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Int J Clin Exp Pathol. 2015 Dec 1;8(12):15919-25. eCollection 2015.

PAI-1 and TNF-α profiles of adipose tissue in obese cardiovascular disease patients.

Author information

1
Department of Immunology, Institute for Experimental Medicine, Istanbul University Istanbul, Turkey.
2
Department of Pediatrics, Pediatric Endocrinology Unit, Istanbul Faculty of Medicine, Istanbul University Istanbul, Turkey.

Abstract

Obesity as a leading preventable cause of death worldwide is closely linked to cardiovascular disease (CVD). Plasma plasminogen activator inhibitor (PAI)-1, a potent inhibitor of plasminogen activation and fibrinolysis, is increased in many clinical situations associated with high incidence of CVD. In the obesity-linked elevation of PAI-1, evidence points to TNF-α as an important regulator of PAI-1 expression in adipose tissue.

BACKGROUND:

This study aims to evaluate mediastinal PAI-1 and TNF-α mRNA levels in adipose tissues (AT) and compare serum levels in obesity with and without coronary artery disease (CAD).

PATIENTS AND METHODS:

Obese patients with (n=37) and without CAD (n=20) were included in the study.

RESULTS:

The serum levels of PAI-1 and TNF-α were significantly higher in obese patients with CAD compared to obese patients without CAD. PAI-1 mRNA expression was significantly increased in mediastinal adipose tissue (MAT) of obese patients with CAD compared to those without CAD, TNF-α mRNA expressions were found to be higher in EAT (epicardial AT), MAT and SAT (subcutaneous AT) of obese patients with CAD.

CONCLUSIONS:

The study demonstrated a close direct relationship between TNF-α and PAI-1. PAI-1 mRNA expression strongly correlated positively with serum TNF-α in MAT, and TNF-α expressions with PAI-1 serum levels.

KEYWORDS:

PAI-1; TNF-α; adipose tissue; cardiovascular disease

PMID:
26884864
PMCID:
PMC4730077
[Indexed for MEDLINE]
Free PMC Article

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