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Items: 1 to 20 of 35


Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors.

Holt MC, Assar Z, Beheshti Zavareh R, Lin L, Anglin J, Mashadova O, Haldar D, Mullarky E, Kremer DM, Cantley LC, Kimmelman AC, Stein AJ, Lairson LL, Lyssiotis CA.

Biochemistry. 2018 Nov 12. doi: 10.1021/acs.biochem.8b00914. [Epub ahead of print]


A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling.

Bollong MJ, Lee G, Coukos JS, Yun H, Zambaldo C, Chang JW, Chin EN, Ahmad I, Chatterjee AK, Lairson LL, Schultz PG, Moellering RE.

Nature. 2018 Oct;562(7728):600-604. doi: 10.1038/s41586-018-0622-0. Epub 2018 Oct 15.


Discovery and optimization of aspartate aminotransferase 1 inhibitors to target redox balance in pancreatic ductal adenocarcinoma.

Anglin J, Zavareh RB, Sander PN, Haldar D, Mullarky E, Cantley LC, Kimmelman AC, Lyssiotis CA, Lairson LL.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2675-2678. doi: 10.1016/j.bmcl.2018.04.061. Epub 2018 Apr 27.


Metabolomics-based discovery of a metabolite that enhances oligodendrocyte maturation.

Beyer BA, Fang M, Sadrian B, Montenegro-Burke JR, Plaisted WC, Kok BPC, Saez E, Kondo T, Siuzdak G, Lairson LL.

Nat Chem Biol. 2018 Jan;14(1):22-28. doi: 10.1038/nchembio.2517. Epub 2017 Nov 13.


A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers.

Bollong MJ, Pietilä M, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9903-E9912. doi: 10.1073/pnas.1716009114. Epub 2017 Oct 30.


Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics.

Lum KM, Sato Y, Beyer BA, Plaisted WC, Anglin JL, Lairson LL, Cravatt BF.

ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.


Systems biology guided by XCMS Online metabolomics.

Huan T, Forsberg EM, Rinehart D, Johnson CH, Ivanisevic J, Benton HP, Fang M, Aisporna A, Hilmers B, Poole FL, Thorgersen MP, Adams MWW, Krantz G, Fields MW, Robbins PD, Niedernhofer LJ, Ideker T, Majumder EL, Wall JD, Rattray NJW, Goodacre R, Lairson LL, Siuzdak G.

Nat Methods. 2017 Apr 27;14(5):461-462. doi: 10.1038/nmeth.4260. No abstract available.


Small molecule-mediated inhibition of myofibroblast transdifferentiation for the treatment of fibrosis.

Bollong MJ, Yang B, Vergani N, Beyer BA, Chin EN, Zambaldo C, Wang D, Chatterjee AK, Lairson LL, Schultz PG.

Proc Natl Acad Sci U S A. 2017 May 2;114(18):4679-4684. doi: 10.1073/pnas.1702750114. Epub 2017 Apr 17.


Data Streaming for Metabolomics: Accelerating Data Processing and Analysis from Days to Minutes.

Montenegro-Burke JR, Aisporna AE, Benton HP, Rinehart D, Fang M, Huan T, Warth B, Forsberg E, Abe BT, Ivanisevic J, Wolan DW, Teyton L, Lairson L, Siuzdak G.

Anal Chem. 2017 Jan 17;89(2):1254-1259. doi: 10.1021/acs.analchem.6b03890. Epub 2017 Jan 3.


A novel small-molecule inhibitor of 3-phosphoglycerate dehydrogenase.

Mullarky E, Lairson LL, Cantley LC, Lyssiotis CA.

Mol Cell Oncol. 2016 Mar 30;3(4):e1164280. doi: 10.1080/23723556.2016.1164280. eCollection 2016 Jul.


Smartphone Analytics: Mobilizing the Lab into the Cloud for Omic-Scale Analyses.

Montenegro-Burke JR, Phommavongsay T, Aisporna AE, Huan T, Rinehart D, Forsberg E, Poole FL, Thorgersen MP, Adams MW, Krantz G, Fields MW, Northen TR, Robbins PD, Niedernhofer LJ, Lairson L, Benton HP, Siuzdak G.

Anal Chem. 2016 Oct 4;88(19):9753-9758. Epub 2016 Sep 15.


High-Throughput Screening Uncovers Novel Botulinum Neurotoxin Inhibitor Chemotypes.

Bompiani KM, Caglič D, Krutein MC, Benoni G, Hrones M, Lairson LL, Bian H, Smith GR, Dickerson TJ.

ACS Comb Sci. 2016 Aug 8;18(8):461-74. doi: 10.1021/acscombsci.6b00033. Epub 2016 Jul 20.


Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.

Mullarky E, Lucki NC, Beheshti Zavareh R, Anglin JL, Gomes AP, Nicolay BN, Wong JC, Christen S, Takahashi H, Singh PK, Blenis J, Warren JD, Fendt SM, Asara JM, DeNicola GM, Lyssiotis CA, Lairson LL, Cantley LC.

Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1778-83. doi: 10.1073/pnas.1521548113. Epub 2016 Feb 1. Erratum in: Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):E1585.


A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer.

Bollong MJ, Yun H, Sherwood L, Woods AK, Lairson LL, Schultz PG.

ACS Chem Biol. 2015 Oct 16;10(10):2193-8. doi: 10.1021/acschembio.5b00448. Epub 2015 Aug 17.


Identification of clinically viable quinolinol inhibitors of botulinum neurotoxin A light chain.

Caglič D, Krutein MC, Bompiani KM, Barlow DJ, Benoni G, Pelletier JC, Reitz AB, Lairson LL, Houseknecht KL, Smith GR, Dickerson TJ.

J Med Chem. 2014 Feb 13;57(3):669-76. doi: 10.1021/jm4012164. Epub 2014 Jan 15.


A regenerative approach to the treatment of multiple sclerosis.

Deshmukh VA, Tardif V, Lyssiotis CA, Green CC, Kerman B, Kim HJ, Padmanabhan K, Swoboda JG, Ahmad I, Kondo T, Gage FH, Theofilopoulos AN, Lawson BR, Schultz PG, Lairson LL.

Nature. 2013 Oct 17;502(7471):327-332. doi: 10.1038/nature12647. Epub 2013 Oct 9.


Small molecule-based approaches to adult stem cell therapies.

Lairson LL, Lyssiotis CA, Zhu S, Schultz PG.

Annu Rev Pharmacol Toxicol. 2013;53:107-25. doi: 10.1146/annurev-pharmtox-011112-140300. Review.


Structural and kinetic analysis of substrate binding to the sialyltransferase Cst-II from Campylobacter jejuni.

Lee HJ, Lairson LL, Rich JR, Lameignere E, Wakarchuk WW, Withers SG, Strynadka NC.

J Biol Chem. 2011 Oct 14;286(41):35922-32. doi: 10.1074/jbc.M111.261172. Epub 2011 Aug 5.


Pan-Src family kinase inhibitors replace Sox2 during the direct reprogramming of somatic cells.

Staerk J, Lyssiotis CA, Medeiro LA, Bollong M, Foreman RK, Zhu S, Garcia M, Gao Q, Bouchez LC, Lairson LL, Charette BD, Supekova L, Janes J, Brinker A, Cho CY, Jaenisch R, Schultz PG.

Angew Chem Int Ed Engl. 2011 Jun 14;50(25):5734-6. doi: 10.1002/anie.201101042. Epub 2011 May 5. No abstract available.


Chemical control of stem cell fate and developmental potential.

Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S, Schultz PG.

Angew Chem Int Ed Engl. 2011 Jan 3;50(1):200-42. doi: 10.1002/anie.201004284. Review.


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