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Items: 1 to 20 of 55

1.

TGF-β1 Decreases β2-Agonist-Induced Relaxation in Human Airway Smooth Muscle.

Ojiaku CA, Chung E, Parikh V, Williams JK, Schwab A, Fuentes AL, Corpuz ML, Lui V, Paek S, Bexiga NM, Narayan S, Nunez FJ, Ahn K, Ostrom RS, An SS, Panettieri RA Jr.

Am J Respir Cell Mol Biol. 2019 Feb 11. doi: 10.1165/rcmb.2018-0301OC. [Epub ahead of print]

PMID:
30742476
2.

p53 Expression in Lung Fibroblasts Is Linked to Mitigation of Fibrotic Lung Remodeling.

Nagaraja MR, Tiwari N, Shetty SK, Marudamuthu AS, Fan L, Ostrom RS, Fu J, Gopu V, Radhakrishnan V, Idell S, Shetty S.

Am J Pathol. 2018 Oct;188(10):2207-2222. doi: 10.1016/j.ajpath.2018.07.005.

PMID:
30253845
3.

cAMP attenuates TGF-β's profibrotic responses in osteoarthritic synoviocytes: involvement of hyaluronan and PRG4.

Qadri MM, Jay GD, Ostrom RS, Zhang LX, Elsaid KA.

Am J Physiol Cell Physiol. 2018 Sep 1;315(3):C432-C443. doi: 10.1152/ajpcell.00041.2018. Epub 2018 Jun 13.

PMID:
29898378
4.

PDE8 Is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β2-Adrenergic Receptors and Adenylyl Cyclase 6.

Johnstone TB, Smith KH, Koziol-White CJ, Li F, Kazarian AG, Corpuz ML, Shumyatcher M, Ehlert FJ, Himes BE, Panettieri RA Jr, Ostrom RS.

Am J Respir Cell Mol Biol. 2018 Apr;58(4):530-541. doi: 10.1165/rcmb.2017-0294OC.

5.

cAMP Signaling Compartmentation: Adenylyl Cyclases as Anchors of Dynamic Signaling Complexes.

Johnstone TB, Agarwal SR, Harvey RD, Ostrom RS.

Mol Pharmacol. 2018 Apr;93(4):270-276. doi: 10.1124/mol.117.110825. Epub 2017 Dec 7.

PMID:
29217670
6.

Suppression of CHRN endocytosis by carbonic anhydrase CAR3 in the pathogenesis of myasthenia gravis.

Du A, Huang S, Zhao X, Feng K, Zhang S, Huang J, Miao X, Baggi F, Ostrom RS, Zhang Y, Chen X, Xu C.

Autophagy. 2017;13(11):1981-1994. doi: 10.1080/15548627.2017.1375633. Epub 2017 Sep 29.

7.

Hsp90 inhibitor induces nuclear translocation of HSF1 predominantly in hippocampal CA1 region.

Wang B, Liu Y, Huang L, Chen J, Li JJ, Wang R, Kim E, Chen Y, Justicia C, Sakata K, Chen H, Planas A, Ostrom RS, Li W, Yang G, McDonald MP, Chen R, Heck DH, Liao FF.

Mol Psychiatry. 2017 Jul;22(7):935. doi: 10.1038/mp.2017.125. No abstract available.

PMID:
28638149
8.

Compartmentalized cAMP responses to prostaglandin EP2 receptor activation in human airway smooth muscle cells.

Agarwal SR, Miyashiro K, Latt H, Ostrom RS, Harvey RD.

Br J Pharmacol. 2017 Aug;174(16):2784-2796. doi: 10.1111/bph.13904. Epub 2017 Jul 12.

9.

International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases.

Dessauer CW, Watts VJ, Ostrom RS, Conti M, Dove S, Seifert R.

Pharmacol Rev. 2017 Apr;69(2):93-139. doi: 10.1124/pr.116.013078. Review.

10.

A CNS-permeable Hsp90 inhibitor rescues synaptic dysfunction and memory loss in APP-overexpressing Alzheimer's mouse model via an HSF1-mediated mechanism.

Wang B, Liu Y, Huang L, Chen J, Li JJ, Wang R, Kim E, Chen Y, Justicia C, Sakata K, Chen H, Planas A, Ostrom RS, Li W, Yang G, McDonald MP, Chen R, Heck DH, Liao FF.

Mol Psychiatry. 2017 Jul;22(7):990-1001. doi: 10.1038/mp.2016.104. Epub 2016 Jul 26.

11.
12.

A new molecular target for blunting organ fibrosis. Focus on "Secreted Frizzled-related protein 2 as a target in antifibrotic therapeutic intervention".

Ostrom RS.

Am J Physiol Cell Physiol. 2014 Mar 15;306(6):C527-8. doi: 10.1152/ajpcell.00020.2014. Epub 2014 Jan 22. No abstract available.

13.

Non-raft adenylyl cyclase 2 defines a cAMP signaling compartment that selectively regulates IL-6 expression in airway smooth muscle cells: differential regulation of gene expression by AC isoforms.

Bogard AS, Birg AV, Ostrom RS.

Naunyn Schmiedebergs Arch Pharmacol. 2014 Apr;387(4):329-39. doi: 10.1007/s00210-013-0950-4. Epub 2013 Dec 22.

14.

Adenylyl cyclase 6 activation negatively regulates TLR4 signaling through lipid raft-mediated endocytosis.

Cai W, Du A, Feng K, Zhao X, Qian L, Ostrom RS, Xu C.

J Immunol. 2013 Dec 15;191(12):6093-100. doi: 10.4049/jimmunol.1301912. Epub 2013 Nov 11.

15.

Development of a high-throughput screening paradigm for the discovery of small-molecule modulators of adenylyl cyclase: identification of an adenylyl cyclase 2 inhibitor.

Conley JM, Brand CS, Bogard AS, Pratt EP, Xu R, Hockerman GH, Ostrom RS, Dessauer CW, Watts VJ.

J Pharmacol Exp Ther. 2013 Nov;347(2):276-87. doi: 10.1124/jpet.113.207449. Epub 2013 Sep 5.

16.

Adenylyl cyclase 2 selectively couples to E prostanoid type 2 receptors, whereas adenylyl cyclase 3 is not receptor-regulated in airway smooth muscle.

Bogard AS, Adris P, Ostrom RS.

J Pharmacol Exp Ther. 2012 Aug;342(2):586-95. doi: 10.1124/jpet.112.193425. Epub 2012 May 22.

17.

Melatonin membrane receptors in peripheral tissues: distribution and functions.

Slominski RM, Reiter RJ, Schlabritz-Loutsevitch N, Ostrom RS, Slominski AT.

Mol Cell Endocrinol. 2012 Apr 4;351(2):152-66. doi: 10.1016/j.mce.2012.01.004. Epub 2012 Jan 8. Review.

18.

Choreographing the adenylyl cyclase signalosome: sorting out the partners and the steps.

Ostrom RS, Bogard AS, Gros R, Feldman RD.

Naunyn Schmiedebergs Arch Pharmacol. 2012 Jan;385(1):5-12. doi: 10.1007/s00210-011-0696-9. Epub 2011 Oct 20. Review.

19.

Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains.

Bogard AS, Xu C, Ostrom RS.

J Pharmacol Exp Ther. 2011 Apr;337(1):209-17. doi: 10.1124/jpet.110.177923. Epub 2011 Jan 12.

20.

The M2-muscarinic receptor inhibits the development of streptozotocin-induced neuropathy in mouse urinary bladder.

Pak KJ, Ostrom RS, Matsui M, Ehlert FJ.

J Pharmacol Exp Ther. 2010 Oct;335(1):239-48. doi: 10.1124/jpet.110.169995. Epub 2010 Jul 12.

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