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Items: 9


Alternative RNA splicing in the endothelium mediated in part by Rbfox2 regulates the arterial response to low flow.

Murphy PA, Butty VL, Boutz PL, Begum S, Kimble AL, Sharp PA, Burge CB, Hynes RO.

Elife. 2018 Jan 2;7. pii: e29494. doi: 10.7554/eLife.29494.


Integrin-targeted cancer immunotherapy elicits protective adaptive immune responses.

Kwan BH, Zhu EF, Tzeng A, Sugito HR, Eltahir AA, Ma B, Delaney MK, Murphy PA, Kauke MJ, Angelini A, Momin N, Mehta NK, Maragh AM, Hynes RO, Dranoff G, Cochran JR, Wittrup KD.

J Exp Med. 2017 Jun 5;214(6):1679-1690. doi: 10.1084/jem.20160831. Epub 2017 May 4.


Mouse Models of Cerebral Arteriovenous Malformation.

Nielsen CM, Huang L, Murphy PA, Lawton MT, Wang RA.

Stroke. 2016 Jan;47(1):293-300. doi: 10.1161/STROKEAHA.115.002869. Epub 2015 Sep 8. No abstract available.


Tumor angiogenesis in the absence of fibronectin or its cognate integrin receptors.

Murphy PA, Begum S, Hynes RO.

PLoS One. 2015 Mar 25;10(3):e0120872. doi: 10.1371/journal.pone.0120872. eCollection 2015.


Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels.

Murphy PA, Kim TN, Huang L, Nielsen CM, Lawton MT, Adams RH, Schaffer CB, Wang RA.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):18007-12. doi: 10.1073/pnas.1415316111. Epub 2014 Dec 2.


Alternative splicing of endothelial fibronectin is induced by disturbed hemodynamics and protects against hemorrhage of the vessel wall.

Murphy PA, Hynes RO.

Arterioscler Thromb Vasc Biol. 2014 Sep;34(9):2042-50. doi: 10.1161/ATVBAHA.114.303879. Epub 2014 Jun 5.


Notch4 normalization reduces blood vessel size in arteriovenous malformations.

Murphy PA, Kim TN, Lu G, Bollen AW, Schaffer CB, Wang RA.

Sci Transl Med. 2012 Jan 18;4(117):117ra8. doi: 10.1126/scitranslmed.3002670.


Endothelial Notch signaling is upregulated in human brain arteriovenous malformations and a mouse model of the disease.

Murphy PA, Lu G, Shiah S, Bollen AW, Wang RA.

Lab Invest. 2009 Sep;89(9):971-82. doi: 10.1038/labinvest.2009.62. Epub 2009 Jun 22. Erratum in: Lab Invest. 2009 Sep;89(9):1071.


Endothelial Notch4 signaling induces hallmarks of brain arteriovenous malformations in mice.

Murphy PA, Lam MT, Wu X, Kim TN, Vartanian SM, Bollen AW, Carlson TR, Wang RA.

Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10901-6. doi: 10.1073/pnas.0802743105. Epub 2008 Jul 30.

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