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Items: 1 to 20 of 71


Spontaneous DNA damage to the nuclear genome promotes senescence, redox imbalance and aging.

Robinson AR, Yousefzadeh MJ, Rozgaja TA, Wang J, Li X, Tilstra JS, Feldman CH, Gregg SQ, Johnson CH, Skoda EM, Frantz MC, Bell-Temin H, Pope-Varsalona H, Gurkar AU, Nasto LA, Robinson RAS, Fuhrmann-Stroissnigg H, Czerwinska J, McGowan SJ, Cantu-Medellin N, Harris JB, Maniar S, Ross MA, Trussoni CE, LaRusso NF, Cifuentes-Pagano E, Pagano PJ, Tudek B, Vo NV, Rigatti LH, Opresko PL, Stolz DB, Watkins SC, Burd CE, Croix CMS, Siuzdak G, Yates NA, Robbins PD, Wang Y, Wipf P, Kelley EE, Niedernhofer LJ.

Redox Biol. 2018 Jul;17:259-273. doi: 10.1016/j.redox.2018.04.007. Epub 2018 Apr 13.


The impact of oxidative DNA damage and stress on telomere homeostasis.

Barnes RP, Fouquerel E, Opresko PL.

Mech Ageing Dev. 2019 Jan;177:37-45. doi: 10.1016/j.mad.2018.03.013. Epub 2018 Mar 28. Review.


Leukocyte telomere length in relation to risk of lung adenocarcinoma incidence: Findings from the Singapore Chinese Health Study.

Yuan JM, Beckman KB, Wang R, Bull C, Adams-Haduch J, Huang JY, Jin A, Opresko P, Newman AB, Zheng YL, Fenech M, Koh WP.

Int J Cancer. 2018 Jun 1;142(11):2234-2243. doi: 10.1002/ijc.31251. Epub 2018 Jan 25.


γPNA FRET Pair Miniprobes for Quantitative Fluorescent In Situ Hybridization to Telomeric DNA in Cells and Tissue.

Orenstein A, Berlyoung AS, Rastede EE, Pham HH, Fouquerel E, Murphy CT, Leibowitz BJ, Yu J, Srivastava T, Armitage BA, Opresko PL.

Molecules. 2017 Dec 2;22(12). pii: E2117. doi: 10.3390/molecules22122117.


Molecular mechanisms by which oxidative DNA damage promotes telomerase activity.

Lee HT, Bose A, Lee CY, Opresko PL, Myong S.

Nucleic Acids Res. 2017 Nov 16;45(20):11752-11765. doi: 10.1093/nar/gkx789.


NEIL3 Repairs Telomere Damage during S Phase to Secure Chromosome Segregation at Mitosis.

Zhou J, Chan J, Lambelé M, Yusufzai T, Stumpff J, Opresko PL, Thali M, Wallace SS.

Cell Rep. 2017 Aug 29;20(9):2044-2056. doi: 10.1016/j.celrep.2017.08.020.


Modified Terminal Restriction Fragment Analysis for Quantifying Telomere Length Using In-gel Hybridization.

Jenkins FJ, Kerr CM, Fouquerel E, Bovbjerg DH, Opresko PL.

J Vis Exp. 2017 Jul 10;(125). doi: 10.3791/56001.


Convergence of The Nobel Fields of Telomere Biology and DNA Repair.

Fouquerel E, Opresko PL.

Photochem Photobiol. 2017 Jan;93(1):229-237. doi: 10.1111/php.12672. Epub 2017 Jan 30. Review.


Proteomic Profiling Reveals a Specific Role for Translesion DNA Polymerase η in the Alternative Lengthening of Telomeres.

Garcia-Exposito L, Bournique E, Bergoglio V, Bose A, Barroso-Gonzalez J, Zhang S, Roncaioli JL, Lee M, Wallace CT, Watkins SC, Opresko PL, Hoffmann JS, O'Sullivan RJ.

Cell Rep. 2016 Nov 8;17(7):1858-1871. doi: 10.1016/j.celrep.2016.10.048.


Oxidative guanine base damage regulates human telomerase activity.

Fouquerel E, Lormand J, Bose A, Lee HT, Kim GS, Li J, Sobol RW, Freudenthal BD, Myong S, Opresko PL.

Nat Struct Mol Biol. 2016 Dec;23(12):1092-1100. doi: 10.1038/nsmb.3319. Epub 2016 Nov 7.


Single-molecule imaging reveals a common mechanism shared by G-quadruplex-resolving helicases.

Tippana R, Hwang H, Opresko PL, Bohr VA, Myong S.

Proc Natl Acad Sci U S A. 2016 Jul 26;113(30):8448-53. doi: 10.1073/pnas.1603724113. Epub 2016 Jul 12.


Functional interplay between SA1 and TRF1 in telomeric DNA binding and DNA-DNA pairing.

Lin J, Countryman P, Chen H, Pan H, Fan Y, Jiang Y, Kaur P, Miao W, Gurgel G, You C, Piehler J, Kad NM, Riehn R, Opresko PL, Smith S, Tao YJ, Wang H.

Nucleic Acids Res. 2016 Jul 27;44(13):6363-76. doi: 10.1093/nar/gkw518. Epub 2016 Jun 13.


DNA damage processing at telomeres: The ends justify the means.

Fouquerel E, Parikh D, Opresko P.

DNA Repair (Amst). 2016 Aug;44:159-168. doi: 10.1016/j.dnarep.2016.05.022. Epub 2016 May 16. Review.


Telomere-associated aging disorders.

Opresko PL, Shay JW.

Ageing Res Rev. 2017 Jan;33:52-66. doi: 10.1016/j.arr.2016.05.009. Epub 2016 May 20. Review.


Association of TERT promoter mutations with telomerase expression in melanoma.

Lee S, Opresko P, Pappo A, Kirkwood JM, Bahrami A.

Pigment Cell Melanoma Res. 2016 May;29(3):391-3. doi: 10.1111/pcmr.12471. No abstract available.


Enhanced electrostatic force microscopy reveals higher-order DNA looping mediated by the telomeric protein TRF2.

Kaur P, Wu D, Lin J, Countryman P, Bradford KC, Erie DA, Riehn R, Opresko PL, Wang H.

Sci Rep. 2016 Feb 9;6:20513. doi: 10.1038/srep20513.


Telomeres are partly shielded from ultraviolet-induced damage and proficient for nucleotide excision repair of photoproducts.

Parikh D, Fouquerel E, Murphy CT, Wang H, Opresko PL.

Nat Commun. 2015 Sep 9;6:8214. doi: 10.1038/ncomms9214.


Polymerase η suppresses telomere defects induced by DNA damaging agents.

Pope-Varsalona H, Liu FJ, Guzik L, Opresko PL.

Nucleic Acids Res. 2014 Dec 1;42(21):13096-109. doi: 10.1093/nar/gku1030. Epub 2014 Oct 29.


Single-molecule real-time detection of telomerase extension activity.

Hwang H, Opresko P, Myong S.

Sci Rep. 2014 Sep 29;4:6391. doi: 10.1038/srep06391.


Cooperative hybridization of γPNA miniprobes to a repeating sequence motif and application to telomere analysis.

Pham HH, Murphy CT, Sureshkumar G, Ly DH, Opresko PL, Armitage BA.

Org Biomol Chem. 2014 Oct 7;12(37):7345-7354. doi: 10.1039/c4ob00953c.

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