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Items: 1 to 20 of 116


Structural basis for activation of SAGA histone acetyltransferase Gcn5 by partner subunit Ada2.

Sun J, Paduch M, Kim SA, Kramer RM, Barrios AF, Lu V, Luke J, Usatyuk S, Kossiakoff AA, Tan S.

Proc Natl Acad Sci U S A. 2018 Sep 17. pii: 201805343. doi: 10.1073/pnas.1805343115. [Epub ahead of print]


Structural basis for activation of voltage sensor domains in an ion channel TPC1.

Kintzer AF, Green EM, Dominik PK, Bridges M, Armache JP, Deneka D, Kim SS, Hubbell W, Kossiakoff AA, Cheng Y, Stroud RM.

Proc Natl Acad Sci U S A. 2018 Sep 6. pii: 201805651. doi: 10.1073/pnas.1805651115. [Epub ahead of print]


The structure of the C-terminal domain of the nucleoprotein from the Bundibugyo strain of the Ebola virus in complex with a pan-specific synthetic Fab.

Radwańska MJ, Jaskółowski M, Davydova E, Derewenda U, Miyake T, Engel DA, Kossiakoff AA, Derewenda ZS.

Acta Crystallogr D Struct Biol. 2018 Jul 1;74(Pt 7):681-689. doi: 10.1107/S2059798318007878. Epub 2018 Jun 27.


Publisher Correction: Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.

Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE.

Nature. 2018 Jun 21. doi: 10.1038/s41586-018-0302-0. [Epub ahead of print]


Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.

Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE.

Nature. 2018 Jun;558(7711):553-558. doi: 10.1038/s41586-018-0215-y. Epub 2018 Jun 13. Erratum in: Nature. 2018 Jun 21;:.


Reply to Kang and Brooks: Comment on the calculations in protein thermodynamics.

Kossiakoff AA, Mukherjee S, Horn JR.

J Biol Chem. 2018 Apr 6;293(14):5063. doi: 10.1074/jbc.RL118.002471. No abstract available.


Ensemble cryoEM elucidates the mechanism of insulin capture and degradation by human insulin degrading enzyme.

Zhang Z, Liang WG, Bailey LJ, Tan YZ, Wei H, Wang A, Farcasanu M, Woods VA, McCord LA, Lee D, Shang W, Deprez-Poulain R, Deprez B, Liu DR, Koide A, Koide S, Kossiakoff AA, Li S, Carragher B, Potter CS, Tang WJ.

Elife. 2018 Mar 29;7. pii: e33572. doi: 10.7554/eLife.33572.


Engineered synthetic antibodies as probes to quantify the energetic contributions of ligand binding to conformational changes in proteins.

Mukherjee S, Griffin DH, Horn JR, Rizk SS, Nocula-Lugowska M, Malmqvist M, Kim SS, Kossiakoff AA.

J Biol Chem. 2018 Feb 23;293(8):2815-2828. doi: 10.1074/jbc.RA117.000656. Epub 2018 Jan 10.


Locking the Elbow: Improved Antibody Fab Fragments as Chaperones for Structure Determination.

Bailey LJ, Sheehy KM, Dominik PK, Liang WG, Rui H, Clark M, Jaskolowski M, Kim Y, Deneka D, Tang WJ, Kossiakoff AA.

J Mol Biol. 2018 Feb 2;430(3):337-347. doi: 10.1016/j.jmb.2017.12.012. Epub 2017 Dec 19.


Targeted rescue of cancer-associated IDH1 mutant activity using an engineered synthetic antibody.

Rizk SS, Mukherjee S, Koide A, Koide S, Kossiakoff AA.

Sci Rep. 2017 Apr 3;7(1):556. doi: 10.1038/s41598-017-00728-1.


Generating Conformation and Complex-Specific Synthetic Antibodies.

Paduch M, Kossiakoff AA.

Methods Mol Biol. 2017;1575:93-119. doi: 10.1007/978-1-4939-6857-2_6.


Prolactin Receptor-Mediated Internalization of Imaging Agents Detects Epithelial Ovarian Cancer with Enhanced Sensitivity and Specificity.

Sundaram KM, Zhang Y, Mitra AK, Kouadio JK, Gwin K, Kossiakoff AA, Roman BB, Lengyel E, Piccirilli JA.

Cancer Res. 2017 Apr 1;77(7):1684-1696. doi: 10.1158/0008-5472.CAN-16-1454. Epub 2017 Feb 15.


The Preserved HTH-Docking Cleft of HIV-1 Integrase Is Functionally Critical.

Galilee M, Britan-Rosich E, Griner SL, Uysal S, Baumgärtel V, Lamb DC, Kossiakoff AA, Kotler M, Stroud RM, Marx A, Alian A.

Structure. 2016 Nov 1;24(11):1936-1946. doi: 10.1016/j.str.2016.08.015. Epub 2016 Sep 29.


Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.

Shao Y, Huang H, Qin D, Li NS, Koide A, Staley JP, Koide S, Kossiakoff AA, Piccirilli JA.

J Mol Biol. 2016 Oct 9;428(20):4100-4114. doi: 10.1016/j.jmb.2016.08.029. Epub 2016 Sep 2.


A polar ring endows improved specificity to an antibody fragment.

Schaefer ZP, Bailey LJ, Kossiakoff AA.

Protein Sci. 2016 Jul;25(7):1290-8. doi: 10.1002/pro.2888. Epub 2016 Mar 9.


Conformational Chaperones for Structural Studies of Membrane Proteins Using Antibody Phage Display with Nanodiscs.

Dominik PK, Borowska MT, Dalmas O, Kim SS, Perozo E, Keenan RJ, Kossiakoff AA.

Structure. 2016 Feb 2;24(2):300-9. doi: 10.1016/j.str.2015.11.014. Epub 2015 Dec 31.


Optimizing Production of Antigens and Fabs in the Context of Generating Recombinant Antibodies to Human Proteins.

Zhong N, Loppnau P, Seitova A, Ravichandran M, Fenner M, Jain H, Bhattacharya A, Hutchinson A, Paduch M, Lu V, Olszewski M, Kossiakoff AA, Dowdell E, Koide A, Koide S, Huang H, Nadeem V, Sidhu SS, Greenblatt JF, Marcon E, Arrowsmith CH, Edwards AM, Gräslund S.

PLoS One. 2015 Oct 5;10(10):e0139695. doi: 10.1371/journal.pone.0139695. eCollection 2015.


Architecture of the fungal nuclear pore inner ring complex.

Stuwe T, Bley CJ, Thierbach K, Petrovic S, Schilbach S, Mayo DJ, Perriches T, Rundlet EJ, Jeon YE, Collins LN, Huber FM, Lin DH, Paduch M, Koide A, Lu V, Fischer J, Hurt E, Koide S, Kossiakoff AA, Hoelz A.

Science. 2015 Oct 2;350(6256):56-64. doi: 10.1126/science.aac9176. Epub 2015 Aug 27.


A YidC-like Protein in the Archaeal Plasma Membrane.

Borowska MT, Dominik PK, Anghel SA, Kossiakoff AA, Keenan RJ.

Structure. 2015 Sep 1;23(9):1715-1724. doi: 10.1016/j.str.2015.06.025. Epub 2015 Aug 6.


A New Versatile Immobilization Tag Based on the Ultra High Affinity and Reversibility of the Calmodulin-Calmodulin Binding Peptide Interaction.

Mukherjee S, Ura M, Hoey RJ, Kossiakoff AA.

J Mol Biol. 2015 Aug 14;427(16):2707-25. doi: 10.1016/j.jmb.2015.06.018. Epub 2015 Jul 6.

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