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Items: 1 to 20 of 41

1.

Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening.

Velnati S, Ruffo E, Massarotti A, Talmon M, Varma KSS, Gesu A, Fresu LG, Snow AL, Bertoni A, Capello D, Tron GC, Graziani A, Baldanzi G.

Eur J Med Chem. 2019 Feb 15;164:378-390. doi: 10.1016/j.ejmech.2018.12.061. Epub 2018 Dec 26.

2.

ZINClick v.18: Expanding Chemical Space of 1,2,3-Triazoles.

Levré D, Arcisto C, Mercalli V, Massarotti A.

J Chem Inf Model. 2018 Nov 27. doi: 10.1021/acs.jcim.8b00615. [Epub ahead of print]

PMID:
30419167
3.

Rational Discovery of (+) (S) Abscisic Acid as a Potential Antifungal Agent: a Repurposing Approach.

Khedr MA, Massarotti A, Mohamed ME.

Sci Rep. 2018 Jun 4;8(1):8565. doi: 10.1038/s41598-018-26998-x.

4.

Crystal structure of a thermophilic O6-alkylguanine-DNA alkyltransferase-derived self-labeling protein-tag in covalent complex with a fluorescent probe.

Rossi F, Morrone C, Massarotti A, Ferraris DM, Valenti A, Perugino G, Miggiano R.

Biochem Biophys Res Commun. 2018 Jun 7;500(3):698-703. doi: 10.1016/j.bbrc.2018.04.139. Epub 2018 Apr 30.

PMID:
29684348
5.

A multicomponent approach in the discovery of indoleamine 2,3-dioxygenase 1 inhibitors: Synthesis, biological investigation and docking studies.

Griglio A, Torre E, Serafini M, Bianchi A, Schmid R, Coda Zabetta G, Massarotti A, Sorba G, Pirali T, Fallarini S.

Bioorg Med Chem Lett. 2018 Feb 15;28(4):651-657. doi: 10.1016/j.bmcl.2018.01.032. Epub 2018 Feb 2.

PMID:
29398544
6.

The hitchhiker's guide to the chemical-biological galaxy.

Opassi G, Gesù A, Massarotti A.

Drug Discov Today. 2018 Mar;23(3):565-574. doi: 10.1016/j.drudis.2018.01.007. Epub 2018 Jan 9. Review.

PMID:
29330125
7.

Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.

Pirali T, Ciraolo E, Aprile S, Massarotti A, Berndt A, Griglio A, Serafini M, Mercalli V, Landoni C, Campa CC, Margaria JP, Silva RL, Grosa G, Sorba G, Williams R, Hirsch E, Tron GC.

ChemMedChem. 2017 Sep 21;12(18):1542-1554. doi: 10.1002/cmdc.201700340. Epub 2017 Aug 31.

8.

Structural investigations on orotate phosphoribosyltransferase from Mycobacterium tuberculosis, a key enzyme of the de novo pyrimidine biosynthesis.

Donini S, Ferraris DM, Miggiano R, Massarotti A, Rizzi M.

Sci Rep. 2017 Apr 26;7(1):1180. doi: 10.1038/s41598-017-01057-z.

9.

Identification of Novel Triazole-Based Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors Endowed with Antiproliferative and Antiinflammatory Activity.

Travelli C, Aprile S, Rahimian R, Grolla AA, Rogati F, Bertolotti M, Malagnino F, di Paola R, Impellizzeri D, Fusco R, Mercalli V, Massarotti A, Stortini G, Terrazzino S, Del Grosso E, Fakhfouri G, Troiani MP, Alisi MA, Grosa G, Sorba G, Canonico PL, Orsomando G, Cuzzocrea S, Genazzani AA, Galli U, Tron GC.

J Med Chem. 2017 Mar 9;60(5):1768-1792. doi: 10.1021/acs.jmedchem.6b01392. Epub 2017 Feb 22.

PMID:
28165742
10.

To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis.

Giustiniano M, Basso A, Mercalli V, Massarotti A, Novellino E, Tron GC, Zhu J.

Chem Soc Rev. 2017 Mar 6;46(5):1295-1357. doi: 10.1039/c6cs00444j. Review.

PMID:
27983738
11.

The metal face of protein tyrosine phosphatase 1B.

Bellomo E, Birla Singh K, Massarotti A, Hogstrand C, Maret W.

Coord Chem Rev. 2016 Nov 15;327-328:70-83. Review.

12.

Interdomain interactions rearrangements control the reaction steps of a thermostable DNA alkyltransferase.

Morrone C, Miggiano R, Serpe M, Massarotti A, Valenti A, Del Monaco G, Rossi M, Rossi F, Rizzi M, Perugino G, Ciaramella M.

Biochim Biophys Acta Gen Subj. 2017 Feb;1861(2):86-96. doi: 10.1016/j.bbagen.2016.10.020. Epub 2016 Oct 22.

PMID:
27777086
13.

Structural biology in antiviral drug discovery.

Bassetto M, Massarotti A, Coluccia A, Brancale A.

Curr Opin Pharmacol. 2016 Oct;30:116-130. doi: 10.1016/j.coph.2016.08.014. Epub 2016 Sep 6. Review.

PMID:
27611878
14.

An in-silico approach aimed to clarify the role of Y181C and K103N HIV-1 reverse transcriptase mutations versus Indole Aryl Sulphones.

Massarotti A, Coluccia A.

J Mol Graph Model. 2016 Jan;63:49-56. doi: 10.1016/j.jmgm.2015.11.013. Epub 2015 Nov 25.

PMID:
26650686
15.

The adverse outcome pathway (AOP) for chemical binding to tubulin in oocytes leading to aneuploid offspring.

Marchetti F, Massarotti A, Yauk CL, Pacchierotti F, Russo A.

Environ Mol Mutagen. 2016 Mar;57(2):87-113. doi: 10.1002/em.21986. Epub 2015 Nov 19. Review.

PMID:
26581746
16.

The Guareschi Pyridine Scaffold as a Valuable Platform for the Identification of Selective PI3K Inhibitors.

Galli U, Ciraolo E, Massarotti A, Margaria JP, Sorba G, Hirsch E, Tron GC.

Molecules. 2015 Sep 18;20(9):17275-87. doi: 10.3390/molecules200917275.

17.

Multicomponent Reaction of Z-Chlorooximes, Isocyanides, and Hydroxylamines as Hypernucleophilic Traps. A One-Pot Route to Aminodioximes and Their Transformation into 5-Amino-1,2,4-oxadiazoles by Mitsunobu-Beckmann Rearrangement.

Mercalli V, Massarotti A, Varese M, Giustiniano M, Meneghetti F, Novellino E, Tron GC.

J Org Chem. 2015 Oct 2;80(19):9652-61. doi: 10.1021/acs.joc.5b01676. Epub 2015 Sep 30.

PMID:
26360930
18.

Crystal structure of human nicotinic acid phosphoribosyltransferase.

Marletta AS, Massarotti A, Orsomando G, Magni G, Rizzi M, Garavaglia S.

FEBS Open Bio. 2015 May 7;5:419-28. doi: 10.1016/j.fob.2015.05.002. eCollection 2015.

19.

Design, synthesis, and biological evaluation of combretabenzodiazepines: a novel class of anti-tubulin agents.

Galli U, Travelli C, Aprile S, Arrigoni E, Torretta S, Grosa G, Massarotti A, Sorba G, Canonico PL, Genazzani AA, Tron GC.

J Med Chem. 2015 Feb 12;58(3):1345-57. doi: 10.1021/jm5016389. Epub 2015 Jan 27.

PMID:
25584687
20.

Solution-phase parallel synthesis of aryloxyimino amides via a novel multicomponent reaction among aromatic (Z)-chlorooximes, isocyanides, and electron-deficient phenols.

Mercalli V, Giustiniano M, Del Grosso E, Varese M, Cassese H, Massarotti A, Novellino E, Tron GC.

ACS Comb Sci. 2014 Nov 10;16(11):602-5. doi: 10.1021/co5000882. Epub 2014 Oct 22.

PMID:
25319356

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