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Year Number of Results
2004 3
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33 results

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Methylselenocysteine preventing castration-resistant progression of prostate cancer.
Liu Y, Liu X, Guo Y, Liang Z, Tian Y, Lu L, Zhao X, Sun Y, Zhao X, Zhang H, Dong Y. Liu Y, et al. Prostate. 2015 Jun 15;75(9):1001-8. doi: 10.1002/pros.22987. Epub 2015 Mar 8. Prostate. 2015. PMID: 25754033 Free PMC article.
Here we investigated the ability of methylselenocysteine to inhibit castration-resistant progression of prostate cancer. ...CONCLUSIONS: The present study represents the first to show the preclinical efficacy of methylselenocysteine in delaying castration-res …
Here we investigated the ability of methylselenocysteine to inhibit castration-resistant progression of prostate cancer. ...CO …
Effect of Dietary Methylseleninic Acid and Se-Methylselenocysteine on Carcinogen-Induced, Androgen-Promoted Prostate Carcinogenesis in Rats.
Bosland MC, Schlicht MJ, Deng Y, Lü J. Bosland MC, et al. Nutr Cancer. 2022;74(10):3761-3768. doi: 10.1080/01635581.2022.2093387. Epub 2022 Jun 28. Nutr Cancer. 2022. PMID: 35762420 Free PMC article. Clinical Trial.
Selenomethionine (SeMet) did not prevent prostate cancer in the SELECT trial and in two hormone-driven rat models. However, we have shown that daily oral bolus administration of next-generation selenium forms, methylseleninic acid (MSeA) and Se-methylselenocysteine …
Selenomethionine (SeMet) did not prevent prostate cancer in the SELECT trial and in two hormone-driven rat models. However, we have s …
Combination effects of dietary soy and methylselenocysteine in a mouse model of prostate cancer.
Christensen MJ, Quiner TE, Nakken HL, Lephart ED, Eggett DL, Urie PM. Christensen MJ, et al. Prostate. 2013 Jun;73(9):986-95. doi: 10.1002/pros.22646. Epub 2013 Feb 6. Prostate. 2013. PMID: 23389815 Free PMC article.
BACKGROUND: High dietary intake of soy or selenium (Se) is associated with decreased risk of prostate cancer. Soy constituents and various chemical forms of Se have each been shown to downregulate expression of the androgen receptor (AR) and AR-regulated genes in the pr …
BACKGROUND: High dietary intake of soy or selenium (Se) is associated with decreased risk of prostate cancer. Soy constituents and va …
Se-methylselenocysteine suppresses the growth of prostate cancer cell DU145 through connexin 43-induced apoptosis.
Lu Z, Qi L, Li GX, Bo XJ, Liu GD, Wang JM. Lu Z, et al. J Cancer Res Ther. 2015 Oct-Dec;11(4):840-5. doi: 10.4103/0973-1482.139265. J Cancer Res Ther. 2015. PMID: 26881528 Free article.
CONTEXT: Se-methylselenocysteine (MSC), as a chemopreventive agent, shows antitumor effects in some cancer models, but its mechanism is still unclear. AIMS: This study is to explore whether MSC induces apoptosis in prostate cancer (PCa) cells DU145 through connexin …
CONTEXT: Se-methylselenocysteine (MSC), as a chemopreventive agent, shows antitumor effects in some cancer models, but its mechanism …
The mechanism of methylselenocysteine and docetaxel synergistic activity in prostate cancer cells.
Azrak RG, Frank CL, Ling X, Slocum HK, Li F, Foster BA, Rustum YM. Azrak RG, et al. Mol Cancer Ther. 2006 Oct;5(10):2540-8. doi: 10.1158/1535-7163.MCT-05-0546. Mol Cancer Ther. 2006. PMID: 17041098 Free PMC article.
The study was designed to evaluate the combination treatment of methylselenocysteine (MSeC) and docetaxel and to delineate the underlying mechanism associated with observed in vitro synergy between MSeC and docetaxel in prostate cancer cells. ...In conclusion, pretr …
The study was designed to evaluate the combination treatment of methylselenocysteine (MSeC) and docetaxel and to delineate the underl …
Se-methylselenocysteine alters collagen gene and protein expression in human prostate cells.
Hurst R, Elliott RM, Goldson AJ, Fairweather-Tait SJ. Hurst R, et al. Cancer Lett. 2008 Sep 28;269(1):117-26. doi: 10.1016/j.canlet.2008.04.025. Epub 2008 Jun 2. Cancer Lett. 2008. PMID: 18514395
The anti-cancer activity of selenium is dose-dependent and species-specific but the mechanism is unclear. Se-methylselenocysteine (MSC), found in selenium-enriched alliums, is one of the most potent forms. We exposed two human prostate cell lines (LNCaP clone FGC an …
The anti-cancer activity of selenium is dose-dependent and species-specific but the mechanism is unclear. Se-methylselenocysteine (MS …
Selenium Biomarkers in Prostate Cancer Cell Lines and Influence of Selenium on Invasive Potential of PC3 Cells.
Hendrickx W, Decock J, Mulholland F, Bao Y, Fairweather-Tait S. Hendrickx W, et al. Front Oncol. 2013 Sep 23;3:239. doi: 10.3389/fonc.2013.00239. eCollection 2013. Front Oncol. 2013. PMID: 24066278 Free PMC article.
., glutathione peroxidase 1 (GPx1) and thioredoxin reductase 1 (TrxR1), to determine appropriate selenium levels for in vitro work. Furthermore, we investigated the effects of Se-methylselenocysteine (SeMSC) on prostate cancer cell migration and invasion. After excl …
., glutathione peroxidase 1 (GPx1) and thioredoxin reductase 1 (TrxR1), to determine appropriate selenium levels for in vitro work. Furtherm …
Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefit.
Wang L, Bonorden MJ, Li GX, Lee HJ, Hu H, Zhang Y, Liao JD, Cleary MP, Lü J. Wang L, et al. Cancer Prev Res (Phila). 2009 May;2(5):484-95. doi: 10.1158/1940-6207.CAPR-08-0173. Epub 2009 Apr 28. Cancer Prev Res (Phila). 2009. PMID: 19401524 Free PMC article.
Here we used the transgenic adenocarcinoma mouse prostate (TRAMP) model to establish the efficacy of methylseleninic acid (MSeA) and methylselenocysteine (MSeC) against prostate carcinogenesis and to characterize potential mechanisms. ...Therefore, these sele …
Here we used the transgenic adenocarcinoma mouse prostate (TRAMP) model to establish the efficacy of methylseleninic acid (MSeA) and …
Mouse prostate proteomes are differentially altered by supranutritional intake of four selenium compounds.
Zhang J, Wang L, Li G, Anderson LB, Xu Y, Witthuhn B, Lü J. Zhang J, et al. Nutr Cancer. 2011;63(5):778-89. doi: 10.1080/01635581.2011.563029. Epub 2011 Jun 1. Nutr Cancer. 2011. PMID: 21614726
We have shown that, in contrast to selenomethionine (SeMet) or selenite, methylseleninic acid (MSeA) and Se-methylselenocysteine (MSeC) exert prostate cancer (PCa) inhibitory effect in preclinical models. ...We propose that the balance of oncogenic vs. suppressor pr …
We have shown that, in contrast to selenomethionine (SeMet) or selenite, methylseleninic acid (MSeA) and Se-methylselenocysteine (MSe …
Methylseleninic acid elevates REDD1 and inhibits prostate cancer cell growth despite AKT activation and mTOR dysregulation in hypoxia.
Sinha I, Allen JE, Pinto JT, Sinha R. Sinha I, et al. Cancer Med. 2014 Apr;3(2):252-64. doi: 10.1002/cam4.198. Epub 2014 Feb 7. Cancer Med. 2014. PMID: 24515947 Free PMC article.
We have now extended these studies to evaluate the impact of MSeA on REDD1 (an mTOR inhibitor) in inducing cell death of invasive prostate cancer cells in hypoxia. In both PTEN+ and PTEN- prostate cancer cells we show that MSeA elevates REDD1 and phosphorylation of …
We have now extended these studies to evaluate the impact of MSeA on REDD1 (an mTOR inhibitor) in inducing cell death of invasive prostat …
33 results