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Glycoprotein V is a relevant immune target in patients with immune thrombocytopenia.

Vollenberg R, Jouni R, Norris PAA, Burg-Roderfeld M, Cooper N, Rummel MJ, Bein G, Marini I, Bayat B, Burack R, Lazarus AH, Bakchoul T, Sachs UJ.

Haematologica. 2019 Jun;104(6):1237-1243. doi: 10.3324/haematol.2018.211086. Epub 2019 Mar 28.


Antiplatelet antibody-induced thrombocytopenia does not correlate with megakaryocyte abnormalities in murine immune thrombocytopenia.

Guo L, Kapur R, Aslam R, Hunt K, Hou Y, Zufferey A, Speck ER, Rondina MT, Lazarus AH, Ni H, Semple JW.

Scand J Immunol. 2018 Jul;88(1):e12678. doi: 10.1111/sji.12678.


GPIbα is required for platelet-mediated hepatic thrombopoietin generation.

Xu M, Li J, Neves MAD, Zhu G, Carrim N, Yu R, Gupta S, Marshall J, Rotstein O, Peng J, Hou M, Kunishima S, Ware J, Branch DR, Lazarus AH, Ruggeri ZM, Freedman J, Ni H.

Blood. 2018 Aug 9;132(6):622-634. doi: 10.1182/blood-2017-12-820779. Epub 2018 May 24.


Anti-RhD reduces levels of detectable RhD antigen following anti-RhD infusion.

Sullivan HC, Arthur CM, Thompson L, Patel SR, Stowell SR, Hendrickson JE, Lazarus AH.

Transfusion. 2018 Feb;58(2):542-544. doi: 10.1111/trf.14452. No abstract available.


Erythrocyte Saturation with IgG Is Required for Inducing Antibody-Mediated Immune Suppression and Impacts Both Erythrocyte Clearance and Antigen-Modulation Mechanisms.

Cruz-Leal Y, Marjoram D, Lazarus AH.

J Immunol. 2018 Feb 15;200(4):1295-1305. doi: 10.4049/jimmunol.1700874. Epub 2018 Jan 22.


Red blood cell antibody-induced anemia causes differential degrees of tissue hypoxia in kidney and brain.

Mistry N, Mazer CD, Sled JG, Lazarus AH, Cahill LS, Solish M, Zhou YQ, Romanova N, Hare AGM, Doctor A, Fisher JA, Brunt KR, Simpson JA, Hare GMT.

Am J Physiol Regul Integr Comp Physiol. 2018 Apr 1;314(4):R611-R622. doi: 10.1152/ajpregu.00182.2017. Epub 2018 Jan 10.


Immunoglobulin G Fc glycans are not essential for antibody-mediated immune suppression to murine erythrocytes.

Marjoram D, Cruz-Leal Y, Bernardo L, Le NPL, Crispin M, Yu X, Uchikawa M, Lazarus AH.

Blood. 2017 Dec 28;130(26):2902-2905. doi: 10.1182/blood-2017-06-793729. Epub 2017 Nov 6. No abstract available.


Prevention of hemolytic disease of the fetus and newborn: what have we learned from animal models?

Cruz-Leal Y, Marjoram D, Lazarus AH.

Curr Opin Hematol. 2017 Nov;24(6):536-543. doi: 10.1097/MOH.0000000000000374. Review.


Antibody-mediated immune suppression is improved when blends of anti-RBC monoclonal antibodies are used in mice.

Bernardo L, Amash A, Marjoram D, Lazarus AH.

Blood. 2016 Aug 25;128(8):1076-80. doi: 10.1182/blood-2016-01-692178. Epub 2016 Jun 21.


Mechanistic properties of intravenous immunoglobulin in murine immune thrombocytopenia: support for FcγRIIB falls by the wayside.

Crow AR, Lazarus AH.

Semin Hematol. 2016 Apr;53 Suppl 1:S20-2. doi: 10.1053/j.seminhematol.2016.04.007. Epub 2016 Apr 6.


CD44 Antibody Inhibition of Macrophage Phagocytosis Targets Fcγ Receptor- and Complement Receptor 3-Dependent Mechanisms.

Amash A, Wang L, Wang Y, Bhakta V, Fairn GD, Hou M, Peng J, Sheffield WP, Lazarus AH.

J Immunol. 2016 Apr 15;196(8):3331-40. doi: 10.4049/jimmunol.1502198. Epub 2016 Mar 4.


Targeting FcγRs to treat antibody-dependent autoimmunity.

Yu X, Lazarus AH.

Autoimmun Rev. 2016 Jun;15(6):510-2. doi: 10.1016/j.autrev.2016.02.006. Epub 2016 Feb 12. Review.


CD20+ B-cell depletion therapy suppresses murine CD8+ T-cell-mediated immune thrombocytopenia.

Guo L, Kapur R, Aslam R, Speck ER, Zufferey A, Zhao Y, Kim M, Lazarus AH, Ni H, Semple JW.

Blood. 2016 Feb 11;127(6):735-8. doi: 10.1182/blood-2015-06-655126. Epub 2015 Nov 10.


Monovalent Fc receptor blockade by an anti-Fcγ receptor/albumin fusion protein ameliorates murine ITP with abrogated toxicity.

Yu X, Menard M, Prechl J, Bhakta V, Sheffield WP, Lazarus AH.

Blood. 2016 Jan 7;127(1):132-8. doi: 10.1182/blood-2015-08-664656. Epub 2015 Oct 23.


IgG-Mediated Immune Suppression to Erythrocytes by Polyclonal Antibodies Can Occur in the Absence of Activating or Inhibitory Fcγ Receptors in a Full Mouse Model.

Bernardo L, Yu H, Amash A, Zimring JC, Lazarus AH.

J Immunol. 2015 Sep 1;195(5):2224-30. doi: 10.4049/jimmunol.1500790. Epub 2015 Jul 17.


CD8+ T cells are predominantly protective and required for effective steroid therapy in murine models of immune thrombocytopenia.

Ma L, Simpson E, Li J, Xuan M, Xu M, Baker L, Shi Y, Yougbaré I, Wang X, Zhu G, Chen P, Prud'homme GJ, Lazarus AH, Freedman J, Ni H.

Blood. 2015 Jul 9;126(2):247-56. doi: 10.1182/blood-2015-03-635417. Epub 2015 Jun 2.


A monoclonal antibody with anti-D-like activity in murine immune thrombocytopenia requires Fc domain function for immune thrombocytopenia ameliorative effects.

Yu X, Menard M, Seabright G, Crispin M, Lazarus AH.

Transfusion. 2015 Jun;55(6 Pt 2):1501-11. doi: 10.1111/trf.13032. Epub 2015 Mar 6.


RhD Specific Antibodies Are Not Detectable in HLA-DRB1(*)1501 Mice Challenged with Human RhD Positive Erythrocytes.

Bernardo L, Denomme GA, Shah K, Lazarus AH.

Adv Hematol. 2014;2014:470242. doi: 10.1155/2014/470242. Epub 2014 Dec 31.


CD44 antibody-mediated amelioration of murine immune thrombocytopenia (ITP): mouse background determines the effect of FcγRIIb genetic disruption.

Crow AR, Amash A, Lazarus AH.

Transfusion. 2015 Jun;55(6 Pt 2):1492-500. doi: 10.1111/trf.12957. Epub 2014 Dec 15.


Antibody-mediated immune suppression of erythrocyte alloimmunization can occur independently from red cell clearance or epitope masking in a murine model.

Yu H, Stowell SR, Bernardo L, Hendrickson JE, Zimring JC, Amash A, Uchikawa M, Lazarus AH.

J Immunol. 2014 Sep 15;193(6):2902-10. doi: 10.4049/jimmunol.1302287. Epub 2014 Aug 13.

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