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Ann Diagn Pathol. 2009 Jun;13(3):185-8. doi: 10.1016/j.anndiagpath.2008.02.006. Epub 2008 Jun 12.

Thymolipoma: clues to pathogenesis revealed by cytogenetics.

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Department of Pathology and Laboratory Medicine, Robert Wood Johnson Medical School, NJ 08903, USA.


The pathogenesis of thymolipoma is controversial and unclear despite numerous reports. A case report of thymolipoma with cytogenetic analysis is herein presented. The lesion demonstrated a translocation involving the HMGA2 gene on chromosome 12q15, which is seen in two thirds of solitary lipomas. This finding supports the theory that this case of thymolipoma is a neoplasm of thymic fat.

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