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Nutrients. 2016 Nov 25;8(12). pii: E757.

Maternal Fructose Intake Affects Transcriptome Changes and Programmed Hypertension in Offspring in Later Life.

Author information

1
Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. tainyl@hotmail.com.
2
Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. tainyl@hotmail.com.
3
Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan. jchan@cgmh.org.tw.
4
Department of Pharmacy, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan. chien_ning_hsu@hotmail.com.
5
School of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan. chien_ning_hsu@hotmail.com.

Abstract

Hypertension originates from early-life insults by so-called "developmental origins of health and disease" (DOHaD). Studies performed in the previous few decades indicate that fructose consumption is associated with an increase in hypertension rate. It is emerging field that tends to unfold the nutrient-gene interactions of maternal high-fructose (HF) intake on the offspring which links renal programming to programmed hypertension. Reprogramming interventions counteract disturbed nutrient-gene interactions induced by maternal HF intake and exert protective effects against developmentally programmed hypertension. Here, we review the key themes on the effect of maternal HF consumption on renal transcriptome changes and programmed hypertension. We have particularly focused on the following areas: metabolic effects of fructose on hypertension and kidney disease; effects of maternal HF consumption on hypertension development in adult offspring; effects of maternal HF consumption on renal transcriptome changes; and application of reprogramming interventions to prevent maternal HF consumption-induced programmed hypertension in animal models. Provision of personalized nutrition is still a faraway goal. Therefore, there is an urgent need to understand early-life nutrient-gene interactions and to develop effective reprogramming strategies for treating hypertension and other HF consumption-related diseases.

KEYWORDS:

developmental origins of health and disease (DOHaD); developmental programming; fructose; hypertension; kidney; next-generation sequencing; reprogramming; transcriptome

PMID:
27897982
PMCID:
PMC5188412
DOI:
10.3390/nu8120757
[Indexed for MEDLINE]
Free PMC Article

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