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Items: 1 to 20 of 38


Editorial: Novel Concepts in Cardiac Energy Metabolism: From Biology to Disease.

Pulinilkunnil T, Kienesberger P, Nagendran J.

Front Cardiovasc Med. 2019 Jul 12;6:97. doi: 10.3389/fcvm.2019.00097. eCollection 2019. No abstract available.


Impact of Obesity on Postoperative Outcomes following cardiac Surgery (The OPOS study): rationale and design of an investigator-initiated prospective study.

Aguiar C, MacLeod J, Yip A, Melville S, Légaré JF, Pulinilkunnil T, Kienesberger P, Brunt K, Hassan A.

BMJ Open. 2019 Mar 3;9(3):e023418. doi: 10.1136/bmjopen-2018-023418.


Autotaxin-LPA signaling contributes to obesity-induced insulin resistance in muscle and impairs mitochondrial metabolism.

D'Souza K, Nzirorera C, Cowie AM, Varghese GP, Trivedi P, Eichmann TO, Biswas D, Touaibia M, Morris AJ, Aidinis V, Kane DA, Pulinilkunnil T, Kienesberger PC.

J Lipid Res. 2018 Oct;59(10):1805-1817. doi: 10.1194/jlr.M082008. Epub 2018 Aug 2.


Lysophosphatidic Acid Signaling in Obesity and Insulin Resistance.

D'Souza K, Paramel GV, Kienesberger PC.

Nutrients. 2018 Mar 23;10(4). pii: E399. doi: 10.3390/nu10040399. Review.


Lysophosphatidic acid receptor mRNA levels in heart and white adipose tissue are associated with obesity in mice and humans.

Brown A, Hossain I, Perez LJ, Nzirorera C, Tozer K, D'Souza K, Trivedi PC, Aguiar C, Yip AM, Shea J, Brunt KR, Legare JF, Hassan A, Pulinilkunnil T, Kienesberger PC.

PLoS One. 2017 Dec 13;12(12):e0189402. doi: 10.1371/journal.pone.0189402. eCollection 2017.


Validation of optimal reference genes for quantitative real time PCR in muscle and adipose tissue for obesity and diabetes research.

Perez LJ, Rios L, Trivedi P, D'Souza K, Cowie A, Nzirorera C, Webster D, Brunt K, Legare JF, Hassan A, Kienesberger PC, Pulinilkunnil T.

Sci Rep. 2017 Jun 15;7(1):3612. doi: 10.1038/s41598-017-03730-9.


Dieldrin Augments mTOR Signaling and Regulates Genes Associated with Cardiovascular Disease in the Adult Zebrafish Heart (Danio rerio).

Slade L, Cowie A, Martyniuk CJ, Kienesberger PC, Pulinilkunnil T.

J Pharmacol Exp Ther. 2017 Jun;361(3):375-385. doi: 10.1124/jpet.116.239806. Epub 2017 Apr 6.


Changes in Circulating Monocyte Subsets (CD16 Expression) and Neutrophil-to-Lymphocyte Ratio Observed in Patients Undergoing Cardiac Surgery.

Gawdat K, Legere S, Wong C, Myers T, Marshall JS, Hassan A, Brunt KR, Kienesberger PC, Pulinilkunnil T, Legare JF.

Front Cardiovasc Med. 2017 Mar 15;4:12. doi: 10.3389/fcvm.2017.00012. eCollection 2017.


Autotaxin Is Regulated by Glucose and Insulin in Adipocytes.

D'Souza K, Kane DA, Touaibia M, Kershaw EE, Pulinilkunnil T, Kienesberger PC.

Endocrinology. 2017 Apr 1;158(4):791-803. doi: 10.1210/en.2017-00035.


Doxorubicin impairs cardiomyocyte viability by suppressing transcription factor EB expression and disrupting autophagy.

Bartlett JJ, Trivedi PC, Yeung P, Kienesberger PC, Pulinilkunnil T.

Biochem J. 2016 Nov 1;473(21):3769-3789. Epub 2016 Aug 3.


Glucolipotoxicity diminishes cardiomyocyte TFEB and inhibits lysosomal autophagy during obesity and diabetes.

Trivedi PC, Bartlett JJ, Perez LJ, Brunt KR, Legare JF, Hassan A, Kienesberger PC, Pulinilkunnil T.

Biochim Biophys Acta. 2016 Dec;1861(12 Pt A):1893-1910. doi: 10.1016/j.bbalip.2016.09.004. Epub 2016 Sep 9.


New Atglistatin closely related analogues: Synthesis and structure-activity relationship towards adipose triglyceride lipase inhibition.

Roy PP, D'Souza K, Cuperlovic-Culf M, Kienesberger PC, Touaibia M.

Eur J Med Chem. 2016 Aug 8;118:290-8. doi: 10.1016/j.ejmech.2016.04.021. Epub 2016 Apr 10.


Lipid metabolism and signaling in cardiac lipotoxicity.

D'Souza K, Nzirorera C, Kienesberger PC.

Biochim Biophys Acta. 2016 Oct;1861(10):1513-24. doi: 10.1016/j.bbalip.2016.02.016. Epub 2016 Feb 23. Review.


Serum Autotaxin/ENPP2 correlates with insulin resistance in older humans with obesity.

Reeves VL, Trybula JS, Wills RC, Goodpaster BH, Dubé JJ, Kienesberger PC, Kershaw EE.

Obesity (Silver Spring). 2015 Dec;23(12):2371-6. doi: 10.1002/oby.21232. Epub 2015 Nov 2.


Serum autotaxin is independently associated with hepatic steatosis in women with severe obesity.

Rachakonda VP, Reeves VL, Aljammal J, Wills RC, Trybula JS, DeLany JP, Kienesberger PC, Kershaw EE.

Obesity (Silver Spring). 2015 May;23(5):965-72. doi: 10.1002/oby.20960. Epub 2015 Apr 10.


AMPK-dependent inhibitory phosphorylation of ACC is not essential for maintaining myocardial fatty acid oxidation.

Zordoky BN, Nagendran J, Pulinilkunnil T, Kienesberger PC, Masson G, Waller TJ, Kemp BE, Steinberg GR, Dyck JR.

Circ Res. 2014 Aug 15;115(5):518-24. doi: 10.1161/CIRCRESAHA.115.304538. Epub 2014 Jul 7.


The role of ubiquitin ligases in cardiac disease.

Willis MS, Bevilacqua A, Pulinilkunnil T, Kienesberger P, Tannu M, Patterson C.

J Mol Cell Cardiol. 2014 Jun;71:43-53. doi: 10.1016/j.yjmcc.2013.11.008. Epub 2013 Nov 19. Review.


Hypoxic regulation of hand1 controls the fetal-neonatal switch in cardiac metabolism.

Breckenridge RA, Piotrowska I, Ng KE, Ragan TJ, West JA, Kotecha S, Towers N, Bennett M, Kienesberger PC, Smolenski RT, Siddall HK, Offer JL, Mocanu MM, Yelon DM, Dyck JR, Griffin JL, Abramov AY, Gould AP, Mohun TJ.

PLoS Biol. 2013 Sep;11(9):e1001666. doi: 10.1371/journal.pbio.1001666. Epub 2013 Sep 24. Erratum in: PLoS Biol. 2013 Dec;11(12). doi:10.1371/annotation/a9a7f37a-3fa7-4f7f-8310-1339bf5a666e.


Cardiomyocyte-specific ablation of CD36 improves post-ischemic functional recovery.

Nagendran J, Pulinilkunnil T, Kienesberger PC, Sung MM, Fung D, Febbraio M, Dyck JR.

J Mol Cell Cardiol. 2013 Oct;63:180-8. doi: 10.1016/j.yjmcc.2013.07.020. Epub 2013 Aug 12.


Skeletal muscle triacylglycerol hydrolysis does not influence metabolic complications of obesity.

Sitnick MT, Basantani MK, Cai L, Schoiswohl G, Yazbeck CF, Distefano G, Ritov V, DeLany JP, Schreiber R, Stolz DB, Gardner NP, Kienesberger PC, Pulinilkunnil T, Zechner R, Goodpaster BH, Coen P, Kershaw EE.

Diabetes. 2013 Oct;62(10):3350-61. doi: 10.2337/db13-0500. Epub 2013 Jul 8.

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