.

Weiner J 3rd, Maertzdorf J, Sutherland JS, Duffy FJ, Thompson E, Suliman S, McEwen G, Thiel B, Parida SK, Zyla J, Hanekom WA, Mohney RP, Boom WH, Mayanja-Kizza H, Howe R, Dockrell HM, Ottenhoff THM, Scriba TJ, Zak DE, Walzl G, Kaufmann SHE; GC6-74 consortium.

Nat Commun. 2018 Dec 6;9(1):5208. doi: 10.1038/s41467-018-07635-7.


A Systematic Review on Novel Mycobacterium tuberculosis Antigens and Their Discriminatory Potential for the Diagnosis of Latent and Active Tuberculosis.

Meier NR, Jacobsen M, Ottenhoff THM, Ritz N.

Front Immunol. 2018 Nov 9;9:2476. doi: 10.3389/fimmu.2018.02476. eCollection 2018.


NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification.

Barruet E, Morales BM, Cain CJ, Ton AN, Wentworth KL, Chan TV, Moody TA, Haks MC, Ottenhoff TH, Hellman J, Nakamura MC, Hsiao EC.

JCI Insight. 2018 Nov 15;3(22). pii: 122958. doi: 10.1172/jci.insight.122958.

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