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Items: 1 to 20 of 150

1.

CD25 and Protein Phosphatase 2A Cooperate to Enhance IL-2R Signaling in Human Regulatory T Cells.

Ding Y, Yu A, Tsokos GC, Malek TR.

J Immunol. 2019 Jul 1;203(1):93-104. doi: 10.4049/jimmunol.1801570. Epub 2019 May 13.

PMID:
31085588
2.

Essential and non-overlapping IL-2Rα-dependent processes for thymic development and peripheral homeostasis of regulatory T cells.

Toomer KH, Lui JB, Altman NH, Ban Y, Chen X, Malek TR.

Nat Commun. 2019 Mar 4;10(1):1037. doi: 10.1038/s41467-019-08960-1.

3.

Regulatory T cells in the treatment of disease.

Sharabi A, Tsokos MG, Ding Y, Malek TR, Klatzmann D, Tsokos GC.

Nat Rev Drug Discov. 2018 Nov;17(11):823-844. doi: 10.1038/nrd.2018.148. Epub 2018 Oct 12. Review.

PMID:
30310234
4.

IL-2/CD25: A Long-Acting Fusion Protein That Promotes Immune Tolerance by Selectively Targeting the IL-2 Receptor on Regulatory T Cells.

Ward NC, Yu A, Moro A, Ban Y, Chen X, Hsiung S, Keegan J, Arbanas JM, Loubeau M, Thankappan A, Yamniuk AP, Davis JH, Struthers M, Malek TR.

J Immunol. 2018 Nov 1;201(9):2579-2592. doi: 10.4049/jimmunol.1800907. Epub 2018 Oct 3.

5.

Altered homeostasis and development of regulatory T cell subsets represent an IL-2R-dependent risk for diabetes in NOD mice.

Dwyer CJ, Bayer AL, Fotino C, Yu L, Cabello-Kindelan C, Ward NC, Toomer KH, Chen Z, Malek TR.

Sci Signal. 2017 Dec 19;10(510). pii: eaam9563. doi: 10.1126/scisignal.aam9563.

6.

Cytokine Signaling in the Development and Homeostasis of Regulatory T cells.

Toomer KH, Malek TR.

Cold Spring Harb Perspect Biol. 2018 Mar 1;10(3). pii: a028597. doi: 10.1101/cshperspect.a028597. Review.

PMID:
28620098
7.

The Lower Limit of Regulatory CD4+ Foxp3+ TCRβ Repertoire Diversity Required To Control Autoimmunity.

Yu A, Dee MJ, Adeegbe D, Dwyer CJ, Altman NH, Malek TR.

J Immunol. 2017 Apr 15;198(8):3127-3135. doi: 10.4049/jimmunol.1601966. Epub 2017 Mar 6.

8.

Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner.

Pinto M, Pickrell AM, Wang X, Bacman SR, Yu A, Hida A, Dillon LM, Morton PD, Malek TR, Williams SL, Moraes CT.

Cell Death Differ. 2017 Feb;24(2):288-299. doi: 10.1038/cdd.2016.123. Epub 2016 Dec 2.

9.

Promoting Immune Regulation in Type 1 Diabetes Using Low-Dose Interleukin-2.

Dwyer CJ, Ward NC, Pugliese A, Malek TR.

Curr Diab Rep. 2016 Jun;16(6):46. doi: 10.1007/s11892-016-0739-1. Review.

10.

Developmental Progression and Interrelationship of Central and Effector Regulatory T Cell Subsets.

Toomer KH, Yuan X, Yang J, Dee MJ, Yu A, Malek TR.

J Immunol. 2016 May 1;196(9):3665-76. doi: 10.4049/jimmunol.1500595. Epub 2016 Mar 23.

11.

Low-dose interleukin-2 fosters a dose-dependent regulatory T cell tuned milieu in T1D patients.

Rosenzwajg M, Churlaud G, Mallone R, Six A, Dérian N, Chaara W, Lorenzon R, Long SA, Buckner JH, Afonso G, Pham HP, Hartemann A, Yu A, Pugliese A, Malek TR, Klatzmann D.

J Autoimmun. 2015 Apr;58:48-58. doi: 10.1016/j.jaut.2015.01.001. Epub 2015 Jan 26.

12.

Selective IL-2 responsiveness of regulatory T cells through multiple intrinsic mechanisms supports the use of low-dose IL-2 therapy in type 1 diabetes.

Yu A, Snowhite I, Vendrame F, Rosenzwajg M, Klatzmann D, Pugliese A, Malek TR.

Diabetes. 2015 Jun;64(6):2172-83. doi: 10.2337/db14-1322. Epub 2015 Jan 9.

13.

IL-2Rβ-dependent signaling and CD103 functionally cooperate to maintain tolerance in the gut mucosa.

Yuan X, Dee MJ, Altman NH, Malek TR.

J Immunol. 2015 Feb 1;194(3):1334-46. doi: 10.4049/jimmunol.1400955. Epub 2014 Dec 19.

14.

T regulatory cell adoptive therapy for tolerance induction in autoimmunity and transplantation.

Bayer AL, Malek TR, de la Barrera A, Cabello-Kindelan C.

Am J Transplant. 2014 Oct;14(10):2432-3. doi: 10.1111/ajt.12854. Epub 2014 Jul 9. No abstract available.

15.

The importance of regulatory T-cell heterogeneity in maintaining self-tolerance.

Yuan X, Cheng G, Malek TR.

Immunol Rev. 2014 May;259(1):103-14. doi: 10.1111/imr.12163. Review.

16.

Heat shock protein vaccination and directed IL-2 therapy amplify tumor immunity rapidly following bone marrow transplantation in mice.

Newman RG, Dee MJ, Malek TR, Podack ER, Levy RB.

Blood. 2014 May 8;123(19):3045-55. doi: 10.1182/blood-2013-08-520775. Epub 2014 Mar 31.

17.

In vivo environment necessary to support transplanted donor mouse T regulatory cells.

Cabello-Kindelan C, de la Barrera A, Malek TR, Bayer AL.

Am J Transplant. 2014 May;14(5):1032-45. doi: 10.1111/ajt.12650. Epub 2014 Mar 11.

18.

Aptamer-targeted inhibition of mTOR in T cells enhances antitumor immunity.

Berezhnoy A, Castro I, Levay A, Malek TR, Gilboa E.

J Clin Invest. 2014 Jan;124(1):188-97.

19.

The IL-2/IL-2R system: from basic science to therapeutic applications to enhance immune regulation.

Bayer AL, Pugliese A, Malek TR.

Immunol Res. 2013 Dec;57(1-3):197-209. doi: 10.1007/s12026-013-8452-5. Review.

20.

IL7Rα contributes to experimental autoimmune encephalomyelitis through altered T cell responses and nonhematopoietic cell lineages.

Ashbaugh JJ, Brambilla R, Karmally SA, Cabello C, Malek TR, Bethea JR.

J Immunol. 2013 May 1;190(9):4525-34. doi: 10.4049/jimmunol.1203214. Epub 2013 Mar 25.

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