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Items: 1 to 20 of 43


The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis.

Bersuker K, Hendricks JM, Li Z, Magtanong L, Ford B, Tang PH, Roberts MA, Tong B, Maimone TJ, Zoncu R, Bassik MC, Nomura DK, Dixon SJ, Olzmann JA.

Nature. 2019 Oct 21. doi: 10.1038/s41586-019-1705-2. [Epub ahead of print]


Covalent targeting of the vacuolar H+-ATPase activates autophagy via mTORC1 inhibition.

Chung CY, Shin HR, Berdan CA, Ford B, Ward CC, Olzmann JA, Zoncu R, Nomura DK.

Nat Chem Biol. 2019 Aug;15(8):776-785. doi: 10.1038/s41589-019-0308-4. Epub 2019 Jul 8.


A Tense Situation: Maintaining ER Homeostasis during Lipid Droplet Budding.

Morris SNS, Olzmann JA.

Dev Cell. 2019 Jul 1;50(1):1-2. doi: 10.1016/j.devcel.2019.06.005.


Harnessing the anti-cancer natural product nimbolide for targeted protein degradation.

Spradlin JN, Hu X, Ward CC, Brittain SM, Jones MD, Ou L, To M, Proudfoot A, Ornelas E, Woldegiorgis M, Olzmann JA, Bussiere DE, Thomas JR, Tallarico JA, McKenna JM, Schirle M, Maimone TJ, Nomura DK.

Nat Chem Biol. 2019 Jul;15(7):747-755. doi: 10.1038/s41589-019-0304-8. Epub 2019 Jun 17.


Identification of Lipid Droplet Proteomes by Proximity Labeling Proteomics Using APEX2.

Bersuker K, Olzmann JA.

Methods Mol Biol. 2019;2008:57-72. doi: 10.1007/978-1-4939-9537-0_5.


Parthenolide Covalently Targets and Inhibits Focal Adhesion Kinase in Breast Cancer Cells.

Berdan CA, Ho R, Lehtola HS, To M, Hu X, Huffman TR, Petri Y, Altobelli CR, Demeulenaere SG, Olzmann JA, Maimone TJ, Nomura DK.

Cell Chem Biol. 2019 Jul 18;26(7):1027-1035.e22. doi: 10.1016/j.chembiol.2019.03.016. Epub 2019 May 9.


Getting a handle on lipid droplets: Insights into ER-lipid droplet tethering.

Nguyen TB, Olzmann JA.

J Cell Biol. 2019 Apr 1;218(4):1089-1091. doi: 10.1083/jcb.201902160. Epub 2019 Mar 18.


Exogenous Monounsaturated Fatty Acids Promote a Ferroptosis-Resistant Cell State.

Magtanong L, Ko PJ, To M, Cao JY, Forcina GC, Tarangelo A, Ward CC, Cho K, Patti GJ, Nomura DK, Olzmann JA, Dixon SJ.

Cell Chem Biol. 2019 Mar 21;26(3):420-432.e9. doi: 10.1016/j.chembiol.2018.11.016. Epub 2019 Jan 24.


Dynamics and functions of lipid droplets.

Olzmann JA, Carvalho P.

Nat Rev Mol Cell Biol. 2019 Mar;20(3):137-155. doi: 10.1038/s41580-018-0085-z. Review.


A Proteomic Map to Navigate Subcellular Reorganization in Fatty Liver Disease.

Li Z, Olzmann JA.

Dev Cell. 2018 Oct 22;47(2):139-141. doi: 10.1016/j.devcel.2018.10.006.


In Close Proximity: The Lipid Droplet Proteome and Crosstalk With the Endoplasmic Reticulum.

Bersuker K, Olzmann JA.

Contact (Thousand Oaks). 2018 Jan-Dec;1. doi: 10.1177/2515256418768996. Epub 2018 Apr 3.


A VCP inhibitor substrate trapping approach (VISTA) enables proteomic profiling of endogenous ERAD substrates.

Huang EY, To M, Tran E, Dionisio LTA, Cho HJ, Baney KLM, Pataki CI, Olzmann JA.

Mol Biol Cell. 2018 May 1;29(9):1021-1030. doi: 10.1091/mbc.E17-08-0514. Epub 2018 Mar 22.


A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes.

Bersuker K, Peterson CWH, To M, Sahl SJ, Savikhin V, Grossman EA, Nomura DK, Olzmann JA.

Dev Cell. 2018 Jan 8;44(1):97-112.e7. doi: 10.1016/j.devcel.2017.11.020. Epub 2017 Dec 21.


Chemoproteomics-Enabled Covalent Ligand Screening Reveals a Thioredoxin-Caspase 3 Interaction Disruptor That Impairs Breast Cancer Pathogenicity.

Anderson KE, To M, Olzmann JA, Nomura DK.

ACS Chem Biol. 2017 Oct 20;12(10):2522-2528. doi: 10.1021/acschembio.7b00711. Epub 2017 Sep 13.


Lipid droplets and lipotoxicity during autophagy.

Nguyen TB, Olzmann JA.

Autophagy. 2017;13(11):2002-2003. doi: 10.1080/15548627.2017.1359451. Epub 2017 Sep 21.


DGAT1-Dependent Lipid Droplet Biogenesis Protects Mitochondrial Function during Starvation-Induced Autophagy.

Nguyen TB, Louie SM, Daniele JR, Tran Q, Dillin A, Zoncu R, Nomura DK, Olzmann JA.

Dev Cell. 2017 Jul 10;42(1):9-21.e5. doi: 10.1016/j.devcel.2017.06.003.


Establishing the lipid droplet proteome: Mechanisms of lipid droplet protein targeting and degradation.

Bersuker K, Olzmann JA.

Biochim Biophys Acta Mol Cell Biol Lipids. 2017 Oct;1862(10 Pt B):1166-1177. doi: 10.1016/j.bbalip.2017.06.006. Epub 2017 Jun 13. Review.


Characterization of protein complexes of the endoplasmic reticulum-associated degradation E3 ubiquitin ligase Hrd1.

Hwang J, Walczak CP, Shaler TA, Olzmann JA, Zhang L, Elias JE, Kopito RR.

J Biol Chem. 2017 Jun 2;292(22):9104-9116. doi: 10.1074/jbc.M117.785055. Epub 2017 Apr 14.


Chemoproteomics-enabled covalent ligand screen reveals a cysteine hotspot in reticulon 4 that impairs ER morphology and cancer pathogenicity.

Bateman LA, Nguyen TB, Roberts AM, Miyamoto DK, Ku WM, Huffman TR, Petri Y, Heslin MJ, Contreras CM, Skibola CF, Olzmann JA, Nomura DK.

Chem Commun (Camb). 2017 Jun 29;53(53):7234-7237. doi: 10.1039/c7cc01480e.


Lipid disequilibrium disrupts ER proteostasis by impairing ERAD substrate glycan trimming and dislocation.

To M, Peterson CW, Roberts MA, Counihan JL, Wu TT, Forster MS, Nomura DK, Olzmann JA.

Mol Biol Cell. 2017 Jan 15;28(2):270-284. doi: 10.1091/mbc.E16-07-0483. Epub 2016 Nov 23.

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