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Items: 1 to 20 of 71


MAC inhibitors antagonize the pro-apoptotic effects of tBid and disassemble Bax / Bak oligomers.

Peixoto PM, Teijido O, Mirzalieva O, Dejean LM, Pavlov EV, Antonsson B, Kinnally KW.

J Bioenerg Biomembr. 2017 Feb;49(1):65-74. doi: 10.1007/s10863-015-9635-7. Epub 2015 Dec 23.


Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice.

Karch J, Kwong JQ, Burr AR, Sargent MA, Elrod JW, Peixoto PM, Martinez-Caballero S, Osinska H, Cheng EH, Robbins J, Kinnally KW, Molkentin JD.

Elife. 2013 Aug 27;2:e00772. doi: 10.7554/eLife.00772.


A myosin-Va tail fragment sequesters dynein light chains leading to apoptosis in melanoma cells.

Izidoro-Toledo TC, Borges AC, Araújo DD, Mazzi DP, Nascimento Júnior FO, Sousa JF, Alves CP, Paiva AP, Trindade DM, Patussi EV, Peixoto PM, Kinnally KW, Espreafico EM.

Cell Death Dis. 2013 Mar 21;4:e547. doi: 10.1038/cddis.2013.45.


Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts.

Ryu SY, Beutner G, Kinnally KW, Dirksen RT, Sheu SS.

J Biol Chem. 2011 Jun 17;286(24):21324-9. doi: 10.1074/jbc.C111.245597. Epub 2011 Apr 27.


The therapeutic potential of mitochondrial channels in cancer, ischemia-reperfusion injury, and neurodegeneration.

Peixoto PM, Dejean LM, Kinnally KW.

Mitochondrion. 2012 Jan;12(1):14-23. doi: 10.1016/j.mito.2011.03.003. Epub 2011 Mar 23. Review.


Mitochondrial apoptosis-induced channel (MAC) function triggers a Bax/Bak-dependent bystander effect.

Peixoto PM, Lue JK, Ryu SY, Wroble BN, Sible JC, Kinnally KW.

Am J Pathol. 2011 Jan;178(1):48-54. doi: 10.1016/j.ajpath.2010.11.014. Epub 2010 Dec 23.


Is mPTP the gatekeeper for necrosis, apoptosis, or both?

Kinnally KW, Peixoto PM, Ryu SY, Dejean LM.

Biochim Biophys Acta. 2011 Apr;1813(4):616-22. doi: 10.1016/j.bbamcr.2010.09.013. Epub 2010 Oct 1. Review.


Role of mitochondrial ion channels in cell death.

Ryu SY, Peixoto PM, Teijido O, Dejean LM, Kinnally KW.

Biofactors. 2010 Jul-Aug;36(4):255-63. doi: 10.1002/biof.101. Review.


Mitochondrial ion channels as therapeutic targets.

Peixoto PM, Ryu SY, Kinnally KW.

FEBS Lett. 2010 May 17;584(10):2142-52. doi: 10.1016/j.febslet.2010.02.046. Epub 2010 Feb 20. Review.


Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels.

Ryu SY, Beutner G, Dirksen RT, Kinnally KW, Sheu SS.

FEBS Lett. 2010 May 17;584(10):1948-55. doi: 10.1016/j.febslet.2010.01.032. Epub 2010 Jan 21. Review.


MAC and Bcl-2 family proteins conspire in a deadly plot.

Dejean LM, Ryu SY, Martinez-Caballero S, Teijido O, Peixoto PM, Kinnally KW.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):1231-8. doi: 10.1016/j.bbabio.2010.01.007. Epub 2010 Jan 18. Review.


Mitochondrial apoptosis is amplified through gap junctions.

Peixoto PM, Ryu SY, Pruzansky DP, Kuriakose M, Gilmore A, Kinnally KW.

Biochem Biophys Res Commun. 2009 Dec 4;390(1):38-43. doi: 10.1016/j.bbrc.2009.09.054. Epub 2009 Sep 18.


MAC inhibitors suppress mitochondrial apoptosis.

Peixoto PM, Ryu SY, Bombrun A, Antonsson B, Kinnally KW.

Biochem J. 2009 Oct 12;423(3):381-7. doi: 10.1042/BJ20090664.


Assembly of the mitochondrial apoptosis-induced channel, MAC.

Martinez-Caballero S, Dejean LM, Kinnally MS, Oh KJ, Mannella CA, Kinnally KW.

J Biol Chem. 2009 May 1;284(18):12235-45. doi: 10.1074/jbc.M806610200. Epub 2009 Mar 4.


Reflections on VDAC as a voltage-gated channel and a mitochondrial regulator.

Mannella CA, Kinnally KW.

J Bioenerg Biomembr. 2008 Jun;40(3):149-55. doi: 10.1007/s10863-008-9143-0. Review.


The nuclear receptor interacting factor-3 transcriptional coregulator mediates rapid apoptosis in breast cancer cells through direct and bystander-mediated events.

Das S, Nwachukwu JC, Li D, Vulin AI, Martinez-Caballero S, Kinnally KW, Samuels HH.

Cancer Res. 2007 Feb 15;67(4):1775-82. Erratum in: Cancer Res. 2007 May 1;67(9):4535.


A tale of two mitochondrial channels, MAC and PTP, in apoptosis.

Kinnally KW, Antonsson B.

Apoptosis. 2007 May;12(5):857-68. Review.


A fluorescence assay for peptide translocation into mitochondria.

Martinez-Caballero S, Peixoto PM, Kinnally KW, Campo ML.

Anal Biochem. 2007 Mar 1;362(1):76-82. Epub 2007 Jan 22.


Tim17p regulates the twin pore structure and voltage gating of the mitochondrial protein import complex TIM23.

Martinez-Caballero S, Grigoriev SM, Herrmann JM, Campo ML, Kinnally KW.

J Biol Chem. 2007 Feb 9;282(6):3584-93. Epub 2006 Dec 5.

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