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Items: 1 to 20 of 26


Expansion of human primary hepatocytes in vitro through their amplification as liver progenitors in a 3D organoid system.

Garnier D, Li R, Delbos F, Fourrier A, Collet C, Guguen-Guillouzo C, Chesné C, Nguyen TH.

Sci Rep. 2018 May 29;8(1):8222. doi: 10.1038/s41598-018-26584-1.


Generation of Immunodeficient Rats With Rag1 and Il2rg Gene Deletions and Human Tissue Grafting Models.

Ménoret S, Ouisse LH, Tesson L, Delbos F, Garnier D, Remy S, Usal C, Concordet JP, Giovannangeli C, Chenouard V, Brusselle L, Merieau E, Nerrière-Daguin V, Duteille F, Bellier-Waast F, Fraichard A, Nguyen TH, Anegon I.

Transplantation. 2018 Aug;102(8):1271-1278. doi: 10.1097/TP.0000000000002251.


Multiplex CRISPR/Cas9 system impairs HCMV replication by excising an essential viral gene.

Gergen J, Coulon F, Creneguy A, Elain-Duret N, Gutierrez A, Pinkenburg O, Verhoeyen E, Anegon I, Nguyen TH, Halary FA, Haspot F.

PLoS One. 2018 Feb 15;13(2):e0192602. doi: 10.1371/journal.pone.0192602. eCollection 2018.


Generation of gene-edited rats by delivery of CRISPR/Cas9 protein and donor DNA into intact zygotes using electroporation.

Remy S, Chenouard V, Tesson L, Usal C, Ménoret S, Brusselle L, Heslan JM, Nguyen TH, Bellien J, Merot J, De Cian A, Giovannangeli C, Concordet JP, Anegon I.

Sci Rep. 2017 Nov 29;7(1):16554. doi: 10.1038/s41598-017-16328-y.


21st Nantes Actualités Transplantation: "When Stem Cells Meet Immunology".

Anegon I, Nguyen TH.

Transplantation. 2017 Jan;101(1):12-16. doi: 10.1097/TP.0000000000001476.


Rapid and reliable diagnosis of Wilson disease using X-ray fluorescence.

Kaščáková S, Kewish CM, Rouzière S, Schmitt F, Sobesky R, Poupon J, Sandt C, Francou B, Somogyi A, Samuel D, Jacquemin E, Dubart-Kupperschmitt A, Nguyen TH, Bazin D, Duclos-Vallée JC, Guettier C, Le Naour F.

J Pathol Clin Res. 2016 Jun 6;2(3):175-86. doi: 10.1002/cjp2.48. eCollection 2016 Jul.


A Rapid and Cost-Effective Method for Genotyping Genome-Edited Animals: A Heteroduplex Mobility Assay Using Microfluidic Capillary Electrophoresis.

Chenouard V, Brusselle L, Heslan JM, Remy S, Ménoret S, Usal C, Ouisse LH, NGuyen TH, Anegon I, Tesson L.

J Genet Genomics. 2016 May 20;43(5):341-8. doi: 10.1016/j.jgg.2016.04.005. Epub 2016 May 4.


Successful correction of hemophilia by CRISPR/Cas9 genome editing in vivo: delivery vector and immune responses are the key to success.

Nguyen TH, Anegon I.

EMBO Mol Med. 2016 May 2;8(5):439-41. doi: 10.15252/emmm.201606325. Print 2016 May. No abstract available.


"My Life Needs Editing" (Mort Sahl) and Genome Editing Needs Ethics.

Anegon I, Nguyen TH.

Curr Gene Ther. 2016;16(1):1-2. No abstract available.


Highly efficient in vitro and in vivo delivery of functional RNAs using new versatile MS2-chimeric retrovirus-like particles.

Prel A, Caval V, Gayon R, Ravassard P, Duthoit C, Payen E, Maouche-Chretien L, Creneguy A, Nguyen TH, Martin N, Piver E, Sevrain R, Lamouroux L, Leboulch P, Deschaseaux F, Bouillé P, Sensébé L, Pagès JC.

Mol Ther Methods Clin Dev. 2015 Oct 21;2:15039. doi: 10.1038/mtm.2015.39. eCollection 2015.


Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins.

Ménoret S, De Cian A, Tesson L, Remy S, Usal C, Boulé JB, Boix C, Fontanière S, Crénéguy A, Nguyen TH, Brusselle L, Thinard R, Gauguier D, Concordet JP, Cherifi Y, Fraichard A, Giovannangeli C, Anegon I.

Sci Rep. 2015 Oct 7;5:14410. doi: 10.1038/srep14410.


Transgenic animals and genetic engineering techniques. Nantes, France, 2-3 July, 2015.

Ménoret S, Tesson L, Remy S, Usal C, Ouisse LH, Brusselle L, Chenouard V, Nguyen TH, David L, Anegon I.

Transgenic Res. 2015 Dec;24(6):1079-85. doi: 10.1007/s11248-015-9904-6. Epub 2015 Sep 10. No abstract available.


Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat.

Tolosa L, López S, Pareja E, Donato MT, Myara A, Nguyen TH, Castell JV, Gómez-Lechón MJ.

Liver Transpl. 2015 Jun;21(6):801-11. doi: 10.1002/lt.24121.


Hepatic lentiviral gene transfer prevents the long-term onset of hepatic tumours of glycogen storage disease type 1a in mice.

Clar J, Mutel E, Gri B, Creneguy A, Stefanutti A, Gaillard S, Ferry N, Beuf O, Mithieux G, Nguyen TH, Rajas F.

Hum Mol Genet. 2015 Apr 15;24(8):2287-96. doi: 10.1093/hmg/ddu746. Epub 2015 Jan 5.


Correction of hyperbilirubinemia in gunn rats by surgical delivery of low doses of helper-dependent adenoviral vectors.

Schmitt F, Pastore N, Abarrategui-Pontes C, Flageul M, Myara A, Laplanche S, Labrune P, Podevin G, Nguyen TH, Brunetti-Pierri N.

Hum Gene Ther Methods. 2014 Jun;25(3):181-6. doi: 10.1089/hgtb.2013.236. Epub 2014 Apr 14.


Evolution of exchangeable copper and relative exchangeable copper through the course of Wilson's disease in the Long Evans Cinnamon rat.

Schmitt F, Podevin G, Poupon J, Roux J, Legras P, Trocello JM, Woimant F, Laprévote O, Nguyen TH, El Balkhi S.

PLoS One. 2013 Dec 17;8(12):e82323. doi: 10.1371/journal.pone.0082323. eCollection 2013.


Editorial (hot topic: stem-cell reprogramming for medicine).

Nguyen TH.

Curr Gene Ther. 2013 Apr;13(2):71-2. No abstract available.


Specific micro RNA-regulated TetR-KRAB transcriptional control of transgene expression in viral vector-transduced cells.

Pichard V, Aubert D, Boni S, Battaglia S, Ivacik D, Nguyen TH, Arbuthnot P, Ferry N.

PLoS One. 2012;7(12):e51952. doi: 10.1371/journal.pone.0051952. Epub 2012 Dec 14.


Priming of hepatocytes enhances in vivo liver transduction with lentiviral vectors in adult mice.

Pichard V, Boni S, Baron W, Nguyen TH, Ferry N.

Hum Gene Ther Methods. 2012 Feb;23(1):8-17. doi: 10.1089/hgtb.2011.010.


Retroviral vector-mediated gene therapy for metabolic diseases: an update.

Ferry N, Pichard V, Sébastien Bony DA, Nguyen TH.

Curr Pharm Des. 2011;17(24):2516-27. Review.


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