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Items: 1 to 20 of 31

1.

Evaluation of Carbazeran 4-Oxidation and O6-Benzylguanine 8-Oxidation as Catalytic Markers of Human Aldehyde Oxidase: Impact of Cytosolic Contamination of Liver Microsomes.

Xie J, Saburulla NF, Chen S, Wong SY, Yap ZP, Zhang LH, Lau AJ.

Drug Metab Dispos. 2018 Oct 18. pii: dmd.118.082099. doi: 10.1124/dmd.118.082099. [Epub ahead of print]

PMID:
30337443
2.

Identification of Galeterone and Abiraterone as Inhibitors of Dehydroepiandrosterone Sulfonation Catalyzed by Human Hepatic Cytosol, SULT2A1, SULT2B1b, and SULT1E1.

Yip CKY, Bansal S, Wong SY, Lau AJ.

Drug Metab Dispos. 2018 Apr;46(4):470-482. doi: 10.1124/dmd.117.078980. Epub 2018 Feb 7.

PMID:
29436390
3.

Comparative analysis of ginsenosides in human glucocorticoid receptor binding, transactivation, and transrepression.

Hu C, Lau AJ, Wang R, Chang TKH.

Eur J Pharmacol. 2017 Nov 15;815:501-511. doi: 10.1016/j.ejphar.2017.10.019. Epub 2017 Oct 12.

PMID:
29031898
4.

Differential activation of pregnane X receptor by carnosic acid, carnosol, ursolic acid, and rosmarinic acid.

Seow CL, Lau AJ.

Pharmacol Res. 2017 Jun;120:23-33. doi: 10.1016/j.phrs.2017.03.007. Epub 2017 Mar 10.

PMID:
28288941
5.

Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation.

Garg A, Zhao A, Erickson SL, Mukherjee S, Lau AJ, Alston L, Chang TK, Mani S, Hirota SA.

J Pharmacol Exp Ther. 2016 Oct;359(1):91-101. doi: 10.1124/jpet.116.234096. Epub 2016 Jul 20.

6.

An ultra-high performance liquid chromatography-tandem mass spectrometric assay for quantifying 3-ketocholanoic acid: Application to the human liver microsomal CYP3A-dependent lithocholic acid 3-oxidation assay.

Bansal S, Chai SF, Lau AJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Jun 15;1023-1024:1-8. doi: 10.1016/j.jchromb.2016.04.039. Epub 2016 Apr 27.

PMID:
27153105
7.

Cell-based and in silico evidence against quercetin and structurally-related flavonols as activators of vitamin D receptor.

Lau AJ, Politi R, Yang G, Chang TK.

J Steroid Biochem Mol Biol. 2016 Oct;163:59-67. doi: 10.1016/j.jsbmb.2016.03.039. Epub 2016 Apr 1.

PMID:
27041117
8.

Fast and sensitive quantification of human liver cytosolic lithocholic acid sulfation using ultra-high performance liquid chromatography-tandem mass spectrometry.

Bansal S, Lau AJ.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Feb 1;1011:171-8. doi: 10.1016/j.jchromb.2015.12.063. Epub 2016 Jan 4.

PMID:
26773894
9.

Human liver cytosolic sulfotransferase 2A1-dependent dehydroepiandrosterone sulfation assay by ultra-high performance liquid chromatography-tandem mass spectrometry.

Bansal S, Lau AJ.

J Pharm Biomed Anal. 2016 Feb 20;120:261-9. doi: 10.1016/j.jpba.2015.12.029. Epub 2015 Dec 22.

PMID:
26760244
10.

Meclizine, a pregnane X receptor agonist, is a direct inhibitor and mechanism-based inactivator of human cytochrome P450 3A.

Foo WY, Tay HY, Chan EC, Lau AJ.

Biochem Pharmacol. 2015 Oct 1;97(3):320-30. doi: 10.1016/j.bcp.2015.07.036. Epub 2015 Jul 31.

PMID:
26239802
11.

3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease.

Lau AJ, Chang TK.

Pharmacol Res. 2015 Oct;100:64-72. doi: 10.1016/j.phrs.2015.07.031. Epub 2015 Jul 31.

PMID:
26238175
12.

Differential activation of human constitutive androstane receptor and its SV23 and SV24 splice variants by rilpivirine and etravirine.

Sharma D, Lau AJ, Sherman MA, Chang TK.

Br J Pharmacol. 2015 Mar;172(5):1263-76. doi: 10.1111/bph.12997. Epub 2015 Feb 10.

13.

Brief reports: Lysosomal cross-correction by hematopoietic stem cell-derived macrophages via tunneling nanotubes.

Naphade S, Sharma J, Gaide Chevronnay HP, Shook MA, Yeagy BA, Rocca CJ, Ur SN, Lau AJ, Courtoy PJ, Cherqui S.

Stem Cells. 2015 Jan;33(1):301-9. doi: 10.1002/stem.1835.

14.
16.

Agonism of human pregnane X receptor by rilpivirine and etravirine: comparison with first generation non-nucleoside reverse transcriptase inhibitors.

Sharma D, Lau AJ, Sherman MA, Chang TK.

Biochem Pharmacol. 2013 Jun 1;85(11):1700-11. doi: 10.1016/j.bcp.2013.04.002. Epub 2013 Apr 9.

PMID:
23583259
17.

Evaluation of Ginkgo biloba extract as an activator of human glucocorticoid receptor.

Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TK.

J Ethnopharmacol. 2013 Jan 30;145(2):670-5. doi: 10.1016/j.jep.2012.11.038. Epub 2012 Dec 5.

PMID:
23220176
18.

Selective agonism of human pregnane X receptor by individual ginkgolides.

Lau AJ, Yang G, Yap CW, Chang TK.

Drug Metab Dispos. 2012 Jun;40(6):1113-21. doi: 10.1124/dmd.112.045013. Epub 2012 Mar 5.

19.

Species-dependent and receptor-selective action of bilobalide on the function of constitutive androstane receptor and pregnane X receptor.

Lau AJ, Yang G, Rajaraman G, Baucom CC, Chang TK.

Drug Metab Dispos. 2012 Jan;40(1):178-86. doi: 10.1124/dmd.111.042879. Epub 2011 Oct 21.

20.

Isoform-selective activation of human constitutive androstane receptor by Ginkgo biloba extract: functional analysis of the SV23, SV24, and SV25 splice variants.

Lau AJ, Yang G, Chang TK.

J Pharmacol Exp Ther. 2011 Nov;339(2):704-15. doi: 10.1124/jpet.111.186130. Epub 2011 Aug 23.

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