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Items: 1 to 20 of 61

1.

Development of Hybrid Phospholipid Mimics as Effective Agonists for Liver Receptor Homologue-1.

Flynn AR, Mays SG, Ortlund EA, Jui NT.

ACS Med Chem Lett. 2018 Sep 4;9(10):1051-1056. doi: 10.1021/acsmedchemlett.8b00361. eCollection 2018 Oct 11.

PMID:
30344916
2.

High-resolution plasma metabolomics analysis to detect Mycobacterium tuberculosis-associated metabolites that distinguish active pulmonary tuberculosis in humans.

Collins JM, Walker DI, Jones DP, Tukvadze N, Liu KH, Tran VT, Uppal K, Frediani JK, Easley KA, Shenvi N, Khadka M, Ortlund EA, Kempker RR, Blumberg HM, Ziegler TR.

PLoS One. 2018 Oct 11;13(10):e0205398. doi: 10.1371/journal.pone.0205398. eCollection 2018.

3.
4.

The nuclear receptor superfamily: A structural perspective.

Weikum ER, Liu X, Ortlund EA.

Protein Sci. 2018 Nov;27(11):1876-1892. doi: 10.1002/pro.3496. Review.

PMID:
30109749
5.

Delimiting the autoinhibitory module of von Willebrand factor.

Deng W, Voos KM, Colucci JK, Legan ER, Ortlund EA, Lollar P, Li R.

J Thromb Haemost. 2018 Oct;16(10):2097-2105. doi: 10.1111/jth.14251. Epub 2018 Aug 16.

PMID:
30053340
6.

Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.

Mandal P, Feng Y, Lyons JD, Berger SB, Otani S, DeLaney A, Tharp GK, Maner-Smith K, Burd EM, Schaeffer M, Hoffman S, Capriotti C, Roback L, Young CB, Liang Z, Ortlund EA, DiPaolo NC, Bosinger S, Bertin J, Gough PJ, Brodsky IE, Coopersmith CM, Shayakhmetov DM, Mocarski ES.

Immunity. 2018 Jul 17;49(1):42-55.e6. doi: 10.1016/j.immuni.2018.06.011.

PMID:
30021146
7.

Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements.

Hudson WH, Vera IMS, Nwachukwu JC, Weikum ER, Herbst AG, Yang Q, Bain DL, Nettles KW, Kojetin DJ, Ortlund EA.

Nat Commun. 2018 Apr 6;9(1):1337. doi: 10.1038/s41467-018-03780-1.

8.

Structural and Dynamics Comparison of Thermostability in Ancient, Modern, and Consensus Elongation Factor Tus.

Okafor CD, Pathak MC, Fagan CE, Bauer NC, Cole MF, Gaucher EA, Ortlund EA.

Structure. 2018 Jan 2;26(1):118-129.e3. doi: 10.1016/j.str.2017.11.018. Epub 2017 Dec 21.

PMID:
29276038
9.

Nucleotide Binding to ARL2 in the TBCD∙ARL2∙β-Tubulin Complex Drives Conformational Changes in β-Tubulin.

Francis JW, Goswami D, Novick SJ, Pascal BD, Weikum ER, Ortlund EA, Griffin PR, Kahn RA.

J Mol Biol. 2017 Nov 24;429(23):3696-3716. doi: 10.1016/j.jmb.2017.09.016. Epub 2017 Sep 29.

PMID:
28970104
10.

Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes.

Weikum ER, de Vera IMS, Nwachukwu JC, Hudson WH, Nettles KW, Kojetin DJ, Ortlund EA.

Nucleic Acids Res. 2017 Aug 21;45(14):8596-8608. doi: 10.1093/nar/gkx509.

11.

Structural Analysis of the Glucocorticoid Receptor Ligand-Binding Domain in Complex with Triamcinolone Acetonide and a Fragment of the Atypical Coregulator, Small Heterodimer Partner.

Weikum ER, Okafor CD, D'Agostino EH, Colucci JK, Ortlund EA.

Mol Pharmacol. 2017 Jul;92(1):12-21. doi: 10.1124/mol.117.108506. Epub 2017 Apr 10.

12.

Structure and Dynamics of the Liver Receptor Homolog 1-PGC1α Complex.

Mays SG, Okafor CD, Tuntland ML, Whitby RJ, Dharmarajan V, Stec J, Griffin PR, Ortlund EA.

Mol Pharmacol. 2017 Jul;92(1):1-11. doi: 10.1124/mol.117.108514. Epub 2017 Mar 31.

13.

Glucocorticoid receptor control of transcription: precision and plasticity via allostery.

Weikum ER, Knuesel MT, Ortlund EA, Yamamoto KR.

Nat Rev Mol Cell Biol. 2017 Mar;18(3):159-174. doi: 10.1038/nrm.2016.152. Epub 2017 Jan 5. Review.

PMID:
28053348
14.

A Structural Investigation into Oct4 Regulation by Orphan Nuclear Receptors, Germ Cell Nuclear Factor (GCNF), and Liver Receptor Homolog-1 (LRH-1).

Weikum ER, Tuntland ML, Murphy MN, Ortlund EA.

J Mol Biol. 2016 Dec 4;428(24 Pt B):4981-4992. doi: 10.1016/j.jmb.2016.10.025. Epub 2016 Oct 27.

15.

Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists.

Mays SG, Okafor CD, Whitby RJ, Goswami D, Stec J, Flynn AR, Dugan MC, Jui NT, Griffin PR, Ortlund EA.

J Biol Chem. 2016 Dec 2;291(49):25281-25291. Epub 2016 Sep 30.

16.

Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.

Hudson WH, Kossmann BR, de Vera IM, Chuo SW, Weikum ER, Eick GN, Thornton JW, Ivanov IN, Kojetin DJ, Ortlund EA.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):326-31. doi: 10.1073/pnas.1518960113. Epub 2015 Dec 29.

17.

Unexpected Allosteric Network Contributes to LRH-1 Co-regulator Selectivity.

Musille PM, Kossmann BR, Kohn JA, Ivanov I, Ortlund EA.

J Biol Chem. 2016 Jan 15;291(3):1411-26. doi: 10.1074/jbc.M115.662874. Epub 2015 Nov 9.

18.

Identification of a lipid scrambling domain in ANO6/TMEM16F.

Yu K, Whitlock JM, Lee K, Ortlund EA, Cui YY, Hartzell HC.

Elife. 2015 Jun 9;4:e06901. doi: 10.7554/eLife.06901.

19.

Integration of G protein α (Gα) signaling by the regulator of G protein signaling 14 (RGS14).

Brown NE, Goswami D, Branch MR, Ramineni S, Ortlund EA, Griffin PR, Hepler JR.

J Biol Chem. 2015 Apr 3;290(14):9037-49. doi: 10.1074/jbc.M114.634329. Epub 2015 Feb 9.

20.

Aging. Lysosomal signaling molecules regulate longevity in Caenorhabditis elegans.

Folick A, Oakley HD, Yu Y, Armstrong EH, Kumari M, Sanor L, Moore DD, Ortlund EA, Zechner R, Wang MC.

Science. 2015 Jan 2;347(6217):83-6. doi: 10.1126/science.1258857.

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