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Items: 19

1.

Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage.

Li ZR, Li J, Cai W, Lai JYH, McKinnie SMK, Zhang WP, Moore BS, Zhang W, Qian PY.

Nat Chem. 2019 Oct;11(10):880-889. doi: 10.1038/s41557-019-0317-7. Epub 2019 Sep 16.

PMID:
31527851
2.

Scalable Biosynthesis of the Seaweed Neurochemical, Kainic Acid.

Chekan JR, McKinnie SMK, Moore ML, Poplawski SG, Michael TP, Moore BS.

Angew Chem Int Ed Engl. 2019 Jun 17;58(25):8454-8457. doi: 10.1002/anie.201902910. Epub 2019 May 10.

PMID:
30995339
3.

Biosynthesis of l-4-Chlorokynurenine, an Antidepressant Prodrug and a Non-Proteinogenic Amino Acid Found in Lipopeptide Antibiotics.

Luhavaya H, Sigrist R, Chekan JR, McKinnie SMK, Moore BS.

Angew Chem Int Ed Engl. 2019 Jun 17;58(25):8394-8399. doi: 10.1002/anie.201901571. Epub 2019 May 13.

PMID:
30963655
4.

Synthesis, bioactivity, and enzymatic modification of antibacterial thiotetromycin derivatives.

Rothe ML, Li J, Garibay E, Moore BS, McKinnie SMK.

Org Biomol Chem. 2019 Mar 27;17(13):3416-3423. doi: 10.1039/c8ob03109f.

PMID:
30869693
5.

Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents.

Fischer C, Lamer T, Wang W, McKinnie SMK, Iturrioz X, Llorens-Cortes C, Oudit GY, Vederas JC.

Eur J Med Chem. 2019 Mar 15;166:119-124. doi: 10.1016/j.ejmech.2019.01.040. Epub 2019 Jan 18.

PMID:
30690406
6.

Total Enzyme Syntheses of Napyradiomycins A1 and B1.

McKinnie SMK, Miles ZD, Jordan PA, Awakawa T, Pepper HP, Murray LAM, George JH, Moore BS.

J Am Chem Soc. 2018 Dec 26;140(51):17840-17845. doi: 10.1021/jacs.8b10134. Epub 2018 Dec 14.

7.

Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom.

Brunson JK, McKinnie SMK, Chekan JR, McCrow JP, Miles ZD, Bertrand EM, Bielinski VA, Luhavaya H, Oborník M, Smith GJ, Hutchins DA, Allen AE, Moore BS.

Science. 2018 Sep 28;361(6409):1356-1358. doi: 10.1126/science.aau0382.

8.

Total Synthesis Establishes the Biosynthetic Pathway to the Naphterpin and Marinone Natural Products.

Murray LAM, McKinnie SMK, Pepper HP, Erni R, Miles ZD, Cruickshank MC, López-Pérez B, Moore BS, George JH.

Angew Chem Int Ed Engl. 2018 Aug 20;57(34):11009-11014. doi: 10.1002/anie.201804351. Epub 2018 Jul 23.

9.

Correction to Organohalogens Naturally Biosynthesized in Marine Environments and Produced As Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics.

Zheng J, McKinnie SMK, El Gamal A, Feng W, Dong Y, Agarwal V, Fenical W, Kumar A, Cao Z, Moore BS, Pessah IN.

Environ Sci Technol. 2018 Jul 3;52(13):7594. doi: 10.1021/acs.est.8b03174. Epub 2018 Jun 19. No abstract available.

PMID:
29916692
10.

Characterization and Biochemical Assays of Streptomyces Vanadium-Dependent Chloroperoxidases.

McKinnie SMK, Miles ZD, Moore BS.

Methods Enzymol. 2018;604:405-424. doi: 10.1016/bs.mie.2018.02.016. Epub 2018 Apr 2.

11.

Organohalogens Naturally Biosynthesized in Marine Environments and Produced as Disinfection Byproducts Alter Sarco/Endoplasmic Reticulum Ca2+ Dynamics.

Zheng J, McKinnie SMK, El Gamal A, Feng W, Dong Y, Agarwal V, Fenical W, Kumar A, Cao Z, Moore BS, Pessah IN.

Environ Sci Technol. 2018 May 1;52(9):5469-5478. doi: 10.1021/acs.est.8b00512. Epub 2018 Apr 20. Erratum in: Environ Sci Technol. 2018 Jul 3;52(13):7594.

12.

Synthetic Modification within the "RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation.

McKinnie SMK, Wang W, Fischer C, McDonald T, Kalin KR, Iturrioz X, Llorens-Cortes C, Oudit GY, Vederas JC.

J Med Chem. 2017 Jul 27;60(14):6408-6427. doi: 10.1021/acs.jmedchem.7b00723. Epub 2017 Jul 7.

PMID:
28685579
13.

Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.

Zhong JC, Zhang ZZ, Wang W, McKinnie SMK, Vederas JC, Oudit GY.

Biochim Biophys Acta Mol Basis Dis. 2017 Aug;1863(8):1942-1950. doi: 10.1016/j.bbadis.2016.11.007. Epub 2016 Nov 4. Review.

14.

The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides.

McKinnie SM, Fischer C, Tran KM, Wang W, Mosquera F, Oudit GY, Vederas JC.

Chembiochem. 2016 Aug 17;17(16):1495-8. doi: 10.1002/cbic.201600244. Epub 2016 Jul 5.

PMID:
27377680
15.

Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System.

Wang W, McKinnie SM, Farhan M, Paul M, McDonald T, McLean B, Llorens-Cortes C, Hazra S, Murray AG, Vederas JC, Oudit GY.

Hypertension. 2016 Aug;68(2):365-77. doi: 10.1161/HYPERTENSIONAHA.115.06892. Epub 2016 May 23.

PMID:
27217402
16.

Differential response of orthologous L,L-diaminopimelate aminotransferases (DapL) to enzyme inhibitory antibiotic lead compounds.

McKinnie SM, Rodriguez-Lopez EM, Vederas JC, Crowther JM, Suzuki H, Dobson RC, Leustek T, Triassi AJ, Wheatley MS, Hudson AO.

Bioorg Med Chem. 2014 Jan 1;22(1):523-30. doi: 10.1016/j.bmc.2013.10.055. Epub 2013 Nov 9.

17.

Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues.

Wang W, McKinnie SM, Patel VB, Haddad G, Wang Z, Zhabyeyev P, Das SK, Basu R, McLean B, Kandalam V, Penninger JM, Kassiri Z, Vederas JC, Murray AG, Oudit GY.

J Am Heart Assoc. 2013 Jul 1;2(4):e000249. doi: 10.1161/JAHA.113.000249.

18.

The synthesis of active and stable diaminopimelate analogues of the lantibiotic peptide lactocin S.

Ross AC, McKinnie SM, Vederas JC.

J Am Chem Soc. 2012 Feb 1;134(4):2008-11. doi: 10.1021/ja211088m. Epub 2012 Jan 24.

PMID:
22280450
19.

Solid-supported synthesis and biological evaluation of the lantibiotic peptide bis(desmethyl) lacticin 3147 A2.

Pattabiraman VR, McKinnie SM, Vederas JC.

Angew Chem Int Ed Engl. 2008;47(49):9472-5. doi: 10.1002/anie.200802919. No abstract available.

PMID:
18937239

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