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Items: 1 to 20 of 449

1.

Genome-wide gene-environment analyses of major depressive disorder and reported lifetime traumatic experiences in UK Biobank.

Coleman JRI, Peyrot WJ, Purves KL, Davis KAS, Rayner C, Choi SW, Hübel C, Gaspar HA, Kan C, Van der Auwera S, Adams MJ, Lyall DM, Choi KW; on the behalf of Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Dunn EC, Vassos E, Danese A, Maughan B, Grabe HJ, Lewis CM, O'Reilly PF, McIntosh AM, Smith DJ, Wray NR, Hotopf M, Eley TC, Breen G.

Mol Psychiatry. 2020 Jan 23. doi: 10.1038/s41380-019-0546-6. [Epub ahead of print]

PMID:
31969693
2.

The phenotypical implications of immune dysregulation in fragile X syndrome.

Yu KH, Palmer N, Fox K, Prock L, Mandl KD, Kohane IS, Prilutsky D.

Eur J Neurol. 2020 Mar;27(3):590-593. doi: 10.1111/ene.14146. Epub 2020 Jan 17.

PMID:
31953887
3.

Big Data in the Assessment of Pediatric Medication Safety.

McMahon AW, Cooper WO, Brown JS, Carleton B, Doshi-Velez F, Kohane I, Goldman JL, Hoffman MA, Kamaleswaran R, Sakiyama M, Sekine S, Sturkenboom MCJM, Turner MA, Califf RM.

Pediatrics. 2020 Feb;145(2). pii: e20190562. doi: 10.1542/peds.2019-0562. Epub 2020 Jan 14.

PMID:
31937606
4.

The Genetics of the Mood Disorder Spectrum: Genome-wide Association Analyses of More Than 185,000 Cases and 439,000 Controls.

Coleman JRI, Gaspar HA, Bryois J; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Breen G.

Biol Psychiatry. 2019 Nov 1. pii: S0006-3223(19)31813-X. doi: 10.1016/j.biopsych.2019.10.015. [Epub ahead of print]

PMID:
31926635
5.

Meta-analysis of C. elegans single-cell developmental data reveals multi-frequency oscillation in gene activation.

Hutchison L, Berger B, Kohane I.

Bioinformatics. 2019 Dec 20. pii: btz864. doi: 10.1093/bioinformatics/btz864. [Epub ahead of print]

PMID:
31860066
6.

Clinical Concept Embeddings Learned from Massive Sources of Multimodal Medical Data.

Beam AL, Kompa B, Schmaltz A, Fried I, Weber G, Palmer N, Shi X, Cai T, Kohane IS.

Pac Symp Biocomput. 2020;25:295-306.

7.

High-throughput phenotyping with electronic medical record data using a common semi-supervised approach (PheCAP).

Zhang Y, Cai T, Yu S, Cho K, Hong C, Sun J, Huang J, Ho YL, Ananthakrishnan AN, Xia Z, Shaw SY, Gainer V, Castro V, Link N, Honerlaw J, Huang S, Gagnon D, Karlson EW, Plenge RM, Szolovits P, Savova G, Churchill S, O'Donnell C, Murphy SN, Gaziano JM, Kohane I, Cai T, Liao KP.

Nat Protoc. 2019 Dec;14(12):3426-3444. doi: 10.1038/s41596-019-0227-6. Epub 2019 Nov 20.

PMID:
31748751
8.

Making the 'invisible' visible: transforming the detection of intimate partner violence.

Khurana B, Seltzer SE, Kohane IS, Boland GW.

BMJ Qual Saf. 2019 Nov 20. pii: bmjqs-2019-009905. doi: 10.1136/bmjqs-2019-009905. [Epub ahead of print] Review. No abstract available.

PMID:
31748403
9.

Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders.

Andlauer TFM, Guzman-Parra J, Streit F, Strohmaier J, González MJ, Gil Flores S, Cabaleiro Fabeiro FJ, Del Río Noriega F, Perez FP, Haro González J, Orozco Diaz G, de Diego-Otero Y, Moreno-Küstner B, Auburger G, Degenhardt F, Heilmann-Heimbach S, Herms S, Hoffmann P, Frank J, Foo JC, Treutlein J, Witt SH, Cichon S, Kogevinas M; Bipolar Disorder Working Group of the Psychiatric Genomics Consortium; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, Rivas F, Mayoral F, Müller-Myhsok B, Forstner AJ, Nöthen MM, Rietschel M.

Mol Psychiatry. 2019 Nov 11. doi: 10.1038/s41380-019-0558-2. [Epub ahead of print]

PMID:
31712721
10.

Automated grouping of medical codes via multiview banded spectral clustering.

Zhang L, Zhang Y, Cai T, Ahuja Y, He Z, Ho YL, Beam A, Cho K, Carroll R, Denny J, Kohane I, Liao K, Cai T.

J Biomed Inform. 2019 Dec;100:103322. doi: 10.1016/j.jbi.2019.103322. Epub 2019 Oct 28.

PMID:
31672532
11.

Concordance between gene expression in peripheral whole blood and colonic tissue in children with inflammatory bowel disease.

Palmer NP, Silvester JA, Lee JJ, Beam AL, Fried I, Valtchinov VI, Rahimov F, Kong SW, Ghodoussipour S, Hood HC, Bousvaros A, Grand RJ, Kunkel LM, Kohane IS.

PLoS One. 2019 Oct 16;14(10):e0222952. doi: 10.1371/journal.pone.0222952. eCollection 2019.

12.

VarSight: prioritizing clinically reported variants with binary classification algorithms.

Holt JM, Wilk B, Birch CL, Brown DM, Gajapathy M, Moss AC, Sosonkina N, Wilk MA, Anderson JA, Harris JM, Kelly JM, Shaterferdosian F, Uno-Antonison AE, Weborg A; Undiagnosed Diseases Network, Worthey EA.

BMC Bioinformatics. 2019 Oct 15;20(1):496. doi: 10.1186/s12859-019-3026-8.

13.

High-throughput multimodal automated phenotyping (MAP) with application to PheWAS.

Liao KP, Sun J, Cai TA, Link N, Hong C, Huang J, Huffman JE, Gronsbell J, Zhang Y, Ho YL, Castro V, Gainer V, Murphy SN, O'Donnell CJ, Gaziano JM, Cho K, Szolovits P, Kohane IS, Yu S, Cai T.

J Am Med Inform Assoc. 2019 Nov 1;26(11):1255-1262. doi: 10.1093/jamia/ocz066.

PMID:
31613361
14.

Donald A. B. Lindberg (1933-2019).

Kohane I, Berg JM.

Science. 2019 Oct 4;366(6461):37. doi: 10.1126/science.aaz3644. No abstract available.

PMID:
31604294
15.

De Novo Pathogenic Variants in N-cadherin Cause a Syndromic Neurodevelopmental Disorder with Corpus Collosum, Axon, Cardiac, Ocular, and Genital Defects.

Accogli A, Calabretta S, St-Onge J, Boudrahem-Addour N, Dionne-Laporte A, Joset P, Azzarello-Burri S, Rauch A, Krier J, Fieg E, Pallais JC; Undiagnosed Diseases Network, McConkie-Rosell A, McDonald M, Freedman SF, Rivière JB, Lafond-Lapalme J, Simpson BN, Hopkin RJ, Trimouille A, Van-Gils J, Begtrup A, McWalter K, Delphine H, Keren B, Genevieve D, Argilli E, Sherr EH, Severino M, Rouleau GA, Yam PT, Charron F, Srour M.

Am J Hum Genet. 2019 Oct 3;105(4):854-868. doi: 10.1016/j.ajhg.2019.09.005.

PMID:
31585109
16.

Classical Human Leukocyte Antigen Alleles and C4 Haplotypes Are Not Significantly Associated With Depression.

Glanville KP, Coleman JRI, Hanscombe KB, Euesden J, Choi SW, Purves KL, Breen G, Air TM, Andlauer TFM, Baune BT, Binder EB, Blackwood DHR, Boomsma DI, Buttenschøn HN, Colodro-Conde L, Dannlowski U, Direk N, Dunn EC, Forstner AJ, de Geus EJC, Grabe HJ, Hamilton SP, Jones I, Jones LA, Knowles JA, Kutalik Z, Levinson DF, Lewis G, Lind PA, Lucae S, Magnusson PK, McGuffin P, McIntosh AM, Milaneschi Y, Mors O, Mostafavi S, Müller-Myhsok B, Pedersen NL, Penninx BWJH, Potash JB, Preisig M, Ripke S, Shi J, Shyn SI, Smoller JW, Streit F, Sullivan PF, Tiemeier H, Uher R, Van der Auwera S, Weissman MM; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, O'Reilly PF, Lewis CM.

Biol Psychiatry. 2020 Mar 1;87(5):419-430. doi: 10.1016/j.biopsych.2019.06.031. Epub 2019 Aug 5.

17.

Examining the Use of Real-World Evidence in the Regulatory Process.

Beaulieu-Jones BK, Finlayson SG, Yuan W, Altman RB, Kohane IS, Prasad V, Yu KH.

Clin Pharmacol Ther. 2019 Sep 28. doi: 10.1002/cpt.1658. [Epub ahead of print] Review.

PMID:
31562770
18.

A fast divide-and-conquer sparse Cox regression.

Wang Y, Hong C, Palmer N, Di Q, Schwartz J, Kohane I, Cai T.

Biostatistics. 2019 Sep 23. pii: kxz036. doi: 10.1093/biostatistics/kxz036. [Epub ahead of print]

PMID:
31545341
19.

Aberrant mitochondrial function in patient-derived neural cells from CDKL5 deficiency disorder and Rett syndrome.

Jagtap S, Thanos JM, Fu T, Wang J, Lalonde J, Dial TO, Feiglin A, Chen J, Kohane I, Lee JT, Sheridan SD, Perlis RH.

Hum Mol Genet. 2019 Nov 1;28(21):3625-3636. doi: 10.1093/hmg/ddz208.

20.

De Novo Variants in WDR37 Are Associated with Epilepsy, Colobomas, Dysmorphism, Developmental Delay, Intellectual Disability, and Cerebellar Hypoplasia.

Kanca O, Andrews JC, Lee PT, Patel C, Braddock SR, Slavotinek AM, Cohen JS, Gubbels CS, Aldinger KA, Williams J, Indaram M, Fatemi A, Yu TW, Agrawal PB, Vezina G, Simons C, Crawford J, Lau CC; Undiagnosed Diseases Network, Chung WK, Markello TC, Dobyns WB, Adams DR, Gahl WA, Wangler MF, Yamamoto S, Bellen HJ, Malicdan MCV.

Am J Hum Genet. 2019 Sep 5;105(3):672-674. doi: 10.1016/j.ajhg.2019.07.017. No abstract available.

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