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Acta Biomed. 2020 Mar 19;91(1):161-164. doi: 10.23750/abm.v91i1.9402.

Natural small molecules as inhibitors of coronavirus lipid-dependent attachment to host cells: a possible strategy for reducing SARS-COV-2 infectivity?

Author information

1
MAGI-Euregio, Bolzano, Italy. mirko.baglivo@assomagi.org.
2
Department of Anaesthesia and Intensive Care, Fondazione Poliambulanza, Brescia, Italy. manubaro@aol.it.
3
Department of Anaesthesia and Intensive Care, Fondazione Poliambulanza, Brescia, Italy. Giuseppe.natalini@poliambulanza.it.
4
Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy. tommaso.beccari@unipg.it.
5
Institute of Genomic Medicine, Università Cattolica del Sacro Cuore, Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Rome, Italy. pietro.chiurazzi@unicatt.it.
6
Pathology Division of Anatomic Pathology Dept. of Surgical and Diagnostic Sciences (DISC) University of Genova, Italy; UOSD Fetal Pathology and Ginecology IRCCS . Istituto Giannina Gaslini, Genova, Italy. ezio.fulcheri@unige.it.
7
Institute G. Gaslini, Children's Hospital, Genova, Italy. paolo.petralia@anspi.net.
8
Department of Vascular Rehabilitation, San Giovanni Battista Hospital, Rome, Italy. s.michelini@acismom.it.
9
Pharmacy Fiorentini, Brescia, Italy. mirko.baglivo@assomagi.org.
10
Human Nutrition Research Center, Sacro Cuore Catholic University, Rome, Italy. GiacintoAbele.Miggiano@unicatt.it.
11
Department of Chemistry, Biology and Biotechnology, University of Perugia, Perugia, Italy. assunta.morresi@unipg.it.
12
Department of Surgery, Fondazione Poliambulanza, Brescia, Italy. gerolamotonini@libero.it.
13
MAGI-Euregio, Bolzano, Italy; EBTNA-Lab, Rovereto (TN), Italy. matteo.bertelli@assomagi.org.

Abstract

BACKGROUND:

Viral infectivity depends on interactions between components of the host cell plasma membrane and the virus envelope. Here we review strategies that could help stem the advance of the SARS-COV-2 epidemic.

METHODS AND RESULTS:

We focus on the role of lipid structures, such as lipid rafts and cholesterol, involved in the process, mediated by endocytosis, by which viruses attach to and infect cells. Previous studies have shown that many naturally derived substances, such as cyclodextrin and sterols, could reduce the infectivity of many types of viruses, including the coronavirus family, through interference with lipid-dependent attachment to human host cells.

CONCLUSIONS:

Certain molecules prove able to reduce the infectivity of some coronaviruses, possibly by inhibiting viral lipid-dependent attachment to host cells. More research into these molecules and methods would be worthwhile as it could provide insights the mechanism of transmission of SARS-COV-2 and, into how they could become a basis for new antiviral strategies.

PMID:
32191676
DOI:
10.23750/abm.v91i1.9402
[Indexed for MEDLINE]

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