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Items: 1 to 20 of 147

1.

Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA.

Lopez Quezada L, Silve S, Kelinske M, Liba A, Diaz Gonzalez C, Kotev M, Goullieux L, Sans S, Roubert C, Lagrange S, Bacqué E, Couturier C, Pellet A, Blanc I, Ferron M, Debu F, Li K, Aubé J, Roberts J, Little D, Ling Y, Zhang J, Gold B, Nathan C.

MBio. 2019 Jul 9;10(4). pii: e01405-19. doi: 10.1128/mBio.01405-19.

2.

JEM Editorial Board: Expanding on the basis of cancer.

Nathan CF, Nussenzweig MC, Pulvirenti T.

J Exp Med. 2019 Aug 5;216(8):1725. doi: 10.1084/jem.20191171. Epub 2019 Jul 1. No abstract available.

PMID:
31262843
3.

Dual-Pharmacophore Pyrithione-Containing Cephalosporins Kill Both Replicating and Nonreplicating Mycobacterium tuberculosis.

Lopez Quezada L, Li K, McDonald SL, Nguyen Q, Perkowski AJ, Pharr CW, Gold B, Roberts J, McAulay K, Saito K, Somersan Karakaya S, Javidnia PE, Porras de Francisco E, Amieva MM, Dı Az SP, Mendoza Losana A, Zimmerman M, Liang HH, Zhang J, Dartois V, Sans S, Lagrange S, Goullieux L, Roubert C, Nathan C, Aubé J.

ACS Infect Dis. 2019 Aug 9;5(8):1433-1445. doi: 10.1021/acsinfecdis.9b00112. Epub 2019 Jun 11.

PMID:
31184461
4.

Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in Mycobacterium tuberculosis.

Wu J, Mu R, Sun M, Zhao N, Pan M, Li H, Dong Y, Sun Z, Bai J, Hu M, Nathan CF, Javid B, Liu G.

ACS Infect Dis. 2019 Jul 12;5(7):1087-1104. doi: 10.1021/acsinfecdis.8b00325. Epub 2019 May 3.

PMID:
31016962
5.

Effect of C-2 substitution on the stability of non-traditional cephalosporins in mouse plasma.

Zimmerman M, McDonald SL, Ho-Liang HP, Porubsky P, Nguyen Q, Pharr CW, Perkowski AJ, Smith R, Schoenen FJ, Gold BS, Zhang D, Nathan CF, Dartois V, Aubé J.

J Antibiot (Tokyo). 2019 Jun;72(6):469-475. doi: 10.1038/s41429-019-0167-y. Epub 2019 Mar 22.

PMID:
30903100
6.

Opposing reactions in coenzyme A metabolism sensitize Mycobacterium tuberculosis to enzyme inhibition.

Ballinger E, Mosior J, Hartman T, Burns-Huang K, Gold B, Morris R, Goullieux L, Blanc I, Vaubourgeix J, Lagrange S, Fraisse L, Sans S, Couturier C, Bacqué E, Rhee K, Scarry SM, Aubé J, Yang G, Ouerfelli O, Schnappinger D, Ioerger TR, Engelhart CA, McConnell JA, McAulay K, Fay A, Roubert C, Sacchettini J, Nathan C.

Science. 2019 Feb 1;363(6426). pii: eaau8959. doi: 10.1126/science.aau8959. Erratum in: Science. 2019 Jun 21;364(6446):.

7.

Identification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis.

Early J, Ollinger J, Darby C, Alling T, Mullen S, Casey A, Gold B, Ochoada J, Wiernicki T, Masquelin T, Nathan C, Hipskind PA, Parish T.

ACS Infect Dis. 2019 Feb 8;5(2):272-280. doi: 10.1021/acsinfecdis.8b00256. Epub 2018 Dec 17.

8.

Differentially Detectable Mycobacterium tuberculosis Cells in Sputum from Treatment-Naive Subjects in Haiti and Their Proportionate Increase after Initiation of Treatment.

McAulay K, Saito K, Warrier T, Walsh KF, Mathurin LD, Royal-Mardi G, Lee MH, Ocheretina O, Pape JW, Fitzgerald DW, Nathan CF.

MBio. 2018 Nov 20;9(6). pii: e02192-18. doi: 10.1128/mBio.02192-18.

9.

Correction: Improved Control of Tuberculosis and Activation of Macrophages in Mice Lacking Protein Kinase R.

Wu K, Koo J, Jiang X, Chen R, Cohen SN, Nathan C.

PLoS One. 2018 Oct 5;13(10):e0205424. doi: 10.1371/journal.pone.0205424. eCollection 2018.

10.

ATP hydrolysis-coupled peptide translocation mechanism of Mycobacterium tuberculosis ClpB.

Yu H, Lupoli TJ, Kovach A, Meng X, Zhao G, Nathan CF, Li H.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9560-E9569. doi: 10.1073/pnas.1810648115. Epub 2018 Sep 26.

11.

Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance.

Kirkman LA, Zhan W, Visone J, Dziedziech A, Singh PK, Fan H, Tong X, Bruzual I, Hara R, Kawasaki M, Imaeda T, Okamoto R, Sato K, Michino M, Alvaro EF, Guiang LF, Sanz L, Mota DJ, Govindasamy K, Wang R, Ling Y, Tumwebaze PK, Sukenick G, Shi L, Vendome J, Bhanot P, Rosenthal PJ, Aso K, Foley MA, Cooper RA, Kafsack B, Doggett JS, Nathan CF, Lin G.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):E6863-E6870. doi: 10.1073/pnas.1806109115. Epub 2018 Jul 2.

12.

Identification of a Mycothiol-Dependent Nitroreductase from Mycobacterium tuberculosis.

Negri A, Javidnia P, Mu R, Zhang X, Vendome J, Gold B, Roberts J, Barman D, Ioerger T, Sacchettini JC, Jiang X, Burns-Huang K, Warrier T, Ling Y, Warren JD, Oren DA, Beuming T, Wang H, Wu J, Li H, Rhee KY, Nathan CF, Liu G, Somersan-Karakaya S.

ACS Infect Dis. 2018 May 11;4(5):771-787. doi: 10.1021/acsinfecdis.7b00111. Epub 2018 Feb 21.

13.

Evidence for dispensability of protein kinase R in host control of tuberculosis.

Mundhra S, Bryk R, Hawryluk N, Zhang T, Jiang X, Nathan CF.

Eur J Immunol. 2018 Apr;48(4):612-620. doi: 10.1002/eji.201747180. Epub 2018 Feb 28.

14.

The new face of JEM.

Nathan C, Nussenzweig M, Pulvirenti T.

J Exp Med. 2017 Dec 4;214(12):3467. doi: 10.1084/jem.20172072.

15.

Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes.

Santos RLA, Bai L, Singh PK, Murakami N, Fan H, Zhan W, Zhu Y, Jiang X, Zhang K, Assker JP, Nathan CF, Li H, Azzi J, Lin G.

Nat Commun. 2017 Nov 22;8(1):1692. doi: 10.1038/s41467-017-01760-5.

16.

Introduction of Laurie H. Glimcher, MD.

Nathan CF.

J Clin Invest. 2017 Oct 2;127(10):3575. doi: 10.1172/JCI97404. Epub 2017 Oct 2. No abstract available.

17.

Distinct Spatiotemporal Dynamics of Peptidoglycan Synthesis between Mycobacterium smegmatis and Mycobacterium tuberculosis.

Botella H, Yang G, Ouerfelli O, Ehrt S, Nathan CF, Vaubourgeix J.

MBio. 2017 Sep 12;8(5). pii: e01183-17. doi: 10.1128/mBio.01183-17.

18.

JEM Advisory Editorial Board: Increasing diversity.

Nathan C, Nussenzweig MC, Pulvirenti T.

J Exp Med. 2017 Jul 26. pii: jem.20171220. doi: 10.1084/jem.20171220. [Epub ahead of print] No abstract available.

19.

Kunkel Lecture: Fundamental immunodeficiency and its correction.

Nathan C.

J Exp Med. 2017 Aug 7;214(8):2175-2191. doi: 10.1084/jem.20170637. Epub 2017 Jul 12. Review.

20.

Rifamycin action on RNA polymerase in antibiotic-tolerant Mycobacterium tuberculosis results in differentially detectable populations.

Saito K, Warrier T, Somersan-Karakaya S, Kaminski L, Mi J, Jiang X, Park S, Shigyo K, Gold B, Roberts J, Weber E, Jacobs WR Jr, Nathan CF.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4832-E4840. doi: 10.1073/pnas.1705385114. Epub 2017 May 30.

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