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Items: 1 to 20 of 148


Dissection of DNA double-strand-break repair using novel single-molecule forceps.

Wang JL, Duboc C, Wu Q, Ochi T, Liang S, Tsutakawa SE, Lees-Miller SP, Nadal M, Tainer JA, Blundell TL, Strick TR.

Nat Struct Mol Biol. 2018 Jun;25(6):482-487. doi: 10.1038/s41594-018-0065-1. Epub 2018 May 21.


Anemia, leukocytosis and thrombocytosis as prognostic factors in patients with cervical cancer treated with radical chemoradiotherapy: A retrospective cohort study.

Koulis TA, Kornaga EN, Banerjee R, Phan T, Ghatage P, Magliocco AM, Lees-Miller SP, Doll CM.

Clin Transl Radiat Oncol. 2017 Jun 12;4:51-56. doi: 10.1016/j.ctro.2017.05.001. eCollection 2017 Jun.


The non-homologous end-joining factor Nej1 inhibits resection mediated by Dna2-Sgs1 nuclease-helicase at DNA double strand breaks.

Sorenson KS, Mahaney BL, Lees-Miller SP, Cobb JA.

J Biol Chem. 2017 Sep 1;292(35):14576-14586. doi: 10.1074/jbc.M117.796011. Epub 2017 Jul 5.


What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses.

Brosey CA, Ahmed Z, Lees-Miller SP, Tainer JA.

Methods Enzymol. 2017;592:417-455. doi: 10.1016/bs.mie.2017.04.005. Epub 2017 May 29. Review.


DNA requirements for interaction of the C-terminal region of Ku80 with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

Radhakrishnan SK, Lees-Miller SP.

DNA Repair (Amst). 2017 Sep;57:17-28. doi: 10.1016/j.dnarep.2017.06.001. Epub 2017 Jun 9.


Structural and functional characterization of the PNKP-XRCC4-LigIV DNA repair complex.

Aceytuno RD, Piett CG, Havali-Shahriari Z, Edwards RA, Rey M, Ye R, Javed F, Fang S, Mani R, Weinfeld M, Hammel M, Tainer JA, Schriemer DC, Lees-Miller SP, Glover JNM.

Nucleic Acids Res. 2017 Jun 2;45(10):6238-6251. doi: 10.1093/nar/gkx275.


Loss of tumour-specific ATM protein expression is an independent prognostic factor in early resected NSCLC.

Petersen LF, Klimowicz AC, Otsuka S, Elegbede AA, Petrillo SK, Williamson T, Williamson CT, Konno M, Lees-Miller SP, Hao D, Morris D, Magliocco AM, Bebb DG.

Oncotarget. 2017 Jun 13;8(24):38326-38336. doi: 10.18632/oncotarget.16215.


Recruitment of PP1 to the centrosomal scaffold protein CEP192.

Nasa I, Trinkle-Mulcahy L, Douglas P, Chaudhuri S, Lees-Miller SP, Lee KS, Moorhead GB.

Biochem Biophys Res Commun. 2017 Mar 18;484(4):864-870. doi: 10.1016/j.bbrc.2017.02.004. Epub 2017 Feb 8.


ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib.

Wang C, Jette N, Moussienko D, Bebb DG, Lees-Miller SP.

Transl Oncol. 2017 Apr;10(2):190-196. doi: 10.1016/j.tranon.2017.01.007. Epub 2017 Feb 6.


Nanospray HX-MS configuration for structural interrogation of large protein systems.

Sheff JG, Hepburn M, Yu Y, Lees-Miller SP, Schriemer DC.

Analyst. 2017 Mar 13;142(6):904-910. doi: 10.1039/c6an02707e.


Expression of DNA damage response proteins in cervical cancer patients treated with radical chemoradiotherapy.

Ho CK, Kornaga EN, Klimowicz AC, Enwere EK, Dean M, Bebb GD, Phan T, Ghatage P, Magliocco AM, Lees-Miller SP, Doll CM.

Gynecol Oncol. 2017 Apr;145(1):176-184. doi: 10.1016/j.ygyno.2016.12.025. Epub 2017 Jan 26.


Significance of Co-expression of Epidermal Growth Factor Receptor and Ki67 on Clinical Outcome in Patients With Anal Cancer Treated With Chemoradiotherapy: An Analysis of NRG Oncology RTOG 9811.

Doll CM, Moughan J, Klimowicz A, Ho CK, Kornaga EN, Lees-Miller SP, Ajani JA, Crane CH, Kachnic LA, Okawara GS, Berk LB, Roof KS, Becker MJ, Grisell DL, Ellis RJ, Sperduto PW, Marsa GW, Guha C, Magliocco AM.

Int J Radiat Oncol Biol Phys. 2017 Mar 1;97(3):554-562. doi: 10.1016/j.ijrobp.2016.11.021. Epub 2016 Nov 23.


Expression of PD-L1 and presence of CD8-positive T cells in pre-treatment specimens of locally advanced cervical cancer.

Enwere EK, Kornaga EN, Dean M, Koulis TA, Phan T, Kalantarian M, Köbel M, Ghatage P, Magliocco AM, Lees-Miller SP, Doll CM.

Mod Pathol. 2017 Apr;30(4):577-586. doi: 10.1038/modpathol.2016.221. Epub 2017 Jan 6.


An Intrinsically Disordered APLF Links Ku, DNA-PKcs, and XRCC4-DNA Ligase IV in an Extended Flexible Non-homologous End Joining Complex.

Hammel M, Yu Y, Radhakrishnan SK, Chokshi C, Tsai MS, Matsumoto Y, Kuzdovich M, Remesh SG, Fang S, Tomkinson AE, Lees-Miller SP, Tainer JA.

J Biol Chem. 2016 Dec 30;291(53):26987-27006. doi: 10.1074/jbc.M116.751867. Epub 2016 Nov 14.


Low Ki67/high ATM protein expression in malignant tumors predicts favorable prognosis in a retrospective study of early stage hormone receptor positive breast cancer.

Feng X, Li H, Kornaga EN, Dean M, Lees-Miller SP, Riabowol K, Magliocco AM, Morris D, Watson PH, Enwere EK, Bebb G, Paterson A.

Oncotarget. 2016 Dec 27;7(52):85798-85812. doi: 10.18632/oncotarget.12622.


Phosphatidyl inositol-3 kinase (PIK3CA) E545K mutation confers cisplatin resistance and a migratory phenotype in cervical cancer cells.

Arjumand W, Merry CD, Wang C, Saba E, McIntyre JB, Fang S, Kornaga E, Ghatage P, Doll CM, Lees-Miller SP.

Oncotarget. 2016 Dec 13;7(50):82424-82439. doi: 10.18632/oncotarget.10955.


Scaffold attachment factor A (SAF-A) and Ku temporally regulate repair of radiation-induced clustered genome lesions.

Hegde ML, Dutta A, Yang C, Mantha AK, Hegde PM, Pandey A, Sengupta S, Yu Y, Calsou P, Chen D, Lees-Miller SP, Mitra S.

Oncotarget. 2016 Aug 23;7(34):54430-54444. doi: 10.18632/oncotarget.9914.


Noncoding RNA joins Ku and DNA-PKcs for DNA-break resistance in breast cancer.

Lees-Miller SP, Beattie TL, Tainer JA.

Nat Struct Mol Biol. 2016 Jun 7;23(6):509-10. doi: 10.1038/nsmb.3240. No abstract available.


Fumarate in DNA repair.

Lees-Miller SP.

Nat Cell Biol. 2015 Sep;17(9):1096-7. doi: 10.1038/ncb3232.


Phosphorylation of SAF-A/hnRNP-U Serine 59 by Polo-Like Kinase 1 Is Required for Mitosis.

Douglas P, Ye R, Morrice N, Britton S, Trinkle-Mulcahy L, Lees-Miller SP.

Mol Cell Biol. 2015 Aug;35(15):2699-713. doi: 10.1128/MCB.01312-14. Epub 2015 May 18.

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